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| 1 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 2 | Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage显示文摘证据正在增加精子 DNA 的正直可能也与培植失败和周期性的流产(RM ) 有关。调查这,在有在 vitro 授精,与 RM 诊断的 16 个女人和七位最近的父亲(控制) 列在后面的周期性的培植失败(RIF ) 的 35 个女人的搭挡的精子 DNA 破碎被检验。精子由测试和终端 deoxynucleotidyl transferase dUTP 刻痕结束标记的精子染色质分散(SCD )(TUNEL ) 是检验密度前和密度以后的 centrifugation 试金。在在三之间的搭挡或精子集中,活动性或形态学组织的任何一个的年龄没有重要差别。而且,在 DNA 破碎由也测量了的精子没有明显的差别测试。不管多么虽然平均在所有的精子 DNA 破碎组织当由 SCD 测试测量了时,在准备精子是统计上更低的,这没从 TUNEL 试金与结果被看见。这些结果不支持精子 DNA 破碎是 RIF 或 RM 的一个重要原因的假设,否则测试的那精子 DNA 正直在如此的病人有价值。它也在从精子 DNA 破碎测试解释数据加亮测试方法论和精子准备方法之间的重要差别。 | Carol Coughlan Helen Clarke Rachel Cutting Jane Saxton Sarah Waite William Ledger Tinchiu Li Allan A Pacey | 2015 | Asian Journal of Andrology2015，17，4： | 17 |
| 3 | Uplift, climate and biotic changes at the Eocene-Oligocene transition in south-eastern Tibet显示文摘The uplift history of south-eastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas.Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernization of the highly diverse,but threatened,Asian biota.Here,with new radiometric dating and newly collected plant-fossil archives,we quantify the surface height of part of the south-eastern margin of Tibet in the latest Eocene(~34 Ma)to be^3 km and rising,possibly attaining its present elevation(3.9 km)in the early Oligocene.We also find that the Eocene–Oligocene transition in south-eastern Tibet witnessed leaf-size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate,likely reflective of both uplift and secular climate change,and that,by the latest Eocene,floral modernization on Tibet had already taken place,implying modernization was deeply rooted in the Palaeogene. | Tao Su Robert A. Spicer Shi-Hu Li He Xu Jian Huang Sarah Sherlock Yong-Jiang Huang Shu-Feng Li Li Wang Lin-Bo Jia Wei-Yu-Dong Deng Jia Liu Cheng-Long Deng Shi-Tao Zhang Paul J. Valdes Zhe-Kun Zhou | 2019 | National Science Review2019，6，3： | 16 |
| 4 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 5 | Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared显示文摘Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity.Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs.Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor growth.This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser excitation.Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species. | Zhuang Liu Scott Tabakman Sarah Sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai | 2010 | Nano Research2010，3，3： | 11 |
| 6 | Arabidopsis Extra Large G-Protein 2 (XLG2) Interacts with the Gβ Subunit of Heterotrimeric G Protein and Functions in Disease Resistance显示文摘Heterotrimeric GTP 有约束力的蛋白质,由 G, G,和 G 子单元组成,在细胞外的信号由房间表面受体察觉了进细胞内部的生理的回答的 transducing 起重要作用。除了单个原型的 G 蛋白质(GPA1 ) , Arabidopsis 有三唯一的象 G 一样蛋白质,作为 XLG1, XLG2,和 XLG3 知道,那被发现了在原子核局部性,尽管他们行动的功能和模式仍然保持大部分未知。通过 transcriptomic 分析,我们发现 XLG2 和 XLG3 被感染很快与细菌的病原体 Pseudomonas syringae 导致,而 XLG1 抄本水平没被病原体感染影响。一幅反向的基因屏幕表明 xlg2 loss-of-function 变化原因提高了危险性到 P。syringae。介绍的 Transcriptome 表明 xlg2 变化影响防卫相关的基因的一个小集合的被触发病原体的正式就职。然而, xlg1 和 xlg3 异种没在抵抗从野类型的植物显示出差别到 P。syringae。另外, xlg2 xlg3 两倍异种和 xlg1 xlg2 xlg3 三元组异种不与在疾病抵抗显型的 xlg2 单身者异种显著地不同,建议如果有的话,在防卫的 XLG1 和 XLG3 的角色不比为 XLG2 重要。XLG2 的组成的 overexpression 从多重防卫相关的基因导致反常抄本的累积。通过 co-immunoprecipitation 试金, XLG2 被发现与 AGB1 交往,在 Arabidopsis 的唯一的 G 子单元,它以前被发现了是在到 necrotrophic 的抵抗的一个积极管理者真菌的病原体。然而,没有重要差别在三 xlg 单身者异种之间被发现, xlg2 xlg3 在到 necrotrophic 的抵抗的两倍异种, xlg 三元组异种,和野类型的植物真菌的病原体 Botrytis cinerea 或 Alternaria brassicicola。这些结果建议 XLG2 和 AGB1 是与原型的 heterotrimeric G 蛋白质不同的 G 蛋白质建筑群的部件并且可以在 modulating 防卫回答有不同功能。 | Huifen Zhu Guo-Jing Li Lei Ding Xiangqin Cui Howard Berg Sarah M. Assmann Yiji Xia | 2009 | Molecular Plant2009，2，3： | 8 |
