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| 1 | Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis显示文摘Necroptosis 和 pyroptosis 是有血浆膜破裂的一个普通特征的规划房间死亡的二种形式。这里,我们与 necroptosis 比较学习了 pyroptosis 的形态学和机制。与 necroptosis 不同, pyroptosis 经历膜 blebbing 并且生产 apoptotic 在血浆膜以前的像身体的房间伸出(称为的 pyroptotic 身体) 破裂。在 necroptosis 的破裂是像爆炸的,而在 pyroptosis 它导致房间变平。necroptosis 的实行被混合的系 kinase 调停,这被知道像域(MLKL ) 在血浆膜的 oligomers,而 gasdermin-D (GSDMD ) 调停在它由 caspase-1 或 caspase-11 的劈开以后的 pyroptosis。我们显示出那 N 终端碎片 caspase 劈开产生的 GSDMD (GSDMD-N ) 也形成 oligomer 并且移居到血浆膜杀死房间。MLKL 和 GSDMD-N 是脂性的,两蛋白质的 N 终端序列为他们的 oligomerization 和血浆膜 translocation 是重要的。不同于在血浆膜上形成隧道的 MLKL,那导致渗透地胀大的选择离子的流入冲破的房间, GSDMD-N 形成非选择的毛孔并且不依靠增加的 osmolarity 破坏房间。我们的学习表明 GSDMD 的形成毛孔的活动和 MLKL 的形成隧道的活动在 pyroptosis 和 necroptosis 决定血浆膜破裂的不同方法。 | Xin Chen Wan-ting He Lichen Hu Jingxian Li Yuan Fang Xin Wang Xiaozheng Xu Zhuo Wang Kai Huang Jiahuai Han | 2016 | Cell Research2016，26，9： | 110 |
| 2 | Restoring urbanization process in China in the 1990s by using non-radiance-calibrated DMSP/OLS nighttime light imagery and statistical data显示文摘Since current administrative unit-based urban land area statistical data in China lack enough spatial information, the urbanization process re- search at large scale cannot be effectively supported. Based on the current administrative unit-based urban land area statistical data in China, a new approach to quickly and cheaply derive urban land information from the non-radiance-calibrated Defense Meteoro- logical Satellite Program/ Operational Linescan Sys- tem (DMSP/OLS) nighttime light imagery is pre- sented in this paper. With the new approach, the ur- ban pattern information in China in 1992, 1996 and 1998 was derived with the urbanization processes in China in the 1990s restored by using the non-ra- diance-calibrated DMSP/OLS nighttime imagery. The accuracy assessment based on the statistical data showed that the relative error between the derived total urban land area and the statistical data at na- tional scale was less than 2% in 1992, and less than 1% in 1996 and 1998, and the maximum relative er- ror at province scale do not exceed 10% with most of the provinces less than 3%. In addition, the urban patterns derived from the high-resolution Landsat TM imagery were compared with those from the DMSP/ OLS data. The results showed that the urban pattern characteristics derived from DMSP/OLS were basi-cally coincident with those from TM imagery with the total accuracy of about 80%. Thus it can be seen that our restored urbanization process in China in the 1990s by using the non-radiance DMSP/OLS night- time imagery can be accepted and can represent the actual urban development in China at that time on the whole. | HE Chunyang SHI Peijun LI dinggang CHEN din PAN Yaozhong LI ding ZHUO Li Ichinose Toshiaki | 2006 | Chinese Science Bulletin2006，51，13： | 55 |
| 3 | he Spectrum of Biopsy-Proven Glomerular Disease in China: A Systematic Review显示文摘 | Yue Yang Zheng Zhang Li Zhuo Da-Peng Chen Wen-Ge Li | 2018 | Chinese Medical Journal2018，，6： | 53 |
