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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Charge separation during the fragmentation of rime and frost 显示文摘 | Saunders C P R Hickson H Malone M D Richtofen J V | 1993 | Atmospheric Research1993，83，： | 1 |
| 3 | Human urocortin II, a new CRF -related peptide, displays selective CRF (2) -mediated action on gastric transit in rats 显示文摘 | Million M Maillot C Saunders P | 2002 | Am J Physiol Gastrointest Liver Physiol2002，282，1： | 1 |
| 4 | Uncertainty Budgets for Calibration of Radiation Thermometers below the Silver Point 显示文摘 | Saunders P Fischer J Sadli M | 2008 | Int J Thermophys2008，29，3： | 1 |
| 5 | Spatial aggrega tion and temporal migration of free-living stages of the parasitic nematode Trichostrongylus tenuis 显示文摘 | Saunders L M Tompkins D M Hudson P J | 2000 | Functional Ecology2000，14，： | 1 |
| 6 | Three-body wear associated with three ceramics and enamel 显示文摘 | Al-Hiyasat A S Saunders W P Smith G M | 1999 | J Prosthet Dent1999，82，： | 1 |
| 7 | A note on a sufficient-decrease criterion for a nonderivative steplength procedure 显示文摘 | Gill E P Murry Saunders W Wright H M | 1982 | Mathematical Programming1982，23，： | 1 |
| 8 | SNOPT: an sqp algorithm for large-scale constrained optimization 显示文摘 | Gill P E Murray W Saunders M A | 2002 | SIAM Joumal on Optimization2002，12，4： | 1 |
| 9 | Impact on survival of intensive follow up after curative resection for colorectal cancer:systematic review and meta-analysis of randomized trials显示文摘 | Renehan A G Egger M Saunders M P | 2002 | Br Med J2002，324，： | 1 |
| 10 | Molecularbiological effects of selective neuronal nitric oxide synthase inhibitionin ovine lung injury 显示文摘 | Saunders FD WestpKal M Enkhbaatar P | 2010 | Am J Physiol Lung Cell Mol Physiol2010，298，3： | 1 |
| 11 | Impact on survival of intensive follow-up after curative resection for colorectal cancer:Systematic review and meta-analysis of randomized trials显示文摘 | Renehan A G Egger M Saunders M P | 2002 | BMJ2002，324，： | 1 |
| 12 | An evolutionary algorithm that constructs recurrent neural networks 显示文摘 | Angeline P J Saunders G M Pollack J B | 1994 | IEEE Trans on Neural Networks1994，5，1： | 1 |
| 13 | Uncertainty budgets for calibration of radiation thermometers below the silver point 显示文摘 | Saunders P Fischer J Sadli M | 2008 | Int J Thermophys2008，29，3： | 1 |
| 14 | Compound 338-86-15,a novel peptide CRF-R2 antagonist,selectively blocks CRF and stress-induced delayed gastric emptying in rats显示文摘 | Million M Saunders P Rivier J | 2001 | Soc Neurosci Abstr2001，27，： | 1 |
| 15 | An improved fast radiative transfer model for assimilation of satellite radi- ance observations 显示文摘 | Saunders R Matrieardi M Brunel P | 1999 | Quarterly Journal of the Royal Meteorological Society1999，125，556： | 1 |
| 16 | An evolutionary algorithm that constructs recurrent neural networks显示文摘 | Angeline P J Saunders G M Pollack J B | 1994 | IEEE Transactions on Neural Networks1994，5，1： | 1 |
| 17 | Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine显示文摘 | Saunders P R Kosecka U McKay D M | 2007 | Am J Physiol Gastrointest2007，267，5： | 1 |
| 18 | Comparison of barriers of self - emcacy and perceived be- havioral control for explaining physical activity across 1 year among adolescent girls 显示文摘 | Moil RW Dishman R K Ward D S Saunder R P Dowda M Felton G | 2005 | Health Psychology2005，，24： | 1 |
| 19 | Grape cane gallmaker (Coleoptera:Curculionidae) and its impact on cultivated grapes 显示文摘 | SAUNDERS M C TOBIN P C | 2000 | Journal of Economic Entomology2000，93，3： | 1 |
| 20 | An evalutionary algorithm that constructs recurrent neural networks显示文摘 | Saunders G M Pollack J B | 1994 | IEEE Trans on Neural Network1994，5，1： | 1 |
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