| 7 | Spatiotemporal variation of drought characteristics in the Huang- Huai-Hai Plain, China under the climate change scenario显示文摘Understanding the potential drought characteristics under climate change is essential to reduce vulnerability and establish adaptation strategies,especially in the Huang-Huai-Hai Plain(3 H Plain),which is a major grain production area in China. In this paper,we investigated the variations in drought characteristics(drought event frequency,duration,severity,and intensity) for the past 50 years(1961–2010) and under future scenarios(2010–2099),based on the observed meteorological data and the Representative Concentration Pathway(RCP) 8.5 scenario,respectively. First,we compared the applicability of three climatic drought indices:the standardized precipitation index(SPI),the standardized precipitation evapotranspiration index based on the Penman-Monteith equation(SPEI-PM) and the same index based on the Thornthwaite equation(SPEI-TH) to correlate the recorded agricultural drought areas. Then,we analyzed the drought characteristics using ‘run theory' for both historical and the future RCP 8.5 scenario based on the best performing index. Correlation analyses between drought indices and agricultural drought areas showed that SPEI-PM performed better than SPI and SPEI-TH in the 3 H Plain. Based on the results of SPEI-PM,drought risks including duration,severity and intensity during 1961–2010 showed an decreasing trend. However,under the RCP 8.5 scenario,drought is expected to rise in frequency,duration,severity,and intensity from 2010–2099,although drought components during the 2010–2039 are predicted to be milder compared with historical conditions. This study highlights that the estimations for atmospheric evaporative demand would create differences in the prediction of long-term drought trends by different drought indices. The results of this study can help inform researchers and local policy makers to establish drought management strategies. | LI Xiang-xiang JU Hui Sarah Garré YAN Chang-rong William D.Batchelor LIU Qin | 2017 | Journal of Integrative Agriculture2017，16，10： | 6 |
| 8 | Data-Driven Microstructure and Microhardness Design in Additive Manufacturing Using a Self-Organizing Map显示文摘To design microstructure and microhardness in the additive manufacturing(AM)of nickel(Ni)-based superalloys,the present work develops a novel data-driven approach that combines physics-based models,experimental measurements,and a data-mining method.The simulation is based on a computational thermal-fluid dynamics(CtFD)model,which can obtain thermal behavior,solidification parameters such as cooling rate,and the dilution of solidified clad.Based on the computed thermal information,dendrite arm spacing and microhardness are estimated using well-tested mechanistic models.Experimental microstructure and microhardness are determined and compared with the simulated values for validation.To visualize process-structure-properties(PSPs)linkages,the simulation and experimental datasets are input to a data-mining model-a self-organizing map(SOM).The design windows of the process parameters under multiple objectives can be obtained from the visualized maps.The proposed approaches can be utilized in AM and other data-intensive processes.Data-driven linkages between process,structure,and properties have the potential to benefit online process monitoring control in order to derive an ideal microstructure and mechanical properties. | Zhengtao Gan Hengyang Li Sarah J.Wolff Jennifer L.Bennett Gregory Hyatt Gregory J.Wagner Jian Cao Wing Kam Liu | 2019 | Engineering2019，5，4： | 4 |
| 9 | Single-event-effect propagation investigation on nanoscale system on chip by applying heavy-ion microbeam and event tree analysis显示文摘The propagation of single-event effects(SEEs)on a Xilinx Zynq-7000 system on chip(SoC)was inves-tigated using heavy-ion microbeam radiation.The irradia-tion results reveal several functional blocks’sensitivity locations and cross sections,for instance,the arithmetic logic unit,register,D-cache,and peripheral,while irradi-ating the on-chip memory(OCM)region.Moreover,event tree analysis was executed based on the obtained microbeam irradiation results.This study quantitatively assesses the probabilities of SEE propagation from the OCM to other blocks in the SoC. | Wei-Tao Yang Xue-Cheng Du Yong-Hong Li Chao-Hui He Gang Guo Shu-Ting Shi Li Cai Sarah Azimi Corrado De Sio Luca Sterpone | 2021 | Nuclear Science and Techniques2021，32，10： | 3 |
| 10 | MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors显示文摘 | Liu Xi Sempere Lorenzo F Ouyang Haoxu Memoli Vincent A Andrew Angeline S Luo Yue Demidenko Eugene Korc Murray Shi Wei Preis Meir Dragnev Konstantin H Li Hua DiRenzo James Bak Mads Freemantle Sarah J Kauppinen Sakari Dmitrovsky Ethan | 2010 | Journal of Clinical Investigation2010，，4： | 3 |
| 11 | Internal control and management guidance显示文摘 | Mei Feng Chan Li Sarah McVay | 2009 | Journal of Accounting and Economics2009，，2： | 3 |
