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| 1 | 表面硬化钢的高温渗碳显示文摘1.导言表面硬化是一种改善零件性能,特别是交变负荷和磨损负荷下性能的重要工艺。因为表面硬化费用高,能耗大和时间长,所以一直在考虑提高工艺的经济性。首先是通过缩短处理时间达到提高经济性。除了使用目前流行的渗碳处理与直接淬火相结合外,只有通过提高渗碳温度才可能达到这一点。 2. | Scholer V. 景学庸 | 1991 | 国外金属热处理1991，12，1： | 3 |
| 2 | Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells显示文摘Embryonic stem cells(ESCs) maintain their cellular identity through the systematic regulation of master transcription factors and chromatin remodeling complexes. Recent work has shown that the unusually large-scale enhancers—namely super-enhancers(SEs), on which BRD4, a member of the bromodomain and extraterminal domain(BET) family is highly enriched—could regulate pluripotency-related transcription factors. Moreover, inhibition of BRD4 binding on SEs has been shown to induce the differentiation of ESCs. However, the underlying mechanism of BRD4 inhibition-mediated stem cell differentiation remains elusive. Here we show that both mouse and human ESCs lose their capacity for self-renewal upon treatment with JQ1, a selective inhibitor of BET family including BRD4, with rapid suppression of pluripotency-associated genes. Notably, a high concentration of JQ1 could selectively eliminate ESCs via apoptosis, without affecting the functionality of differentiated somatic cells from ESCs, suggesting that inhibition of BET may have a beneficial effect on the development of pluripotent stem cell-based cell therapy. | Jung Hyun Im Seon In Hwang Jong-Wan Kim soon-Jung Park Kyu-ree Kang Jueng Soo You Kee Pyo Kim Sung-Hwan Moon Hyuk-Jin Cha Hyung-Min Chung Hans R. Scholer Jung Keun Hyun DongWook Han | 2018 | Science Bulletin2018，63，8： | 2 |
| 3 | Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea显示文摘 | Mueller C Scholer A Laule-Kilian K | 2004 | N Engl J Med2004，350，7： | 1 |
| 4 | Fluorescence fingerprints Cu2+ and -complexmg ability of individual molecular size fractions in soil- and waste-borne DOM 显示文摘 | De Zarruk K K Scholer G Dudal Y | 2007 | Chemosphere2007，69，： | 1 |
| 5 | High prevalence of un-known co-medication in hospitalised patients显示文摘 | Rieger K Scholer A Amet I | 2004 | Eur JClin Pharmacol2004，60，5： | 1 |
| 6 | Serum mi-croRNAs as a novel class of biomarkers: A comprehensive review of the literature 显示文摘 | Scholer N Langer C Dohner H | 2010 | Experimental Hematology2010，38，12： | 1 |
| 7 | Mode of action of 5-fluorocytosine and mechanisms of resistance显示文摘 | SCHOLER H J | 1975 | Chemotherapy1975，21，： | 1 |
| 8 | The onset of germ cell migration in the mouse embryo 显示文摘 | Anderson R Copeland TK Scholer H | 2000 | Mech Dev2000，91，： | 1 |
| 9 | Fluorescence fingerprints and Cu2+-complexing ability of individual molecular size fractions in soil-and waste-borne DOM显示文摘 | DE ZARRUK K K SCHOLER G DUDAL Y | 2007 | Chemosphere2007，69，4： | 1 |
| 10 | Oct-4:gatekeeper in the beginnings of mammalian development显示文摘 | PESCE M SCHOLER HR | 2001 | Stem Cells2001，19，4： | 1 |
| 11 | Atovaquone nanosuspensions show excellent therapeutic effect in a new routine model of reactivated toxoplasmosis 显示文摘 | SCHOLER N KRAUSE K KAYSER O | 2001 | Antimicrob Agents Chemother2001，45，6： | 1 |
| 12 | Morbidity of prostatic biopsy for different biopsy strategies:is there a relation to core number and sampling region显示文摘 | Paul R Scholer S Randenborgh H van | | 0，，： | 1 |
| 13 | CELIAS - Charge, Element and Isotope Analysis System for SOHO显示文摘 | D. Hovestadt M. Hilchenbach A. Bürgi B. Klecker P. Laeverenz M. Scholer H. Grünwaldt W. I. Axford S. Livi E. Marsch B. Wilken H. P. Winterhoff F. M. Ipavich P. Bedini M. A. Coplan A. B. Galvin G. Gloeckler P. Bochsler H. Balsiger J. Fischer J. Geiss R. Ka | 1995 | Solar Physics (-)1995，，1： | 1 |
| 14 | Octamania: the POU factors in murine development 显示文摘 | Scholer HR | 1991 | Trends Genet1991，7，10： | 1 |
| 15 | Prevalence and frequency of circulating t(14; 18)-MBR translocation carrying cells in healthy individuals显示文摘 | SCHOLER F DOLKEN L HIRT C | 2009 | IntJ Cancer2009，124，4： | 1 |
| 16 | Drug interference in clinical chemistry:recommendation of drugs and their concentrations to be used in drug interference studies显示文摘 | Sonntag O Scholer A | 2001 | Clin Biochem2001，38，4： | 1 |
| 17 | Derivation of oocytes from mouse embryonic stem cells显示文摘 | Hubner K Fuhrmann G Scholer HR | 2003 | Science2003，300，： | 1 |
| 18 | A family of octamer-specific proteins present during mouse embryogenesis:evidence for germline-specific expression of an OCT factor显示文摘 | Scholer HR Hatzopoulos AK Balling R | 1989 | EMBO J1989，8，9： | 1 |
| 19 | Oct-4:Gatekeeper in the beginnings of mammalian development显示文摘 | Pesce M Scholer HR | 2001 | Stem Cells2001，19，4： | 1 |
| 20 | Use of Btype patriuretic peptide in the evaluation and management of acute dyapne4显示文摘 | Mueller C Scholer A Laule-Kilian K | 2004 | N Engl1 Med2004，350，7： | 1 |
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