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| 1 | Prevalence of occult hepatitis B virus infection in haemodialysis patients from central Greece显示文摘AIM:To assess the hepatitis B virus(HBV)-DNA and the prevalence of occult HBV infection in end-stage renal failure(ESRF)patients from Central Greece. METHODS:Sera from 366 ESRF patients attending five out of six dialysis units from Central Greece were investigated for HBV-DNA by real-time polymerase chain reaction.Only serum samples with repeatedly detectable HBV-DNA were considered positive.IgG antibodies to hepatitis C virus(anti-HCV)were tested by a third generation enzyme linked immunosorbent assay(ELISA),while IgG antibodies to hepatitis E virus (anti-HEV)were tested by two commercially available ELISAs.RESULTS:HBV-DNA was detected in 15/366 patient (4.1%)and HBsAg in 20/366(5.5%).The prevalenc of occult HBV infection was 0.9%(3/346 HBsAg negative patients).Occult HBV was not associate with a specific marker of HBV infection or anti-HCV o anti-HEV reactivity.There was no significant differenc in HBV-DNA titres,demographic and biochemica features,between patients with occult HBV infectio and those with HBsAg-positive chronic HBV infection. CONCLUSION:In central Greece,4%of ESRF patient had detectable HBV-DNA,though in this setting,th prevalence of occult HBV seems to be very low(0.9%). | Paraskevi Mina Sarah P Georgiadou Christos Rizos George N Dalekos Eirini I Rigopoulou | 2010 | World Journal of Gastroenterology2010，16，2： | 8 |
| 2 | Community-level physiological profiles of bacteria and fungi: plate type and incubation temperature influences on contrasting soils显示文摘 | Aimée T Classen Sarah I Boyle Kristin E Haskins Steven T Overby Stephen C Hart | | FEMS Microbiology Ecology0，，： | 2 |
| 3 | Mental health in the post-COVID-19 era:challenges and the way forward显示文摘The COVID-19 pandemic has posed a serious threat to global mental health.Multiple lines of evidence suggest that there is a varying yet considerable increase in mental health issues among the general population and vulnerable groups.12 The aftermath is obscure and speculative from a social,economic,individual and public mental health perspective.Recently published studies support the existence of an emotional epidemic curve,describing a high probability of an increase in the burden of mental health issues in the post-pandemic era.34 Furthermore,previous major public health emergencies showed that more than half of the population devel-oped mental health problems and required mental health intervention.45 There is,therefore,an urgent need to reorganise existing mental health services to address the current unmet needs for mental health and to prepare for future challenges in the postpandemic era in terms of prevention and management. | Ramyadarshni Vadivel Sheikh Shoib Sarah El Halabi Samer El Hayek LamiaàEssam Drita Gashi Bytyçi Ruta Karaliuniene Andre Luiz Schuh Teixeira Sachin Nagendrappa Rodrigo Ramalho Ramdas Ransing Victor Pereira-Sanchez Chonnakarn Jatchavala Frances Nkechi Adiukwu Ganesh Kudva Kundadak | 2021 | General Psychiatry2021，34，1： | 2 |
| 4 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 5 | The mitochondrial proteome and human disease显示文摘 | i Sarah EC Vamsi KM | 2010 | Annu Rev Genomics Hum Genet2010，11，： | 1 |
| 6 | Thiorphon-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluid显示文摘 | Amamda J Newell Lucia I Sue Sarah Scott | 2003 | Neurosci Lett2003，350，3： | 1 |
| 7 | Development of a fluorescence polarization-based diagnostic assay for equine infectious anemia virus显示文摘 | Sarah B T Dazi R I Vandana K | 2000 | Journal of clinical microbiology2000，38，5： | 1 |
| 8 | Design of cylcohexane oxidation process using multiple neural networks显示文摘 | SARAH S Y L ALICE E S BADIE I MORSI | 2001 | J of Manufacturing Systems2001，1，： | 1 |
| 9 | A novel assay for detect- ing canine parvovirus using a quartz crystal microbalance biosen- sor 显示文摘 | Yong K K Seong I L Sarah C | 2015 | J Virol Methods2015，219，： | 1 |
| 10 | The effect of rock fragment size and position on topsoil moisture on arid and semi-arid hillslopes显示文摘 | Katra I Lavee H Sarah P | 2008 | Catena2008，72，1： | 1 |
| 11 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 12 | Preactivated thiomers as mucoad hesive polymers for drug delivery 显示文摘 | JAVED I GUL S SARAH D | 2012 | Biomaterials2012，33，5： | 1 |
| 13 | The pathology of transfusion-related acute lung injury显示文摘 | Sarah MD Kim MB Edgar I M | 1999 | Am J Clin Pathology1999，112，2： | 1 |
| 14 | Biomarkers for Huntington’s disease: an update显示文摘 | Rachael I Scahill Ed J Wild Sarah J Tabrizi | 2012 | Expert Opinion on Medical Diagnostics2012，，5： | 1 |
| 15 | Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to tong-term potentiation by low intracellular calcium buffering显示文摘 | Sarah C Harney I Michael Y | 2006 | J Neurosci2006，26，4： | 1 |
| 16 | DHA Exacerbates Experimentally Induced Colitis in SMAD3-/- Mice显示文摘 | HILLARY L W SARAH I M JONATHAN C | 2010 | FASEB Journal2010，24，： | 1 |
| 17 | Investigation of pre-reaclion and cure temperature onmuUiscale (iispersif)n in POSS-epoxy nanocomposites显示文摘 | Yrank Katherine I』 Exley Sarah E Thornell Travis L etal | | Polymer^O^0，53，21： | 1 |
| 18 | So what's new in the field of plant cold acclimation显示文摘 | Michael F Thomashow Sarah I | 2001 | Plant Physiol2001，125，： | 1 |
| 19 | The effect of rock frag- ment size and position on topsoil moisture on arid and semi-arid hillslopes显示文摘 | Katra I Lavee H Sarah P | 2008 | Catena2008，72，： | 1 |
| 20 | Hypertension is a potential risk factor for vascular dementia : systematic review 显示文摘 | Sally I S Dag A Sarah D H | 2011 | Int J Geriatr Psychiatry2011，26，7： | 1 |
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