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| 1 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 2 | Satoyoshi ' s syndrome:a syndrome of progressive muscle spasm,alopecia,and diarrhea显示文摘 | Satoyoshi E | | 0，，07： | 1 |
| 3 | Satoyoshi syndrome显示文摘 | Satoyoshi E | | 0，，02： | 1 |
| 4 | Recurrent muscles spasms central origine:a report of two cases显示文摘 | Yamada K | 1967 | Arch Neurol1967，16，： | 1 |
| 5 | A syndrome of progressive muscle spasm,alopecia,and diarrhea显示文摘 | | 1978 | Neurology1978，28，： | 1 |
| 6 | Agr2 mediates paracrine effects on stromat fibroblasts that promote invasion by gastric signet-ring carcinoma cells 显示文摘 | Tsuji T Satoyoshi R Aiba N | 2015 | Cancer Res2015，75，2： | 1 |
| 7 | Skeletal abnormalities in Satoyoshi's Syndrome:a radiographic study of eight cases显示文摘 | Nagano A Satoyoshi E | 1993 | Skeletal Radiology1993，22，： | 1 |
| 8 | Nerve growth factor secreted by mouse heart cells in culture显示文摘 | Furukawa S Satoyoshi E | 1984 | J Biol Chem1984，259，2： | 1 |
| 9 | Nerve growth factor secreted mouse heart cells in culture显示文摘 | Furukawa S Furukawa Y Satoyoshi E | 1984 | J Biol Chem1984，259，： | 1 |
| 10 | Synthesis and secretion of nerve growth factor by mouse astroglial cells in culture 显示文摘 | Fuurkawa S Furukawa Y Satoyoshi E | 1986 | Biochem Biophys Res Commun1986，136，： | 1 |
| 11 | Oculopharyngodistal myopathy显示文摘 | Satoyoshi E Kinoshita M | 1977 | Arch Neurol1977，34，： | 1 |
| 12 | Asporin activates coordinatedinvasion of scirrhous gastric cancer and cancer-associated fibroblasts 显示文摘 | Satoyoshi R Kuriyama S Aiba N | 2015 | Oncogene2015，34，5： | 1 |
| 13 | A syndrome of progressive muscle spasm, alopecia,and diarrhea显示文摘 | Satoyoshi E | 1978 | Neurology1978，28，5： | 1 |
| 14 | Giant cavernous hepatic hemangioma shrunk by use of sorafenib显示文摘 | Satoyoshi Yamashita Kohsuke Okita Katsunori Harada Atsuyoshi Hirano Teruaki Kimura Akira Kato Kiwamu Okita | 2013 | Clinical Journal of Gastroenterology2013，，1： | 1 |
| 15 | The Crow-Fukase syndrome: A study of 102 cases in Japan显示文摘 | Takao Nakanishi Itsuro Sobue Yasuo Toyokura Hiroshi Nishitani Yoshigoro Kuroiwa Eijiro Satoyoshi Tadao Tsubaki Akihiro Igata Yukio Ozaki | 1984 | Neurology1984，，6： | 1 |
| 16 | Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma显示文摘BACKGROUND The prognosis of hepatocellular carcinoma(HCC)patients remains poor despite advances in treatment modalities and diagnosis.It is important to identify useful markers for the early detection of HCC in patients.Preneoplastic antigen(PNA),originally reported in a rat carcinogenesis model,is increased in the tissues and serum of HCC patients.AIM To determine the diagnostic value of PNA for discriminating HCC and to characterize PNA-positive HCC.METHODS Patients with hepatitis C virus(HCV)-related hepatic disorders were prospectively enrolled in this study,which included patients with hepatitis,with cirrhosis,and with HCC.A novel enzyme-linked immunosorbent assay was developed to measure serum PNA concentrations in patients.RESULTS Serum PNA concentrations were measured in 89 controls and 141 patients with HCV infections(50 hepatitis,44 cirrhosis,and 47 HCC).Compared with control and non-HCC patients,PNA was increased in HCC.On receiver operating characteristic curve analysis,the sensitivity of PNA was similar to the HCC markers des-γ-carboxy-prothrombin(DCP)andα-fetoprotein(AFP),but the specificity of PNA was lower.There was no correlation between PNA and AFP and a significant but weak correlation between PNA and DCP in HCC patients.Importantly,the correlations with biochemical markers were completely different for PNA,AFP,and DCP;glutamyl transpeptidase was highly correlated with PNA,but not with AFP or DCP,and was significantly higher in PNA-high patients than in PNA-low patients with HCV-related HCC.CONCLUSION PNA may have the potential to diagnose a novel type of HCC in which glutamyl transpeptidase is positively expressed but AFP or DCP is weakly or negatively expressed. | Satoyoshi Yamashita Akira Kato Toshitaka Akatsuka Takashi Sawada Tomohide Asai Noriyuki Koyama Kiwamu Okita | 2020 | World Journal of Gastroenterology2020，26，13： | 1 |
| 17 | Recurrent muscles spasms central origine: a report of two ca:s显示文摘 | Satoyoshi E Yamada K | 1967 | Al'ch Neurol1967，16，： | 1 |
| 18 | Giant cavernous hepatic hemangioma shrunk by use of sorafenib显示文摘 | Satoyoshi Yamashita Kohsuke Okita Katsunori Harada Atsuyoshi Hirano Teruaki Kimura Akira Kato Kiwamu Okita | 2013 | Clinical Journal of Gastroenterology2013，，1： | 1 |
| 19 | Extracellular processing of dentin matrix protein in the nineralizing odontoblast culture显示文摘 | Satoyoshi M Koizumi T Teranaka T | 1995 | Calcify Tissue Int1995，57，： | 1 |
| 20 | Extracellular processing of dentin matrix protein in the mineralizing odontoblast culture显示文摘 | Satoyoshi M Koizumi T Iwamoto T | 1995 | Calcif Tissue Int1995，57，3： | 1 |
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