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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence显示文摘BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related mortality.Classifying clinical parameters that increase risk for recurrence after IBTR remains a challenge.AIM To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease outcomes.METHODS Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our institution.Overall survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan Meier method.We identified patients who experienced an isolated IBTR.Concordance of hormone receptor status and location of tumor from primary to recurrence was evaluated.The effect of clinical and treatment parameters on disease outcomes was also evaluated.RESULTS We identified 2164 patients who met the eligibility criteria.The median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]years.Five-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 IBTRs.We identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ component.Median time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)years.Radiotherapy information was available for 30 of 37 patients.Median whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor bed.Twenty-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly associated.There were no observed changes in HER-2 status from primary to IBTR.The concordance between quadrant of primary to IBTR was 10/19[(62.2%),P=0.008].Tumor size greater than 1.5 cm(HR=0.44,95%CI:0.22-0.90,P=0.02)and use of endocrine therapy upfront(HR=0.36,95%CI:0.18-0.73,P=0.004)decreased the risk of IBTR.CONCLUSION Among patients with early stage breast cancer who had breast conserving surgery treated with adjuvant RT,ER/PR status and quadrant were highly concordant from primary to IBTR.Tumor size greater than 1.5 cm and use of adjuvant endocrine therapy were significantly associated with decreased risk of IBTR. | Juhi M Purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber | 2020 | World Journal of Clinical Oncology2020，11，1： | 2 |
| 3 | Heterotrimeric G proteins in heart disease显示文摘 | Schnabel P Bohm M | 1996 | Cell Signal1996，8，6： | 1 |
| 4 | Biomechanical comparison of a new staple technique with tension band wiring for transverse patella fractures显示文摘 | Schnabel B Scharf M Schwieger K | 2009 | Clin Biomech2009，24，10： | 1 |
| 5 | Ectopic expression of KitD814Y in spermatids of transgenic mice, interferes with sperm morphogenesis 显示文摘 | Schnabel D Ramirez L Gertsenstein M | 2005 | Dev Dyn2005，233，1： | 1 |
| 6 | A genome scan for quantitative trait loci influencing carcass,post-natal growth and reproductive traits in commercial Angus cattle显示文摘 | McClure M C Morsci N S Schnabel R D | 2010 | Anim Genet2010，41，6： | 1 |
| 7 | Lavage of contaminated surfaces: an in vitro evaluation of the effectiveness of different systems显示文摘 | Bahrs C Schnabel M Frank T | 2003 | J Surg Res2003，112，1： | 1 |
| 8 | Procalcitonin-influence of temperature,storage,anticoagulation and arterial or venous asservation of blood samples on procalcitonin concentrations显示文摘 | Meisner M Tschaikowsky K Schnabel S | | 0，，08： | 1 |
| 9 | Dedifferentiation --associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture 显示文摘 | Schnabel M Marlovits S Eckhoff G | 2002 | Os- teoarthritis and Cartilage2002，10，1： | 1 |
| 10 | Polyester- idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery 显示文摘 | BLAUDSZUN A R LIAN Q SCHNABEL M | 2014 | Int J Pharm2014，474，12： | 1 |
| 11 | Primary human herpesvirus 7 infection: a comparison of human herpesvirus 7 and human herpesvirus 6 infections in children显示文摘 | CASERTA M T HALL C B SCHNABEL K | 1998 | J Pediatr1998，133，3： | 1 |
| 12 | Monilinia species causing brown rot of peach in China显示文摘 | HU M COX K D SCHNABEL G | 2011 | Plo S One2011，6，24： | 1 |
| 13 | Differention- associated changes in morphology and gene expression in primary human articular chondrocytes in culture 显示文摘 | Schnabel M Marlovits S Echkhoff G | 2002 | Osteoarthritis Cartilage2002，10，1： | 1 |
| 14 | Differential expression of Notch genes in human osteoblastic cells显示文摘 | Schnabel M Fichtel I Gotzen L et ai | 2002 | Int JMol Med2002，9，3： | 1 |
| 15 | Solitary pulmonary nodules:MR evalution of enhancement patterns with contrast-enhanced dynamic snapshot gradient-echo imaging显示文摘 | Guckel C Schnabel K Deimling M | 1996 | Radiology1996，200，3： | 1 |
| 16 | The relationship of mammographic density and age: implications for breast cancer screening显示文摘 | Checka C M Chun J E Schnabel F R et al | 2012 | AJR2012，198，3： | 1 |
| 17 | Hyper or normobaric oxy- gen therapy to treat migraine and cluster headache pain 显示文摘 | Schnabel A Bennet M Schuster F | 2008 | schmerz2008，22，2： | 1 |
| 18 | Spatial and seasonal variation of gross nitrogen transformations and microbial biomass in a northeastern US grassland显示文摘 | Corre M D Schnabel R Stout | 2002 | Soil Biology & Biochemistry2002，34，： | 1 |
| 19 | Pathological changes of the myocardium in patients after artial repair for transposition of the great arteries:a possible explanation for left ventricular dysfuntion after secondary arterial switch显示文摘 | Gorenflo M Schnabel P A | 2003 | Z Kardiol2003，92，12： | 1 |
| 20 | Genome-wide association analysis for feed efficiency in Angus cattle 显示文摘 | Rolf M M Taylor J F Schnabel R D | 2012 | Anim Genet2012，43，4： | 1 |
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