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| 1 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 2 | Proteomics and renal transplantation:searching for novel biomarker and therapeutic targets显示文摘 | Schaub S Wilkins JA Nickerson P | 2008 | Contrib Nephrol2008，160，1： | 1 |
| 3 | Commisioning and First Operating Experience at Darlington Tritium Removal Facility显示文摘 | Davidson R B Hatten P V Schaub M | 1988 | Fusion Technol1988，14，： | 1 |
| 4 | System-level tests of transformer differential protection using an IEC 61850 process bus显示文摘 | INGRAM M E SCHAUB P TAYLOR R R | 2014 | IEEE Transactions on Power Delivery2014，29，3： | 1 |
| 5 | Soil respiration and soil microbial biomass after fire in a sweet chestnut forest in southern Switzerland 显示文摘 | Wüthrich C Schaub D Weber M Marxer P Conedera M | 2002 | Catena2002，48，3： | 1 |
| 6 | Higher order cayley transformation application to attitude repre- sentations显示文摘 | Tsiotras P Junkins J L Schaub H | 1997 | Journal of Guidance Control and Dynamics1997，20，3： | 1 |
| 7 | Commissioning and first operating experience at Darlington tritium removal facility 显示文摘 | DAVIDSON R B HATTEN P V SCHAUB M | 1988 | Fusion Technology1988，14，22： | 1 |
| 8 | Local debris congestion in thegeosynchronous environment with population augmentation显示文摘 | Anderson P V Schaub H | 2014 | Acta Astronautica2014，94，2： | 1 |
| 9 | An antimalarial alkaloid from hydrangea XV Synthesis of 5-, 6-, 7-, and 8-derivatives with two identical substituents显示文摘 | BAKER B R SCHAUB R E JOSEPH J P | 1952 | J Org Chem1952，17，1： | 1 |
| 10 | Commisioning and First Operating Experience at Darlington Tritium Removal Facility显示文摘 | Davidson R B Hatten P V Schaub M | 1988 | Fusion Technol1988，14，22： | 1 |
| 11 | Shared mental models--linking team cognition and performance显示文摘 | R BIERHALS I SCHUSTER P KOHLER P BADKE SCHAUB | 2007 | CoDesign2007，，3： | 1 |
| 12 | Instrumenta- tion and method for ultrahigh resolution field desorption ioni- zation Fourier transform ion cyclotron resonance mass spec- trometry of nonpolar species显示文摘 | Schaub T M Hendrickson C L Quinn J P | 2005 | Analytical Chemistry2005，77，5： | 1 |
| 13 | Commisioning and first operating experience at Darlington Tritium Removal Facility 显示文摘 | Davidson R B Hatten P V Schaub M | 1988 | Fusion Tech1988，14，2： | 1 |
| 14 | Modeling of deformation around magmatic intrusions with ap- plication to gold-related structures in the Yilgarn Cra- ton, Western Australia显示文摘 | Zhang Y Karrech A Schaubs P M | 2012 | Tectonophysics2012，，： | 1 |
| 15 | Leptin prevents respiratory depression in obesity显示文摘 | O'donnell C P Schaub C D Haines A S | 1999 | Am J Respir Crit Care Med1999，159，5： | 1 |
| 16 | Why Is Golden Rice Golden (Yellow) Instead of Red?显示文摘 | Schaub P | 2005 | Plant Physiology2005，138，1： | 1 |
| 17 | A general framework for expressing preferences in causal reasoning and planning显示文摘 | DELGRANDE J P SCHAUB T TOMPITS H | 2007 | Journal of Logic and Computation2007，17，5： | 1 |
| 18 | Commisioning and first operating experienee at darlington tritium removal facility显示文摘 | DAVIDSON R B HATTEN P V SCHAUB M | 1988 | Fusion Technol1988，14，22： | 1 |
| 19 | Commissioning and first operating ex- perience at Darlington Tritium Removal Facility 显示文摘 | DAVIDSON R B HATTEN P V SCHAUB M | 1988 | Fusion Technology1988，14，2： | 1 |
| 20 | CHO gene ex- pression profiling in biopharmaceutical process analysis and de- sign 显示文摘 | SCHAUB J CLEMENS C SCHORN P | 2010 | Biotechnol Bioeng2010，105，2： | 1 |
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