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| 1 | Preliminary phytochemical analysis,antibacterial,antifungal and anticandidal activities of successive extracts of Crossandra infundibuliformis显示文摘Objective:To investigate the phytochemical,antibacterial,antifungal and anticandidal activity of successive extracts of Crossandra infundibuliformis(Acanthaceae) leaves.Methods:Preliminary screening on the presence of alkaloids,saponins,phytosterols,phenolic compounds,flavanoids, tannins,carbohydrates,terpenoids,oils and fats were carried out by phytochemical analysis.The antibacterial,antifungal and anticandidal activities were done by agar well diffusion technique. Results:The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0μg/mL.In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250μg/mL.Conclusions:These findings demonstrate that the leaf extracts of C.infimdibuliformis presents excellent antimicrobial activities and thus have great potential as a source for natural health care products. | Madhumitha G A.Mary Saral | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 12 |
| 2 | Green tea and the risk of gastric cancer: Epidemiological evidence显示文摘Gastric cancer (GC) is one of the leading causes of cancer death in the world. Numerous efforts are being made to find chemoprotective agents able to reduce its risk. Amongst these, green tea has been reported to have a protective effect against stomach cancer. This article aims to critically evaluate all epidemiological studies reporting an association between green tea consumption and GC risk. MEDLINE, EBSCOHOST and Google Scholar were used to search for clinical trials of green tea and its correlation to stomach cancer. Studies include cohort and case-control studies. Outcome of interests are inverse association, no association, and positive association. Seventeen epidemiologic studies were reviewed. Eleven studies were conducted in Japan, five in China, and one with Japanese descendent in Hawaii. Ten case-control studies and seven cohortstudies were included. The relative risks or odds ratio of GC for the highest level of green tea consumption was compared. Seven studies suggested no association, eight an inverse association, and one a positive association. One study had shown a significantly lowered GC risk when tea was served warm to cold. Another study also showed a significantly risk with lukewarm tea. All studies that analyzed men and women separately have suggested a reduced risk in women than in men, albeit no significant difference. This review demonstrates that there is insufficient information to support green tea consumption reduces the risk of GC. More studies on the subject matter are warranted. | I-Chun Hou Saral Amarnani Mok T Chong Anupam Bishayee | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 3 | Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey显示文摘Objective:To investigate the antibiotic resistance genes inserted into class I and class 2integrons in Acinetobacler baumannii[A.baumannii)isolates obtained from nine different cities in Turkey.Methods:A collection of 281 A.baumannii clinical isolates were collected from nine diferenl state hospitals in Turkey and were confirmed as A.baumannU by conventional biochemical,API testing and bla_(-OXA-51)specific PCR.The isolates were examined by PCR for existence of class I and2 integron gene cassettes.Results:They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin(90.03%),ciprofloxacin(87.54%),cefepime and trimethoprim/sulfamethoxazole(81.13%).The lowest resistance rates was for cefotaxime(3.55%).class 1 integrons were detected in 6.4%(18/281)of A.baumannii strains and no class 2 integron was detected.The gene casselles of class 1 inlegrons AacCI-AAC(3)l-aadAI,AacCI-aadA1,AAC(3)-I,AAC(3)-I-AAC(3)-I-aadA1,TEM-1.AAC(3)-I-aadA1-AAC(3)-I-AAC(3)-I,AAC(3)-I-AAC(3)-I-AAC(3)-I-aadA1,AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I,AAC(3)-I-aadA1-AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen strains.The aac genes family were most frequently found integrated into the class 1 inlegrons and it was followed by aadA genes and TEM-1 genes.Conclusions:This is an extensive study on the distribulion of class 1 integron among A.baumannii in Turkey.In addition to these,two new alleles were observed.Their percentage rates of similarity to other cassettes are 95%aadA1(TK A18)and 89%,aadA 1(ANKA3). | Aysegül Copur Cicek Azer Ozad Düzgün Aysegül Saral Tuba Kayman Zeynep Cizmeci Pervin Ozlem Balci Tuba Dal Mehmet Firat Ismail Tosun Yasemin Ay Alitntop Ahmet Caliskan Yelda Yazici Cemal Sandalli | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 3 |
| 4 | 中国基本药物改革:为实现最佳健康产出的选择显示文摘2009年4月,中国政府发布了《关于深化医药卫生体制改革的意见》,提出到2020年实现全民享有基本医疗卫生服务的目标。改革的重点任务之一是建立基本药物制度。在全球范围内,基本药物这一概念自1975年首次被世界卫生大会提出以来,一直具有非常重要的意义。这一概念最初强调药物的可及性和基本药物目录。但随时间推移,这一概念的内涵逐渐演变。现在各国引入基本药物概念,主要是为了确保药物可及性与可支付性、合理用药以及药物的质量和安全性。瑞典、挪威以及经合组织国家的经验表明,基本药物的概念可灵活适用于多种情形。在中国,基本药物制度的改革已取得良好成果,在非常短的时间内使公众更多获益,继续贯彻基本药物制度将有利于在中国实现最佳健康产出。 | Saral L Barber 黄宝斌 Budiono Santoso Richard Laing | 2012 | 中国卫生政策研究2012，5，7： | 3 |
