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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | Cytokinins play opposite roles in lateral root formation, and nematode and rhizobial symbioses 显示文摘 | Lohar D P Schaff J E Laskey J G | 2004 | The Plant Journal : for Cell and Molecular Biology2004，38，2： | 1 |
| 3 | Repeating seismic events in China 显示文摘 | Schaff D P Richards P G | 2004 | Science2004，303，： | 1 |
| 4 | Hepatitis viruses and hepatoearcinogenesis 显示文摘 | Lotz G Kiss A Novak PK Schaff Z | 2001 | Physiol Paris2001，95，16： | 1 |
| 5 | Cytokinins play opposite roles in lateral root formation,and nematode and rhizobial symbioses显示文摘 | LOHAR D P SCHAFF J E LASKEY J G | 2004 | Plant Journal2004，38，： | 1 |
| 6 | Optimizing correlation techniques for improved earthquake location显示文摘 | Schaff D P Bokelmann G H R Ellsworth W L | 2004 | Bulletin of the Seismological Society of America2004，94，2： | 1 |
| 7 | Cytokinins play oppositeroles in lateral root formation, and nematode and rhizobial syrnbioses显示文摘 | Lohar D P Schaff J E laskey J G | 2004 | The Plant Journal2004，38，2： | 1 |
| 8 | Repeating seismic events in China显示文摘 | Schaff D P Richards P G | 2004 | Science2004，303，： | 1 |
| 9 | Effect of Ischemic Preconditioning on Rat Liver Microcirculation Monitored with Laser Doppler Flowmetry显示文摘 | Attila Szijártó Oszkár Hahn Gábor Lotz Zsuzsa Schaff Emilia Madarász Péter Károly Kupcsulik | 2006 | Journal of Surgical Research2006，，1： | 1 |
| 10 | Quantitative cell biology with the Virtual Cell显示文摘 | Slepchenko B M Schaff J C Macara I G | 2003 | Trends in Cell Biology2003，13，11： | 1 |
| 11 | A three-dimensional model of hepatitis delta virus ribozyme based on biochemical and mutational analyses 显示文摘 | Tanner N K Schaff G Thill E | 1994 | Curt Biol1994，4，： | 1 |
| 12 | Cytokinins play opposite roles in lateral root formation, nematode and Rhizobial symbioses显示文摘 | Lohar D P Schaff J E Laskey J G | 2004 | Plant J2004，38，： | 1 |
| 13 | Claudins as diagnostic and prognostic markers in gynecological cancer 显示文摘 | Szabo I Kiss A Schaff Z Sobel G | 2009 | Histol His- topathol2009，24，12： | 1 |
| 14 | Surgical treatment of tricuspid insufficiency late after mitral valve replacement显示文摘 | KING R M SCHAFF H V DANIELSON G K | 1983 | Circulation1983，68，： | 1 |
| 15 | ZmYS1 functions as a proton-coupled symporter for phytosiderophore and nicotianamine-chelated metals显示文摘 | SCHAFF G LUDEWIG U ERENOCALU BE | 2004 | Bid Chem2004，279，： | 1 |
| 16 | Long-term outcome of surgical repair of ruptured sinus of valsalva aneurysm显示文摘 | VAN SON J A DANIELSON G K SCHAFF H V | 1994 | Circulation1994，90，： | 1 |
| 17 | Long- term outcome of surgical repair of ruptured sinus of Valsalva aneurysm显示文摘 | vanSon J A Danielson G K Schaff H V | 1994 | Circulation1994，90，20： | 1 |
| 18 | Coseismic and postseismic velocity changes measured by repeating earth quakes显示文摘 | Schaff D P Beroza G C | 2004 | Journal of Geophysical Research2004，109，10： | 1 |
| 19 | Outcome of pulmonary and aortic homografts for right ventricular outflow tract reconstruction 显示文摘 | BANDO K DANIELSON G K SCHAFF H V et el | 1995 | J Thorac Cardiovasc Surg1995，109，3： | 1 |
| 20 | A three-dimensional model of hepatitis delta virus ribozyme based on biochemical and mutational analyses 显示文摘 | Tanner N K Schaff S Thill G etal | 1994 | Current Biology1994，4，8： | 1 |
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