| 4 | TiO_(2) Nanocrystals Grown on Graphene as Advanced Photocatalytic Hybrid Materials显示文摘A graphene/TiO_(2) nanocrystals hybrid has been successfully prepared by directly growing TiO_(2) nanocrystals on graphene oxide(GO)sheets.The direct growth of the nanocrystals on GO sheets was achieved by a two-step method,in which TiO_(2) was first coated on GO sheets by hydrolysis and crystallized into anatase nanocrystals by hydrothermal treatment in the second step.Slow hydrolysis induced by the use of EtOH/H2O mixed solvent and addition of H2SO4 facilitates the selective growth of TiO_(2) on GO and suppresses growth of free TiO_(2) in solution.The method offers easy access to the GO/TiO_(2) nanocrystals hybrid with a uniform coating and strong interactions between TiO_(2) and the underlying GO sheets.The strong coupling gives advanced hybrid materials with various applications including photocatalysis.The prepared graphene/TiO_(2) nanocrystals hybrid has superior photocatalytic activity to other TiO_(2) materials in the degradation of rhodamine B,showing an impressive three-fold photocatalytic enhancement over P25.It is expected that the hybrid material could also be promising for various other applications including lithium ion batteries,where strong electrical coupling to TiO_(2) nanoparticles is essential. | Yongye Liang Hailiang Wang Hernan Sanchez Casalongue Zhuo Chen Hongjie Dai | 2010 | Nano Research2010，3，10： | 57 |
| 5 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 6 | Advanced Asymmetrical Supercapacitors Based on Graphene Hybrid Materials显示文摘Supercapacitors 在水的答案操作是有能力的高骑车稳定性并且快收费并且排出的低费用精力存储设备,但是通常受不了低精力密度。这里,我们种 Ni (哦) 高质量的 graphene 表上的 2 nanoplates 和 RuO2 nanoparticles 以便最大化这些材料的特定的电容。我们然后在 Ni 上面配对(哦) 有一个 RuO2/graphene 电极到的 2/graphene 电极负担得起高效有在 1.5 V 的电压在水的答案操作的高精力和功率密度的不均匀的 supercapacitor。不均匀的 supercapacitor 基于 RuO2 碳或 Ni 比对称的 RuO2-RuO2 supercapacitors 或不均匀的 supercapacitors 展出显著地更高的精力密度(哦)2 碳电极对。48 W 甠瑬慲散瑮楲畦慧楴湯的高精力密度? | Hailiang Wang Yongye Liang Tissaphern Mirfakhrai Zhuo Chen Hernan Sanchez Casalongue Hongjie Dai | 2011 | Nano Research2011，4，8： | 37 |
| 7 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 8 | 配戴角膜塑形镜和框架眼镜对近视儿童周边屈光度影响的随机对照临床试验显示文摘背景临床实践发现角膜塑形镜具有延缓近视及眼轴长度进展的效果,但对于角膜塑形镜配戴的相关作用机制,特别是角膜塑型术对视网膜中心和周边的离焦作用机制尚不完全清楚。目的观察低中度近视儿童配戴角膜塑形镜和框架眼镜6个月后周边屈光度以及相对周边屈光度(RPR)的变化。方法采用随机对照临床试验方法,于2014年6月至2015年1月在北京同仁眼科中心招募屈光度为-0.50~-6.00 D的低中度近视儿童100例,平均年龄(11.0±1.9)岁,均纳入右眼进行研究。受试者按入组顺序编号后由SAS统计软件PROC PLAN过程语句随机均分为角膜塑形镜组和框架眼镜组,每组50例50眼,戴镜时间均为6个月。采用开放视野红外自动验光仪分别测量戴镜前后中央0°、颞侧15°和30°、鼻侧15°和30°径线的屈光度,观察并比较各组受试眼戴镜前后周边屈光度和RPR(周边屈光度与中央屈光度差值)变化趋势。结果角膜塑形镜组和框架眼镜组受试者戴镜前屈光度分别为(-3.35±1.31)D和(-3.01±1.15)D,差异无统计学意义(P=0.201)。角膜塑形镜组受试眼戴镜前鼻侧30°、鼻侧15°、中央0°、颞侧15°和颞侧30°径线周边屈光度分别为(-2.28±1.60)、(-3.28±1.41)、(-3.40±1.23)、(-3.38±1.12)和(-2.09±1.29)D,受试眼除颞侧30°外戴镜后6个月近视度数均下降,戴镜前后鼻侧30°、鼻侧15°、中央0°、颞侧15°屈光度变化值分别为(0.29±1.67)、(0.85±1.66)、(0.92±1.76)和(0.66±1.66)D,其中鼻侧15°、中央0°、颞侧15°与戴镜前相比差异均有统计学意义(均P〈0.05)。框架眼镜组受试者戴镜前鼻侧30°、鼻侧15°、颞侧15°和颞侧30°径线周边屈光度分别为(-1.88±1.30)、(-2.66±1.18)、(-2.89±1.27)和(-1.94±1.31)D,戴镜后6个月上述各径线近视度数均增加,戴镜前后变化值分别为(-0.25±0.80)、(-0.43±0.67)、(-0.32±0.64)和(-0.22±0.75)D,与戴镜前比较差异均有统计学意义(均P〈0.05)。角膜塑形镜组受试者戴镜前各径线RPR均为远视性离焦状态,戴镜后6个月颞侧15°和颞侧30°RPR变为近视性离焦状态。框架眼镜组受试者戴镜前各径线RPR均为远视性离焦状态,戴镜后各径线RPR均呈远视性离焦加深状态。结论长期配戴角膜塑形镜能够使近视儿童的周边屈光度发生远视性漂移,视网膜周边呈现相对近视性离焦,而长期配戴框架眼镜则使周边屈光度发生近视漂移,视网膜周边远视性离焦加深。角膜塑形镜配戴可能通过改变周边屈光度而达到减缓近视进展的目的。 | 魏士飞 李仕明 孙芸芸 康梦田 孟博 冉安然 严然 白雅雯 Zhuo Chen 王宁利 | 2017 | 中华实验眼科杂志2017，35，10： | 34 |