| 12 | DNNGP, a deep neural network-based method for genomic prediction using multi-omics data in plants显示文摘Genomic prediction is an effective way to accelerate the rate of agronomic trait improvement in plants.Traditional methods typically use linear regression models with clear assumptions;such methods are unable to capture the complex relationships between genotypes and phenotypes.Non-linear models(e.g.,deep neural networks)have been proposed as a superior alternative to linear models because they can capture complex non-additive effects.Here we introduce a deep learning(DL)method,deep neural network genomic prediction(DNNGP),for integration of multi-omics data in plants.We trained DNNGP on four datasets and compared its performance with methods built with five classic models:genomic best linear unbiased prediction(GBLUP);two methods based on a machine learning(ML)framework,light gradient boosting machine(LightGBM)and support vector regression(SVR);and two methods based on a DL framework,deep learning genomic selection(DeepGS)and deep learning genome-wide association study(DLGWAS).DNNGP is novel in five ways.First,it can be applied to a variety of omics data to predict phenotypes.Second,the multilayered hierarchical structure of DNNGP dynamically learns features from raw data,avoiding overfitting and improving the convergence rate using a batch normalization layer and early stopping and rectified linear activation(rectified linear unit)functions.Third,when small datasets were used,DNNGP produced results that are competitive with results from the other five methods,showing greater prediction accuracy than the other methods when large-scale breeding data were used.Fourth,the computation time required by DNNGP was comparable with that of commonly used methods,up to 10 times faster than DeepGS.Fifth,hyperparameters can easily be batch tuned on a local machine.Compared with GBLUP,LightGBM,SVR,DeepGS and DLGWAS,DNNGP is superior to these existing widely used genomic selection(GS)methods.Moreover,DNNGP can generate robust assessments from diverse datasets,including omics data,and quickly incorporate complex and large datasets into usable models,making it a promising and practical approach for straightforward integration into existing GS platforms. | Kelin Wang Muhammad Ali Abid Awais Rasheed Jose Crossa Sarah Hearne Huihui Li | 2023 | Molecular Plant2023，16，1： | 3 |
| 13 | 25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor显示文摘Dear Editor,As of July,2020,the ongoing pandemic of coronavirus diseases 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2,previously 2019-nCoV)has caused more than 10.3 million human infections,with more than 506,000 deaths worldwide according to the World Health Organization.The clinical manifestations of COVID-19 vary from no asymptomatic infection,mild“flu-like”symptoms,to lethal acute respiratory distress syndrome.The case mortality and fatality rates in people infected with SARS-CoV-2 increase steeply with age,and fatal outcomes are almost exclusively seen in people older than 50 years.1 Although the Food and Drug Administration has authorized emergency use of remdesivir for COVID-19 treatment in the US,the need for safe and effective antiviral drugs against SARS-CoV-2 remains urgent and unmet. | Shulong Zu Yong-Qiang Deng Chao Zhou Jie Li Lili Li Qi Chen Xiao-Feng Li Hui Zhao Sarah Gold Jun He Xiang Li Changqing Zhang Heng Yang Genhong Cheng Cheng-Feng Qin | 2020 | Cell Research2020，30，11： | 3 |
| 14 | HIV care continuum among newly diagnosed student and non-student youths between 2012 and 2016 in Hangzhou, China显示文摘Background: Youths are disproportionally affected by the human immunodeficiency virus (HIV) infection. We aimed to assess antiretroviral therapy (ART) initiation and viral suppression rates among student and non-student youths in Hangzhou, China. Methods: Data were taken from the Chinese HIV/acquired immune deficiency syndrome Comprehensive Response Information Management System. Youths aged 15 to 24 years who were newly diagnosed with HIV between 2012 and 2016 and were living in Hangzhou were included in the study. Comparisons between student and non-student youths were made for ART initiation within 30 days, 90 days, and 12 months of HIV diagnosis, and the viral suppression rate at 12 months of HIV diagnosis and at 12 months of ART initiation. Results: A total of 707 cases met inclusion criteria, 29.6% of which were students and 70.4% were