|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Functional magnetic resonance imaging and the brain: A brief review显示文摘Functional magnetic resonance imaging(fMRI) is em-ployed in many behavior analysis studies, with blood oxygen level dependent-(BOLD-) contrast imaging being the main method used to generate images. The use of BOLD-contrast imaging in f MRI has been refined over the years, for example, the inclusion of a spin echo pulse and increased magnetic strength were shown to produce better recorded images. Taking careful precautions to control variables during measurement, comparisons between different specimen groups can be illustrated by f MRI imaging using both quantitative and qualitative methods. Differences have been observed in comparisons of active and resting, developing and aging, and defective and damaged brains in various studies. However, cognitive studies using f MRI still face a number of challenges in interpretation that can only be overcome by imaging large numbers of samples. Furthermore, f MRI studies of brain cancer, lesions and other brain pathologies of both humans and animals are still to be explored. | Maggie SM Chow Sharon L Wu Sarah E Webb Katie Gluskin DT Yew | 2017 | World Journal of Radiology2017，9，1： | 4 |
| 2 | TRPC3 is required for the survival, pluripotency and neural differentiation of mouse embryonic stem cells(mESCs)显示文摘Transient receptor potential canonical subfamily member 3(TRPC3) is known to be important for neural development and the formation of neuronal networks. Here, we investigated the role of TRPC3 in undifferentiated mouse embryonic stem cells(mESCs) and during the differentiation of mESCs into neurons. CRISPR/Cas9-mediated knockout(KO) of TRPC3 induced apoptosis and the disruption of mitochondrial membrane potential both in undifferentiated mESCs and in those undergoing neural differentiation. In addition, TRPC3 KO impaired the pluripotency of mESCs. TRPC3 KO also dramatically repressed the neural differentiation of mESCs by inhibiting the expression of markers for neural progenitors, neurons, astrocytes and oligodendrocytes.Taken together, our new data demonstrate an important function of TRPC3 with regards to the survival, pluripotency and neural differentiation of mESCs. | Helen Baixia Hao Sarah E. Webb Jianbo Yue Marc Moreau Catherine Leclerc Andrew L. Miller | 2018 | Science China(Life Sciences)2018，61，3： | 3 |
| 3 | Prescribing and refferral in general practice:a study of patients'expectations and doctors;actions显示文摘 | Sarah Webb Margaret Lloyd | 1994 | British Journal of General Practice1994，17，2： | 1 |
| 4 | Ca^(2+) signaling during vertebrate somitogenesis显示文摘许多 Ca2+ 信号在细胞间的脉搏和波浪形式,被报导了与 somitogenesis 的各种各样的顺序的阶段被联系:从会聚的扩展和同等轴中胚层的形成;在同等轴中胚层到的 patterning 期间建立部分单位;在整个描出的词法边界的形成部分单位,并且最后,从在是的成熟体节以内,他们经历随后的开发和区别。由于在成像提出的技术挑战,未经触动的、发展中的胚胎,和 Ca2+ transients 的微妙的性质产生了,他们证明了困难设想。然而,在将生物的活组织移植于培养基中培养和整个胚胎成像技术的有教养的房间准备和改进的联合开始揭示了发展 Ca2+ 信号的一个新、令人激动的班。在这章,我们考察小,但是膨胀,在文学和尝试报告数识别 somitogenic Ca2+ transients 的普通特征例如他们产生的模式,以及他们的空间、时间的特征。这可以帮助阐明这些吸引人的 Ca2+ transients 和 thus 的意义和函数把他们集成到安排早发展的事件的复杂发信号网络。 | Sarah E WEBB Andrew L MILLER | 2006 | Acta Pharmacologica Sinica2006，27，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员