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| 1 | Hepatoid adenocarcinoma of the colon in a patient with inflammatory bowel disease显示文摘A case is presented of a 36-year-old male with primary sclerosing cholangitis-associated inflammatory bowel disease(PSC-IBD) and two synchronous stage 1 adenocarcinomata of the colon,who was initially treated with a subtotal colectomy with ileostomy.One year later,the patient presented with extensive intra-abdominal lymphadenopathy and peritoneal carcinomatosis,as well as a markedly elevated serum level of alpha-fetoprotein(AFP).Fine needle aspiration biopsy of a porta hepatis lymph node revealed a metastatic hepatoid adenocarcinoma.Subsequent review of the previous colectomy specimen showed that one of the previously identified adenocarcinomata had features suggestive of a hepatoid colonic adenocarcinoma.The patient was subsequently treated with a cytotoxic regimen of FOLFOX(oxaliplatin,leucovorin,5-fluorouracil) and bevacizumab,with stable results being achieved after six months.This case presents the first known report of PSC-IBD associated with synchronous typical and hepatoid adenocarcinomata of the colon and highlights the importance of considering hepatoid adenocarcinoma as a differential diagnosis in patients with an increasing serum AFP level. | Yuanyuan Chen David F Schaeffer Eric M Yoshida | 2014 | World Journal of Gastroenterology2014，20，35： | 6 |
| 2 | Factor Xa activates endothelial cells by a receptor cascade between EPR-1 and PAR2显示文摘 | Bono F Schaeffer P Herault J P | 2000 | Arterioscler Thromb Vasc Biol2000，20，11： | 1 |
| 3 | Potential for reduction of CO2 emissions and a low-carbon scenario for the Brazilian industrial sector显示文摘 | Henriques J M FDantas F Schaeffer R | | 0，，04： | 1 |
| 4 | DNA-stacking interactions determine the sequence specificity of the deoxyribonuclease activity of 1,10-phenanthroline-copperion显示文摘 | Schaeffer F Rimsky S Spassky A | 1996 | J Mol Biol1996，260，： | 1 |
| 5 | Incidence of local recurrence and port site metastasis after 显示文摘 | MUNTENER M SCHAEFFER E M ROMERO F R | 2007 | Urology2007，70，： | 1 |
| 6 | Structural plasticity and distinct drug-bindingmodes of LfrR, a mycobacterial efflux pump regulator 显示文摘 | BELLINZONI M BURONI S SCHAEFFER F | 2009 | JBacteriol2009，191，24： | 1 |
| 7 | Tumor expression of Integrin-linked kinase correlates with the expression of the E-cadherin repressor Snail:an immunohistochemical study in ductal pancreatic adenocarcinoma显示文摘 | Schaeffer D F Assi K Chan K | 2010 | Virchows Arch2010，456，3： | 1 |
| 8 | Deficiency of survivin in transgenic mice exacerbates Fas induced apoptosis via mitochondrial pathways显示文摘 | Conway EM Pollefeyt S Steiner - Mosonyi M Lno W Dereriese A Lupu F Bono F Leducq N Dol F Schaeffer P Collen D Herbet JM | 2002 | Gastroenterology2002，123，： | 1 |
| 9 | Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma显示文摘 | Schaeffer D F Assi K Chan K | 2010 | Virchows Arch2010，456，3： | 1 |
| 10 | Synergy of entry inhibitors with direct-Acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C显示文摘 | Xiao F Fofana I Thumann C Mailly L Alles R Robinet E Meyer N Schaeffer M Habersetzer F Doffol M Leyssen P Neyts J Zeisel M B Baumert T F | 2014 | Gut2014，，： | 1 |
| 11 | Expression of insulin-like growth factor 2 in mesenchymal neoplasms 显示文摘 | Steigen S E Schaeffer D F West R B | 2009 | Modem Pathology2009，22，7： | 1 |
| 12 | Insights into Alzheimer disease pathogenesis from studies in transgenic an- imal models 显示文摘 | Schaeffer E L Figueiro M Gattaz W F | 2011 | Cncs2011，66，1： | 1 |
| 13 | Factor Xa activates endothelial cells by a receptor cascade between EPR-I and PAR-2 显示文摘 | BONO F SCHAEFFER P | 2000 | Arterioscler Thromb Vasc Biol2000，20，11： | 1 |
| 14 | DNA-stacking interactions determine the sequence specificity of the deoxyribonuclease activity of 1,10-phenanthroline-copper ion显示文摘 | Schaeffer F Rimsky S Spassky A | 1996 | J Mol Biol1996，260，： | 1 |
| 15 | Detection and quantitation of noroviruses in shellfish 显示文摘 | LE GUYADER F S PARNAUDEAU S SCHAEFFER J | 2009 | Applied and Environmental Microbiology2009，75，3： | 1 |
| 16 | An Amino Acid Substitution in the Pore Region of a Glutamate-gated Chloride Channel Enables the Coupling of Ligand Binding to Channel Gating 显示文摘 | ETTER A CULLY D F SCHAEFFER J M | 1996 | J Biol Chem1996，271，16： | 1 |
| 17 | DNA-stacking interactions determine the sequence specificity of the deoxyribonuclease activity of 1,10-phenanthroline-copper ion显示文摘 | Schaeffer F Rimsky S Spassky A | 1996 | J Mol Biol1996，260，： | 1 |
| 18 | Bayesian inference for categorical traits with an application to variance component estimation 显示文摘 | LuoM F Boettcher P J Schaeffer L R etal | 2001 | Journal of Dairy Science2001，84，3： | 1 |
| 19 | Effects of chloralhydrate on passive respiratory mechanics in infants显示文摘 | Schaeffer D Cerny F | 1985 | Physiologist1985，28，： | 1 |
| 20 | Expres- sion of insulin-like growth factor 2 in mesenchymal neoplasms显示文摘 | Steigen Sonja E Schaeffer David F West Robert B | 2009 | Mod Pathol2009，22，7： | 1 |
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