| 9 | Oral health status in Sichuan Province: findings from the oral health survey of Sichuan, 2015–2016显示文摘To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using the latest Oral Health Survey Basic Methods recommended by the World Health Organization. A multistage stratified random cluster-sampling method was used to enroll participants from the following three groups: children aged 3–5 years,adolescents aged 12 years, and people aged 65–74 years. In these three groups, the mean numbers of teeth that were affected by caries were 3.28, 0.86 and 5.13, respectively, resulting in a prevalence of 63.47%, 37.20% and 83.20%, respectively.Relative to the high rate of decayed teeth, the prevalence of fillings was very low in all age groups(0.97%, 7.24% and 5.43%,respectively). In the 12-year-old adolescent group, only 3.61% had good pit and fissure sealing. In addition, the rate of dental fluorosis was 24.80%, and the Community Fluorosis Index value was 0.39. In the elder group, the community periodontal index was2.92. The prevalence in the elderly of having lost at least one tooth was 75.54%. Additionally, 4.44% of these participants were edentulous. The incidence of dental prosthesis was 51.75%, the proportion with a removable partial denture, a fixed denture, full dentures, dental implants and an informal fixed bridge was 21.59%, 11.45%, 4.64%, 0 and 16.67%, respectively. In this study,8.2% of the elderly participants were affected by different types of oral mucosal lesions. Among such lesions, recurrent aphthous ulcers were most prevalent(2.69%) and oral lichen planuses were second(1.6%). The conclusion presented in this survey is that oral diseases, especially dental caries and periodontal disease, are frequent and common in Sichuan province, China. Moreover, the treatment rate is very low, and primary prevention and treatment options are therefore urgently needed in this population. | Wei Yin Ying-Ming Yang Hong Chen Xue Li Zhuo Wang Li Cheng Qiu-Dan Yin Hong-Zhi Fang Wei Fei Fang-Lin Mi Min-Hai Nie Tao Hu Xue-Dong Zhou | 2017 | International Journal of Oral Science2017，9，1： | 30 |
| 10 | Effect of a cancer vaccine prepared by fusions of hepatocarcinoma cells with dendritic cells显示文摘AIM To prepare a cancer vaccine (H22-DC) expressing high levels of costimulatory molecules based on fusions of hepatocarcinoma cells ( H22 ) with dendritic cells (DC) of mice and to analyze the biological characteristics and induction of specific CTL activity of H22-DC.``METHODS DCs were isolated from murine spleen by metrizamide density gradient centrifugation, purified based on its characteristics of semi-adhesion to culture plates and FcR , and were cultured in the medium containing GM. CSF and IL-4. A large number of DC were harvested. DCs were then fused with H22 cells by PEG and the fusion cells were marked with CDllc MicroBeads. The H22-DC was sorted with Mimi MACS sorter. The techniques of cell culture, immunocytochemistry and light microscopy were also used to test the characteristice of growth and morphology of H22-DC in vitro. As the immunogen, H22-DC was inoculated subcutaneously into the right armpit of BALB/C mice, and their tumorigenicity in vive was observed. MTT was used to test the CTL activity of murine spleen in vitro.