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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Credit ratings and the BIS capital adequacy reform agenda 显示文摘 | Altman E I Bharath S T Saunders A | 2002 | Journal of Banking & Finance2002，26，9： | 2 |
| 3 | Atomic decomposition by basis pursuit显示文摘 | CHEN S B DONOHO D L SAUNDERS M A | | 0，，01： | 2 |
| 4 | A high performance satellite data modem using real-time digital signal processing techniques显示文摘 | Allan R D Bramwell J R Saunders D A | 1988 | J IERE1988，58，3： | 2 |
| 5 | Relation of tumor content of estrogen and progesterone receptors with response of patients to endocrine therapy显示文摘 | Brooks SC Saunders DE Singhakowinta A | 1980 | Cancer1980，46，12： | 2 |
| 6 | Financial institutions Management: A Modem Perspective显示文摘 | Saunders A | 1999 | New York: The McGraw-Hill1999，，： | 1 |
| 7 | Downsizing,delayering-but where is the commitment? The development of a diagnostic tool to help management survivors显示文摘 | THORNHILL A SAUNDERS M N K STEAD J | 1997 | Personnel Review1997，26，12： | 1 |
| 8 | Prevention of cisplatin-induced nephrotoxicosis in dogs, using hypertonic saline solution as the vehicle of administration显示文摘 | FORRESTER S D FALLIN E A SAUNDERS G K | 1993 | Am J Vet Res1993，54，12： | 1 |
| 9 | Identification and comparison of aerobic and denitrifying polyphosphateaccumulating organisms显示文摘 | Zeng R J Saunders A M Yuan Z G | 2003 | Biotechnol Bioeng2003，83，2： | 1 |
| 10 | The surgical treatment of type II diabetes mellitus:changes in HOMA Insulin resistance in the first year following laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB)显示文摘 | Ballantyne G H Wasielewski A Saunders J K | 2009 | Obesity Surgery2009，19，9： | 1 |
| 11 | Effect of lake trophic status and rooted macrophytes on community composition and abundance of ammonia-oxidizing prokaryotes in freshwater sediments显示文摘 | Herrmann M Saunders A M Schramm A | 2009 | Appl Environ Microbiol2009，75，10： | 1 |
| 12 | A randomised multicentre trial显示文摘 | Saunders M Dische S Barrett A et aL Continuous hyperfractionaed accelerated radiotherapy(CHART)versus conventional radiotherapy in non-small-cell lung cancer | 1997 | Lancet1997，350，9072： | 1 |
| 13 | Typing of Listeria monocytogenes for epidemiological studies using DNA probes显示文摘 | SAUNDERS N A RIDLEY A M TAYLOR A G | 1989 | Acta Microbiol Hung1989，，36： | 1 |
| 14 | Atomic decomposi- tion by basis pursuit 显示文摘 | Chen S S Donoho D L Saunders M A | 1999 | SIAM Journal on Scientific Computing1999，20，1： | 1 |
| 15 | Reactive oxygenspecies mediate lysophosphatidic acid induced signaling in ovarian cancer cells显示文摘 | Saunders J A Rogers L C Klomsiri C | | 0，，12： | 1 |
| 16 | Emmetropisation following pretemn birth显示文摘 | Saunders K J McCulloch DL Shepherd A J | 2002 | Br J Ophthalmol2002，86，9： | 1 |
| 17 | A Mantle Plume Origin for the Siberian Traps:Uplift and Extension in the East Siberian Ba- sin, Russia显示文摘 | SAUNDERS A D ENGLAND R W REICHOW M K | 2005 | Lithos2005，79，3： | 1 |
| 18 | Atomic decom-position by basis pursuit 显示文摘 | Chen S S Donoho D L and Saunders M A | 1999 | SIAM Journal on Scientific Computing1999，20，1： | 1 |
| 19 | Atomic decomposition by basis pursuit 显示文摘 | CHEN S DONOHO D L SAUNDERS M A | 1999 | SIAM Journal on Scientific Computing1999，20，1： | 1 |
| 20 | Aging of the adult human brain:in vivo quantitation of metabolite content with proton magnetic resonance spectroscopy显示文摘 | Dawn E Saunders MD Franklyn A | 1999 | JMRI1999，5，： | 1 |
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