non-student youths. The student group had a higher proportion of ART initiation compared with the non-student group within 30 days of diagnosis (45.5% vs. 37.0%, P = 0.044), and a slightly higher but not statistically significant proportion at 90 days (67.0% vs. 62.7%), and 12 months (83.7% vs. 78.5%) of HIV diagnosis. ART initiation within 30 days improved from <15% in 2012 to over 65% in 2016 in both groups, and ART initiation within 90 days improved from <30% in 2012 to >90% in 2016. A smaller proportion of students experienced viral suppression compared with the non-student group (9.6% vs. 17.1%, P = 0.011) at 12 months after HIV diagnosis, but the suppression rate was similar at 12 months of ART initiation (69.9% vs. 71.1%, P = 0.743). Conclusions: ART initiation in both student and non-student youths has significantly improved between 2012 and 2016. However, the viral suppression rate remained unacceptably low at 12 months of HIV diagnosis in both student and non-student groups. Specific intervention strategies must be taken to address this challenge. | Yan Luo Hong Wu Xing-Liang Zhang Xi-Ting Li Sarah Robbins Scott Jun-Fang Chen Zun-You Wu | 2019 | Chinese Medical Journal2019，，12： | 2 |
| 15 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 16 | Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis显示文摘Background:Liver regeneration following partial hepatectomy(PHx)is a complicated process involving multiple organs and several types of signaling networks.The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story.PHx is characterized by rapid but transient bile acid overload in the liver,which constitutes the first wave of proliferative signaling in the remnant hepatocytes.Bile acids trigger hepatocyte proliferation through activation of several nuclear receptors.Following biliary passage into the intestines,enterocytes reabsorb the bile acids,which results in the activation of farnesoid X receptor(FXR),the consequent excretion of fibroblast growth factor(FGF)19/FGF15,and its release into the enterohepatic circulation.FGF19/FGF15 subsequently binds to its cognate receptor,fibroblast growth factor receptor 4(FGFR4)complexed withβ-klotho,on the hepatocyte membrane,which initiates the second wave of proliferative signaling.Because some bile acids are toxic,the remnant hepatocytes must resolve the potentially detrimental state of bile acid excess.Therefore,the hepatocytes orchestrate a bile acid detoxification and elimination response as a protective mechanism in concurrence with the proliferative signaling.The response in part results in the excretion of(biotransformed)bile acids into the canalicular system,causing the bile acids to end up in the intestines.Relevance for patients:Recently,FXR agonists have been shown to promote regeneration via the gut-liver axis.This type of pharmacological intervention may prove beneficial for patients with hepatobiliary tumors undergoing PHx.In light of these developments,the review provides an in-depth account of the pathways that underlie post-PHx liver regeneration in the context of bile acid homeostasis in the liver and the gut-liver signaling axis. | Lianne de Haan Sarah Jvan der Lely Anne-Loes K.Warps Quincy Hofsink Pim B.Olthof Mark J.de Keijzer Daniel A.Lionarons Lionel Mendes-Dias Bote G.Bruinsma Korkut Uygun Hartmut Jaeschke Geoffrey C.Farrell Narci Teoh Rowan Fvan Golen Tiangang Li Michal Heger | 2018 | Journal of Clinical & Translational Research2018，4，1： | 2 |
| 17 | Ranibizumab for Macular Edema following Central Retinal Vein Occlusion显示文摘 | David M. Brown Peter A. Campochiaro Rishi P. Singh Zhengrong Li Sarah Gray Namrata Saroj Amy Chen Rundle Roman G. Rubio Wendy Yee Murahashi | 2010 | Ophthalmology2010，，6： | 2 |
| 18 | Liquid Transport in Rectangular Microchannels by Electroosmotic Pumping显示文摘 | Arulanandam Sarah LI Dong-qing | 2000 | Colloids and Surfaces A2000，161，： | 1 |
| 19 | Arylsulfatase activity of soil microbial biomass along a Mediterranean-arid transect 显示文摘 | Li X Z Sarah P | 2003 | Soil Biology and Biochemistry2003，35，7： | 1 |
| 20 | Role of the vagus nerve on the development of postoperative ileus显示文摘 | Zhirong Gao Mario H. Müller Martina Karpitschka Sarah Mittler Michael S. Kasparek Bernhard Renz Andrej Sibaev J?rg Glatzle Yongyu Li Martin E. Kreis | 2010 | Langenbeck’s Archives of Surgery2010，，4： | 1 |
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