``RESULTS DC cells isolated and generated were CD1 lc +cells with irregular shape, and highly expressed CD80,CD86 and CD54 molecules. H22 cells were CDllc cells with sphericel shape and bigger volume, and did not express CD80, CD86 and CD54 molecules. H22-DC was CDllc+ cells with bigger volume, being spherical, flat or irregular in shape, and highly expressed CD80, CD86 and CD54 molecules, too. H22-DC was able to divide and proliferate in vitro, but its activity of proliferation was significantly decreased as compared with H22 cells and its growth curve was flatter than H22 cells. After subcutaneous inoculation over 60 days, 1-12_2-DC showed no tumorigenecity in mice, which was significantly different from control groups (P< 0.01 ) . The spleen CTL activity against H22 cells in mice implanted with fresh H22-DC was significantly higher than control groups (P< 0.0l).``CONCLUSION H22-DC could significantly stimulate the specific CTL activity of murine spleen, which suggests that the fusion cells have already obtained the function of antigen presenting of parental DC and could present H22specific antigen which has not been identified yet, and H22-DC could induce antitumor immune response; although simply mixed H22 cells with DC could stimulate the specific CTL activity which could inhibit the growth of tumor in some degree, it could not prevent the generation of tumor. It shows that the DC vaccine is likely to become a helpful approach in immunotherapy of hepstocarcinoma. | Juan Zhang~1 Jin-Kun Zhang~2 Shao-Hong Zhuo~3 Hai-Bin Chen~2 1 Clinical Laboratory,The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China2 Cancer Pathology Laboratory,Shantou University Medical College,Shantou 515031,Guangdong Province,China3 Department of Gastroenterology,Third Municipal Hospital of Shantou,Shantou 515073,Guangdong Province,China | 2001 | World Journal of Gastroenterology2001，7，5： | 26 |
| 11 | Modified Da-chai-hu Decoction regulates the expression of occludin and NF-κB to alleviate organ injury in severe acute pancreatitis rats显示文摘Modified Da-chai-hu Decoction(MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis(SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present study, rat SAP model was induced by retrograde injection of 3.5% sodium taurocholate into the biliopancreatic duct, MDD(23.35 g/kg body weight, twelve times the clinical dose) were orally given at 2 h before and 10 h after injection. At 12 h after model induction, blood was taken from vena cava for analysis of amylase, diamine oxidase(DAO), pulmonary surfactant protein-A(SP-A), and C-reactive protein(CRP). Histopathological change of pancreas, ileum and lung was assayed by H&E staining, myeloperoxidase(MPO) activity were determinated using colorimetric assay, and the expressions of occludin and nuclear factor-κB(NF-κB) were detected by real-time RT-PCR and western blot, respectively. In addition, the tissue concentrations of tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), and monocyte chemoattractant protein-1(MCP-1) were measured by enzyme-linked immunosorbent assay(ELISA). The results showed that in SAP rats, MDD significantly alleviated histopathological damage, depressed the MPO activity and the concentrations of TNF-α, IL-1β, and MCP-1 of pancreas, ileum and lung, and reduced the serum levels of amylase [(3283.4±585.5) U·L^(-1) vs(5626.4±795.1) U·L^(-1)], DAO[(1100.1±334.3) U·L^(-1) vs(1666.4±525.3) U·L^(-1)] and CRP [(7.6±1.2) μg·mL^(-1) vs(17.8±3.8) μg·mL^(-1)]. However, the serum SP-A concentration [(106.1±16.6) pg·mL^(-1) vs(90.1±14.9) pg·mL^(-1)] was