| 5 | Hepatoprotective potential of petroleum ether leaf extract of Crossandra infundibuliformis on CCl_4 induced liver toxicity in albino mice显示文摘Objective:To analyze the hepatoprotective effect of the Crossandra infundibuliformis.Methods: Hepatotoxicity was induced by carbon tetrachloride.Petroleum ether extract of dried leaves was administrated to mice for 7 days.The hepatoprotective effect of petroleum ether extract was evaluated by the assay of liver function biochemical parameters.Results:The result clearly indicates that petroleum ether extract showed significant hepatoprotection when compared with standard Silumarin.Conclusions:The petroleum ether extract of the leaves of Crossandra infundibuliformis possess significant acute hepatoprotective activity.Thus further investigation on this species would bring a promising drug for liver disorders. | G Madhumitha A Mary Saral B Senthilkumar A Sivaraj | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 2 |
| 6 | Evaluation of the analgesic activity of ethyl acetate,methanol and aqueous extracts of Pleurotus eous mushroom显示文摘Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(P.eous) mushroom.Methods:The dried fruiting bodies were extracted with ethyl acetate,methanol and water.The analgesic effect of extracts of P.eous were investigated at doses 250 500 and 1 000 mg/kg body weight,using acetic-acid induced writhing,hot-plate,tail immersion and tail-clip tests.Results:P.eous extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid(P<0.05).Moreover,in hot-plate and tail immersion test,all the three extracts significantly raised the pain threshold at different time of observation(0-60 min) in comparison with control(P<0.05).In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used(P<0.05).Conclusions:The results of present study suggest that extracts of P.eous possess potent analgesic property and could serve as a base for future drugs. | Suseem SR Mary Saral A Neelakanda Reddy P Marslin Gregory | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，2： | 2 |
| 7 | Eft'eels of vhlual realily immersion anti attdiovisual distraction techniques fbr patients with pruritus 显示文摘 | Vera I Florella M Sarale C el al | 2009 | lain fes Ma mg2009，14，4： | 1 |
| 8 | Effects of virtual reality immersion and audiovisual distraction techniques for patients with pruritus显示文摘 | Vera L Florella M Sarale C et a1 | 2009 | Pain Res Manag2009，14，4： | 1 |
| 9 | Sporotrichosis successfully treated with terbinafine and potassium iodide:case report and review of the literature 显示文摘 | Coskun B Saral Y Akpolat N | 2004 | Mycopathologia2004，158，1： | 1 |
| 10 | Serologic diagnosis of syphilis:comparison of different diagnostic methods 显示文摘 | Saral Y Dilek AR Dilek N | 2012 | Acta Dermatovenerol Croat2012，20，2： | 1 |
| 11 | Tumor necrosis factor ct (-308), interleukin-6 (-174) and interleukin-10 (-1082) gene polymorphisms in polycystic ovary syndrome显示文摘 | Vural P Degirmencioglu S Saral NY | 2010 | Eur J Obstet Gyneeol Reprod Biol2010，150，1： | 1 |
| 12 | Treatment and follow-up of persistent granulomatous cheilitis with intralesional steroid and metronidazole 显示文摘 | Coskun B Saral Y Cicek D | 2004 | Dermatolog Treat2004，15，： | 1 |
| 13 | Tumor necrosis factor alpha (-308),interleukin-6(-174) and interleukin-10(-1082) gene polymorphisms in polycystic ovary syndrome显示文摘 | Vural P De?irmencio?lu S Saral NY | | 0，，01： | 1 |
| 14 | Isolation and characterisation of resistant herpes simplex virus after acyclovir therapy显示文摘 | Bums W H Saral R Santos GW | 1982 | The lance t1982，，： | 1 |
| 15 | Desai and Nirmala A Jambhekar Pathology of Ewing's sarcoma/PNET:Current opinion and emerging concepts显示文摘 | Saral S | | 0，，04： | 1 |
| 16 | Effects of virtual reality immersion and audiovisual distract-ion techniques for patients with pruritus显示文摘 | Vera L Florella M Sarale C | 2009 | Pain Res Manag2009，14，4： | 1 |
| 17 | Unique mode of GCC box recognition by the DNA-binding domain of ethyleneresponsive element-binding factor (ERF domain) in plant 显示文摘 | Hao D Y Ohmetakagi M Saral A | 1998 | J Biol Chem1998，273，： | 1 |
| 18 | Serologic diagnosis of syphilis : compari- son of different diagnostic methods 显示文摘 | Saral Y Dilek AR Dilek N | 2012 | Acta Dermatovenerol Croat2012，20，2： | 1 |
| 19 | Sporotrichosis successfully treated with terbinafine and potassium iodide:case report and review of the literature显示文摘 | Coskun B Saral Y Akpolat N | 2004 | Mycopathologia2004，158，1： | 1 |
| 20 | Effects of virtualfrality immersion and audiovisual distraction techniquesfor patients with pruritus显示文摘 | Vera L Florella M Sarale C | 2009 | Pain Res Manag2009，14，4： | 1 |
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