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您的检索式：作者名="Sarrell E. M."
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| 1 | 应用对乙酰氨基酚、布洛芬或二者交替使用对发热幼儿行解热治疗的一项随机双盲试验显示文摘Objective:To compare the antipyretic benefit of acetaminophen or ibuprofen mo notherapy with an alternating regimen of both drugs in young children aged 6 to 36 months.Design:Randomized,double-blind,parallel-group trial.Setting:Th ree primary pediatric community ambulatory centers in central Israel.Participan ts:A total of 464 children aged 6 to 36 months with fever.Intervention:Infant s were assigned to receive either acetaminophen(12.5 mg/kg per dose every 6 hou rs)(n=154)or ibuprofen(5 mg/kg per dose every 8 hours)(n=155)or to receive alternating acetaminophen and ibuprofen(every 4 hours)(n=155)for 3 days after a loading dose.Main Outcome Measures:Temperature,stress score,amount of ant ipyretic received,total days that the infant or caregiver was absent from day c are or work,respectively,at the 3-day time point,recurrence of fever,and nu mber of emergency department visits.Results:The group given the alternating re gimen was characterized by a lower mean temperature,more rapid reduction of fev er,receiving less antipyretic medication,less stress,and less absenteeism fro m day care as compared with the other groups;all of the differences were statis tically significant(P < 0.001).None of the regimens were associated with a sig nificantly higher number of emergency department visits(P=.65)or serious long-term complications(P=.66).The drug used for initial loading had no effect on outcome in any of the groups.Conclusions:An alternating treatment regimen of acetaminophen(12.5 mg/kg per dose)and ibuprofen(5 mg/kg per dose)every 4 hou rs for 3 days,regardless of the initial loading medication,is more effective t han monotherapy in lowering fever in infants and children. | Sarrell E. M. Wielunsky E. Cohen H. A. 俞晓梅(译) | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，8： | 2 |
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