elevated when treated SAP rats with MDD. Furthermore, MDD increased the occludin expression and reduced the NF-κB expression in pancreas, ileum and lung of SAP rats. Our findings suggested that MDD administration was an effective therapeutic approach for SAP treatment. It could up-regulate occludin expression to protect intercellular tight junction and down-regulate NF-κB expression to inhibit inflammatory reaction of pancreas, ileum and lung. | ZHAO Guang ZHUO Yu-Zhen CUI Li-Hua LI Cai-Xia CHEN Sha-Yan LI Dan LIU Jun-Hong LI Di-Hua CUI Nai-Qiang ZHANG Shu-Kun | 2019 | Chinese Journal of Natural Medicines2019，17，5： | 23 |
| 12 | The Chromosome-Level Genome Sequence of the Autotetraploid Alfalfa and Resequencing of Core Germplasms Provide Genomic Resources for Alfalfa Research显示文摘Alfalfa(Medicago sativa)is one of the most important forage crops in the world;however,its molecular genetics and breeding research are hindered due to the lack of a high-quality reference genome.Here,we report a de novo assembled 816-Mb high-quality,chromosome-level haploid genome sequence for‘Zhongmu No.1’alfalfa,a heterozygous autotetraploid.The contig N50 is 3.92 Mb,and 49165 genes are annotated in the genome.The alfalfa genome is estimated to have diverged from M.truncatula approximately 8 million years ago.Genomic population analysis of 162 alfalfa accessions revealed high genetic diversity,weak population structure,and extensive gene flow from wild to cultivated alfalfa.Genome-wide association studies identified many candidate genes associated with important agronomic traits.Furthermore,we showed that MsFTa2,a Flowering Locus T homolog,whose expression is upregulated in salt-resistant germplasms,may be associated with fall dormancy and salt resistance.Taken together,these genomic resources will facilitate alfalfa genetic research and agronomic improvement. | Chen Shen Huilong Du Zhuo Chen Hongwei Lu Fugui Zhu Hong Chen Xiangzhao Meng Qianwen Liu Peng Liu Lihua Zheng Xiuxiu Li Jiangli Dong Chengzhi Liang Tao Wang | 2020 | Molecular Plant2020，13，9： | 21 |
| 13 | Chronology and geochemistry of the volcanic rocks in Woruo Mountain region,Northern Qiangtang depression:Implications to the Late Triassic volcanic-sedimentary events显示文摘A suite of sedimentary-volcaniclastic rocks intercalated with the volcanic rocks unconformably overlies the Triassic Xiaochaka Formation in the Woruo Mountain region, Qiangtang Basin, northern Tibet. The vitric tuff from the base of these strata gives a SHRIMP zircon U-Pb age of 216 ± 4.5 Ma, which represents the age of the Late Triassic volcanic-sedimentary events in the Woruo Mountain region, and is consistent with that of the formation of the volcanic rocks from the Nadi Kangri Formation in the Nadigangri-Shishui River zone. There is a striking similarity in geochemical signatures of the volcanic rocks from the Woruo Mountain region and its adjacent Nadigangri-Shishui River zone, indicating that all the volcanic rocks from the Qiangtang region might have the same magmatic source and similar tectonic setting during the Late Triassic. The proper recognition of the Late Triassic large-scale volcanic eruption and volcanic-sedimentary events has important implications for the interpretation of the Late Triassic biotic extinction, climatic changes and regressive events in the eastern Tethyan domain, as well as the understanding of the initiation and nature, and sedimentary features of the Qiangtang Basin during the Late Triassic-Jurassic. | WANG Jian FU XiuGen CHEN WenXi WANG ZhengJiang TAN FuWen CHEN Ming ZHUO JieWen | 2008 | Science China Earth Sciences2008，51，2： | 21 |
