|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antiplatelet therapy in very elderly and comorbid patients with acute coronary syndromes显示文摘With population ageing and rise of life expectancy,a progressively increasing proportion of patients presenting with an acute coronary syndrome(ACS)are older adults,including those at extreme chronological age.Increasing amounts of data,including randomized clinical trials,have shown that the benefits of an early revascularization are maintained also at very old age,resulting in improved outcome after an acute coronary event.On the contrary,the optimal antiplatelet therapy(APT)remains unclear in these patients,because of both safety and efficacy concerns.Indeed,age-related multiple organ dysfunction and high prevalence of comorbidities may on the one hand reduce the therapeutic effects of administered drugs;on the other hand,it leads to increased vulnerability to drug toxicity and side effects.Therefore,management of APT is particularly challenging in elderly patients because of higher risk of both ischemic and bleeding events.The aim of the present paper is to review the current evidence,gaps in knowledge and ongoing research regarding APT in the setting of an ACS in elderly and very elderly patients,and in those with significant comorbidities including chronic kidney disease,diabetes mellitus and frailty. | Roberta De Rosa Federico Piscione Gennaro Galasso Stefano De Servi Stefano Savonitto | 2019 | Journal of Geriatric Cardiology2019，16，2： | 4 |
| 2 | 急性心肌梗死阿昔单抗、瑞替普酶、支架联合研究(CARESS-in-AMI)中的即刻恤管成形术与常规治疗联合挽救性血管成形术的比较:一项前瞻性、开放、多中心随机试验显示文摘背景当90min内不能进行直接经皮冠状动脉介入术(PCI)时,溶栓就仍是ST段抬高型心肌梗死(STEMI)的治疗选择。然而,溶栓治疗之后患者的最佳后续处理仍不确定。为了评估最佳处理方案,作者把在非介入医院用溶栓和阿昔单抗治疗的STEMI患者随机分为即刻进行PCI与常规药物治疗联合挽救性血管成形术两组。
方法给予法国、意大利和波兰等国家的600例年龄≤75岁、有≥1项高危特征(广泛性ST段抬高、新发左柬支传导阻滞、既往有心肌梗死、Killip分级≥2级或左室射血分数≤35%)的住院患者半量瑞替普酶、阿昔单抗、肝素和阿司匹林治疗,并随机分配为转诊至最近的介入中心进行即刻PCI或仅在持续ST段抬高、临床征象加重时转诊。主要结局为30d时死亡、再梗死或顽固性心肌缺血的复合指标,采用意向治疗分析。研究在Clinical Trials.gov的注册编号为00220571。
结果分配至即刻PCI组的299例患者中,289例(97.0%)进行了血管造影,255例(85.6%)进行了PCI。在常规治疗/挽救性PCI组中有91例(30.3%)患者进行了挽救性PCI。即刻PCI组出现主要结局指标的患者为13例(4.4%),而常规治疗辟乞救性PCI组为32例(10.7%)(HR0-40,95%C10.21~0.76;对数秩检验P=0.004)。即刻PCI组严重出血患者为10例,而常规治疗/挽救性PCI组为7例(3.4%vs2.3%,P=0.47)。即刻PCI组卒中患者为2例.而常规治疗/挽救性PCI组为4例(0.7%vs 1.3%.P=0.50)。
结论 在非介入中心,采用半量瑞替普酶和阿昔单抗治疗的高危STEMI患者即刻转诊进行PCI可改善结局。 | Carlo Di Maria Dariusz Duded Federico Piscione Waldemar Mielecki Stefano Savonitto Ernesto Murena Konstantinos Dimopoulos 郭占宏(译) | 2008 | 世界临床医学2008，2，5： | 3 |
| 3 | Prognostic value of the admission electrocardiogram in acute coronary syndromes 显示文摘 | Savonitto S Ardisino D Granger CB | 1999 | JAMA1999，281，： | 1 |
| 4 | Prognostic value of the admission electrocardiogram in acute coronary syndromes显示文摘 | SAVONITTO S ARDISSIMO D GRANGER C B | 1999 | JAMA1999，281，8： | 1 |
| 5 | Impact of acute renal failure following percutaneous coronary intervention on long-term mortality 显示文摘 | ROGHI A SAVONITTO S CAVALLINI C | 2008 | J Cardiovasc Med (Hagerstown)2008，9，4： | 1 |
