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| 1 | Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors显示文摘AIM:To determine the prevalence and characteristics of bile reflux in gastroesophageal reflux disease(GERD) patients with persistent symptoms who are non-responsive to medical therapy.METHODS:Sixty-five patients(40 male,25 female;mean age,50 ± 7.8 years) who continued to report symptoms after 8 wk of high-dose proton pump inhibitor(PPI) therapy,as well as 18 patients with Barrett's esophagus,were studied.All patients filled out symptom questionnaires and underwent endoscopy,manometry and combined pH-metry and bilimetry.RESULTS:There were 4 groups of patients:22(26.5%) without esophagitis,24(28.9%) grade A-B esophagitis,19(22.8%) grade C-D and 18(21.6%) Barrett's esophagus.Heartburn was present in 71 patients(85.5%) and regurgitation in 55(66.2%),with 44(53%) reporting simultaneous heartburn and regurgitation.The prevalence of pathologic acid reflux in the groups without esophagitis and with grades A-B and C-D esophagitis was 45.4%,66.6% and 73.6%,respectively.The prevalence of pathologic bilirubin exposure in these 3 groups was 53.3%,75% and 78.9%,respectively.The overall prevalence of bile reflux in non-responsive patients was 68.7%.Pathologic acid and bile reflux was observed in 22.7% and 58.1% of non-esophagitic patients and esophagitic patients,respectively.CONCLUSION:The high percentage of patients poorly responsive to PPI therapy may result from poor control of duodenogastroesophageal reflux.Many patients without esophagitis have simultaneous acid and bile reflux,which increases with increasing esophagitis grade. | Luigi Monaco Antonio Brillantino Francesco Torelli Michele Schettino Giuseppe Izzo Angelo Cosenza Natale Di Martino | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 2 | Laparoscopic calibrated total vs partial fundoplication following Heller myotomy for oesophageal achalasia显示文摘AIM:To compare the mid-term outcomes of laparoscopic calibrated Nissen-Rossetti fundoplication with Dor fundoplication performed after Heller myotomy for oesophageal achalasia.METHODS:Fifty-six patients(26 men,30 women;mean age 42.8±14.7 years)presenting for minimally invasive surgery for oesophageal achalasia,were enrolled.All patients underwent laparoscopic Heller myotomy followed by a 180°anterior partial fundoplication in 30 cases(group 1)and calibrated NissenRossetti fundoplication in 26(group 2).Intraoperative endoscopy and manometry were used to calibrate the myotomy and fundoplication.A 6-mo follow-up period with symptomatic evaluation and barium swallow was undertaken.One and two years after surgery,the patients underwent symptom questionnaires,endoscopy,oesophageal manometry and 24 h oesophago-gastric pH monitoring.RESULTS:At the 2-year follow-up,no significant difference in the median symptom score was observed between the 2 groups(P=0.66;Mann-WhitneyU-test).The median percentage time with oesophageal pH< 4 was significantly higher in the Dor group compared to the Nissen-Rossetti group(2;range 0.8-10 vs 0.35;range 0-2)(P<0.0001;Mann-WhitneyU-test).CONCLUSION:Laparoscopic Dor and calibrated Nissen-Rossetti fundoplication achieved similar results in the resolution of dysphagia.Nissen-Rossetti fundoplication seems to be more effective in suppressing oesophageal acid exposure. | Natale Di Martino Antonio Brillantino Luigi Monaco Luigi Marano Michele Schettino Raffaele Porfidia Giuseppe Izzo Angelo Cosenza | 2011 | World Journal of Gastroenterology2011，17，29： | 4 |
| 3 | Inventive productivity and patent quality: evidence from italian inventors 显示文摘 | Schettino F Sterlacchini A Ventuini F | 2013 | Journal of Policy Modeling2013，35，6： | 1 |
| 4 | Solid-state culture of Aspergillus niger on support显示文摘 | Oriol E Schettino B Viniegra-Gonzales G | 1988 | Journal of Fermentation Technology1988，66，1： | 1 |
| 5 | Endoscopic endonasal removal of an intra-suprasellar Rathke s cleft cyst: case report and surgical considerations显示文摘 | Alfieri A Schettino R Tarfani A | 2002 | Minim Invasive Neurosurg2002，45，： | 1 |
| 6 | The use of xenografi models for the selection of cancer treatments with the EGFR as an example显示文摘 | Troiani T Schettino C Martinelli E | 2008 | Crit Rev Oncol Hematol2008，65，3： | 1 |
| 7 | Surface-enhanced Raman spectra of pyridine and pyrazolide on silver colloids:chemical and electromagnetic effects显示文摘 | Muniz-Miranda M Cardini G Schettino V | 2004 | Theoretical Chemistry Accounts2004，111，： | 1 |
| 8 | Determinants of envi- ronmentally responsible behavior 显示文摘 | Borden R J Schettino A P | 1979 | Journal of Environmental Education1979，10，4： | 1 |
| 9 | Treatment of advanced non-small cell lung cancer 显示文摘 | Bareschino MA Schettino C Rossi A | 2011 | J Thorac Dis2011，3，2： | 1 |
| 10 | Treatment of advanced non small cell lung cancer显示文摘 | Bareschino MA Schettino C Rossi A | | 0，，02： | 1 |
| 11 | Erlotinib in cancer treatment 显示文摘 | Bareschino MA Schettino C Troiani T | 2007 | Ann Oncol2007，18，6： | 1 |
| 12 | Treatment of advanced non small cell lung cancer显示文摘 | Bareschino MA Schettino C Rossi A Maione P Sacco PC Zeppa R | 2011 | J Thorac Dis2011，3，2： | 1 |
| 13 | Structure and function of natural antibodies 显示文摘 | Casali P Schettino EW | 1996 | Curr Top Mierobiol lmmunol1996，210，： | 1 |
| 14 | Treatment of advanced non small cell lung cancer显示文摘 | Bareschino MA Schettino C Rossi A | 2012 | J Thorac Dis2012，3，2： | 1 |
| 15 | Evaluation of resistance in 8different heat-and-moisture exchangers Effects of saturation andflow rate/profile显示文摘 | Lucato JJ Tucci MR Schettino GP | 2005 | RespirCare2005，50，5： | 1 |
| 16 | Analyses ofspacer grids compression strength and fuel assemblies structural behavior显示文摘 | Schettino C F M Gouva J P Medeiros N | 2013 | Nuclear Engineering and Design2013，26，： | 1 |
| 17 | Inventive pro- ductivity and patent quality:evidence from Italian inventors显示文摘 | SCHETTINO F STERLACCHINI A VENTURINI F | 2013 | Journal of Policy Modeling2013，35，6： | 1 |
| 18 | Endoscopic endonasal approach to the pterygopalatine fossa: Anatomic study 显示文摘 | Alfieri A Jho HD Schettino R | 2003 | Neurosurgery2003，，52： | 1 |
| 19 | Erlotinib in cancer treatment显示文摘 | Bareschino MA Schettino C Troiani T | | 0，，6： | 1 |
| 20 | Persistent papillomavirus type-31and type-45infections predict the progression to squamous intraepithelial lesion显示文摘 | Schettino MT Ammaturo FP Grimaldi E | 2014 | Taiwan J Obstet Gynecol2014，53，4： | 1 |
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