| 14 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 15 | Relation between electricity structure of the crust and deformation of crustal blocks on the northeastern margin of Qinghai-Tibet Plateau显示文摘Study on the electricity structure along a magnetotelluric (MT) sounding profile on the northeastern margin of Qinghai-Tibet Plateau indicates that four crustal blocks can be de-termined from southwest to northeast, namely Bayan Har block (BH), Qin-Qi block (QQ), Hai-yuan block (HY) or the North-South seismotectonic belt and Ordos block (OD). The BH, QQ and OD blocks display a similar electricity structure of the crust. The upper crust represents a high- resistivity layer and the upper part of lower crust represents a low-resistivity layer with the resis-tivity increasing gradually with depth from the lower part of lower crust to the upper mantle. The electricity structure of the crust in these three blocks is similar to that in the complete blocks on the southern and eastern margins of the Qinghai-Tibet Plateau and belongs to normal electricity layering of the crust in slightly deformed or complete intracontinental blocks. The crust in HY block as a boundary zone has been significantly deformed, hence its electricity layering was de-stroyed and the structure was complex and the block became a recent tectonically active and great seismo-active region. The contact belts between the blocks on the northeastern margin of Qinghai-Tibet Plateau exhibit both upthrusting outward and strike-slip movement different from those on the southern and eastern margins of the plateau. The genesis of the low-resistivity layer in the crust is analyzed and the thickness of the lithosphere is estimated in the paper. | ZHAO Guoze TANG Ji ZHAN Yan CHEN Xiaobin ZHUO Xianjun WANG Jijun XUAN Fei DENG Qianhui ZHAO Junmeng | 2005 | Science China Earth Sciences2005，48，10： | 20 |
| 16 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 17 | Factors influencing clinical outcomes of acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator显示文摘 | HUANG Yin-hui ZHUO Shi-tu CHEN Ya-fang LI Ming-mei LIN You-yu YANG Mei-li CHEN Zhen-jie CAI Ruo-wei | 2013 | Chinese Medical Journal2013，，24： | 19 |
| 18 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 19 | A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems显示文摘 | Jiantao Feng Fang Wang Xinxiao Han Zhuo Ao Quanmei Sun Wenda Hua Peipei Chen Tianwei Jing Hongyi Li Dong Han | 2014 | Nano Research2014，7，3： | 18 |
| 20 | Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure显示文摘长期的心失败(CHF ) ,源于各种各样的心血管的疾病(CVD ) 的后果的临床的症候群,逐渐地正在成为病态和死亡的一个全球原因。我们更早证明了洗旅行的一个 4 天的森林能在病人上向附属治疗学的影响提供 CHF。为了进一步调查影响和森林洗澡的最佳的频率的持续时间,与 CHF 在病人摔倒,我们招募了经历了在 4 个星期以后再洗旅行的第一个森林并且也就是,随机把他们分成了二个组的那些对象城市的控制组(城市)和洗组(森林)的森林。在洗旅行的第二个 4 天的森林以后,我们象氧化应力一样在大脑 natriuretic 肽层次,心失败的 biomarker,和稀释煽动性的回答观察了稳定的衰落。因此,这探索研究表明了添加剂好处两次,森林洗澡与 CHF 在老病人摔倒,它能进一步为在 CVD 分析如此的干预的效果铺平道路。 | MAO Gen Xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，2： | 18 |
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