| 6 | Prognostic val- ue of isolated troponin I elevation after percutaneous coro- nary intervention显示文摘 | Cavallini C Verdecchia P Savonitto S | 2010 | Circ Cardiovasc Interv2010，3，5： | 1 |
| 7 | Treatment of Acute Coronary Syndromes in the Elderly and in Patients With Comorbidities显示文摘 | Stefano Savonitto Nuccia Morici Stefano De Servi | 2014 | Revista Espa?ola de Cardiología (English Edition)2014，，： | 1 |
| 8 | Prognostic significance of creatine kinase release after percutaneous coronary intervention显示文摘 | Cavallini C Rugolotto M Savonitto S | 2005 | Ital Heart J2005，6，6： | 1 |
| 9 | The elderly with acute coronary syndrome: the higher the risk, the lesser the treatment 显示文摘 | SAVONITTO S COLOMBO P BOSSI I | 2006 | G Ital Cardiol(Rome)2006，7，： | 1 |
| 10 | Prognostic value of i solated troponin I elevation after percntaneous coronary interven- tion显示文摘 | Cavallini C Verdecchia P Savonitto S | 2010 | Circ Cardiovase Intcrv2010，3，15： | 1 |
| 11 | Plavor generation in cheese curd by cocolturing with sciecied yeast,mold and hacteria显示文摘 | MARTIN N SAVONITTO S | 1999 | J Dairy Sci1999，，6： | 1 |
| 12 | Management of patients with re- cently implanted coronary stents on dual antiplatelet therapy who need to undergo major surgery显示文摘 | Savonitto S Caracciolo M Cattaneo M | 2011 | Thromb Haemost2011，9，： | 1 |
| 13 | Risk factors for fatal road traffic accidents in Udine,Italy显示文摘 | Valent F Schiava F Savonitto C | 2002 | Accid Anal Prey2002，34，1： | 1 |
| 14 | Early aggressive versus initially conservative treatment in elderly patients with non-ST-seg-ment elevation acute coronary syndrome:a randomized controlled trial 显示文摘 | Savonitto S Cavallini C Petronio AS | 2012 | Am J Cardiol2012，5，9： | 1 |
| 15 | Impact of the elevation of biochemical markers of myocardial damage on long-term mortality after percutaneous coronary intervention: results of the CK-MB and PCI study显示文摘 | Cavallini C Savonitto S Violini R | 2005 | European Heart Journal2005，26，15： | 1 |
| 16 | Lack of correlation between activation of bemostatic mechanism and inflammation in unstable angina pectoris显示文摘 | Oltrona L Merlini P A Savonitto S | 1998 | J Thromb Thrombelysis1998，5，： | 1 |
| 17 | Prognostic value of admission electrocardiogram in acute coronary syndromes显示文摘 | Savonitto S Ardissino D Granger CB | 1999 | JAMA1999，281，8： | 1 |
| 18 | Urgent surgery in patients with a recently implanted coronary drug-eluting stent: a phase Ⅱ study of' bridging' antiplatelet therapy with tirofiban during temporary withdrawal of clopidogrel 显示文摘 | Savonitto S D' Urbano M Caraceiolo M | 2010 | Br J Anaesth2010，104，： | 1 |
| 19 | Urgent surgery in patients with a recently implanted coronary drug-eluting stent:a phase Ⅱstudy of ′bridging′ antiplatelet therapy with tirofiban during temporary withdrawal of clopidogrel显示文摘 | Savonitto S D′Urbano M Caracciolo M | 2010 | Br J Anaesth2010，104，3： | 1 |
| 20 | Risk factor for road trafficaccident in Udine, Italy 显示文摘 | Valent F Schiava F Savonitto C | 2002 | Accid Anal Prev2002，34，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员