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| 1 | Effects of retinoic acid on proliferation,phenotype and expression of cyclin-dependent kinase inhibitors in TGF-β1-stimulated rat hepatic stellate cells显示文摘AIM To study the molecular mechanisms ofretinoic acid(RA)on proliferation andexpression of cyclin-dependent kinase inhibitors(CKI),i.e.p16,p21 and p27 in cultured rathepatic stellate cells(HSC)stimulated withtransforming growth factor beta 1(TGF-β1).METHODS HSC were isolated from healthy ratlivers and cultured.After stimulated with1 mg/L TGF-β1,subcultured HSC were treatedwith or without 1 nmol/L RA.MTT assay,immunocytochemistry(ICC)for p16,p21,p27and α-smooth muscle actin(α-SMA)protein,insitu hybridization(ISH)for retinoic acidreceptor beta 2(RAR-β2)and p16,p21 and p27mRNA and quantitative image analysis(partially)were performed.RESULTS RA inhibited HSC proliferation(41.50%,P<0.05),decreased the protein levelof α-SMA(55.09%,P<0.05),and induced HSCto express RAR-β2 mRNA.In addition,RAincreased the protein level of p16(218.75%,P<0.05)and induced p21 protein expression;meanwhile,p27 was undetectable by ICC in bothcontrol and RA-treated HSC.However,RA hadno influence on the mRNA levels of p16,p21 orp27 as determined by ISH.CONCLISION Up-regulation of p16 and p21 on post-transcriptional level may contribule, in part to RA inhibition of TGF-β1-initiated rat HSC activation in vitro. | Guang Cun Huang Jin Sheng Zhang Yue E Zhang Department of Pathology School of Basic Medical Sciences,Fudan University.Shanghai 200032,China | 2000 | World Journal of Gastroenterology2000，6，6： | 23 |
| 2 | The common language of space:a way of looking at the social,economic and environmental functioning of cities on a common basis显示文摘This paper proposes that in addition to urban research which seeks to provide answers to policy questions, there is also a need for research which directly addresses the physical and spatial complexity of the built environment itself, and explores any effects it may in itself have on the functioning of the urban system. This type of research reflects the questions architects and urban designers typically ask, rather than those that preoccupy planners. For such research to be effective, the physical complexity variable must be controlled at the level at which real design decisions are made. “Space syntax” research attempts to do this by treating built environments as systems of space, analysing them “configurationally”, and trying to bring to light their underlying patterns and structures. Results from space syntax research into many aspects of urban space and how it works show a consistency which suggests that analysing spacial structure can be a general means of investigating the structure and function of cities. It may, in effect, be the common language of the city. | Bill Hillier Bartlett School of Graduate Studies, University College London, Gower Street, London WC1E 6BT, U.K. E\|mail:b.hillier@ucl.ac.uk | 1999 | Journal of Environmental Sciences1999，11，3： | 18 |
| 3 | Quantum phase transition and entanglement in Li atom system显示文摘By use of the exact diagonalization method, the quantum phase transition and en- tanglement in a 6-Li atom system are studied. It is found that entanglement appears before the quantum phase transition and disappears after it in this exactly solvable quantum system. The present results show that the von Neumann entropy, as a measure of entanglement, may reveal the quantum phase transition in this model. | SI LiMing1 & HOU JiXuan2 1 Department of Electronic Engineering, School of Information Science and Technology, Beijing Institute of Technology, Beijing 100081, China 2 Laboratoire de Chimie, UMR 5182 CNRS, Ecole Normale Supérieure de Lyon, 46, Allée d’Italie, F-69364 Lyon Cedex 07, France | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 6 |
| 4 | Landscape ecological characteristics in temporal changes of riverside open space in urbanized area显示文摘1IntroductionRecentlyinJapan,theriverspaceinurbanareasischangingintoriverparks,riveropenspaceandnatureorientedbank.Consequen... | Shigeru TANIMOTO *, Nobukazu NAKAGOSHI Graduate School for International Development and Cooperation, Hiroshima University, Kagamiyama, Higashi Hiroshima 739 8529, Japan. E mail: shigeru.tanimoto@aratani.co.jp | 1999 | Journal of Environmental Sciences1999，11，2： | 3 |
| 5 | A review of the most im- portant classes of serine protease inhibitors in insects and leeches显示文摘 | Clynen E Schools L Salzet M | 2005 | Medicinal Chemistry Reviews2005，2，3： | 1 |
| 6 | SAW-based radio sensor sys- tems for short-range applications 显示文摘 | School G Korden C Riha E | 2003 | IEEE Microwave Magazine2003，4，4： | 1 |
| 7 | Simulation of decoking of thermal cracking coils by steam/air mixtures 显示文摘 | School E M Froment G F | 1997 | AIChE J1997，43，1： | 1 |
| 8 | Aerosolized perfluoroearbon suppresses early pulmonary inflammatory response in a surfactant-depleted piglet model显示文摘 | von der Hardt K School E Kandler M A | 2002 | Pediatr Res2002，51，2： | 1 |
| 9 | Coke Com- bustion and Gasification Kinetics in Ethane Steam Crackers 显示文摘 | Heynderickx G J Schools E M Marin G B | 1995 | AIChE J1995，51，5： | 1 |
| 10 | Simulation of the Decoking of an Ethane Cracker with a Steam/Air Mixture 显示文摘 | Heynderickx G J Schools E M Marin G B | 2006 | Chemical Engineering Science2006，61，6： | 1 |
| 11 | The Application of the Edge Sharpening Operator to the Breast Near-Infrared Imaging显示文摘The principles of Gradient operator, Laplacian operator, LOG operator and Sobel operator are discussed. Certain features of breast can be extracted in different degrees and aspects from original images by applying four edge sharpening operators to the breast near infrared imaging. A great number of cases prove that compared with the other three operators, the improved Sobel operator can effectively extract the structural features of the breast from an original image. It can be concluded that the improved Sobel operator can assist in diagnosing breast diseases. | Xiang Yan 1 , Li Kai yang 1 , Yang Xuan dong 1 , Wang Xiao fang 2 ,Zhang Xian lin 2 ,Zhu Yi jun 3 1. School of Physics and Technology, Wuhan University, Wuhan 430072, Hubei, China 2. Tumor Research Institute of Hubei Province, Wuhan 430079,Hubei, China 3. E Sea Digital Engineering Limited Company, Wuhan 430072, Hubei, China | 2002 | Wuhan University Journal of Natural Sciences2002，7，4： | 1 |
| 12 | Comparison of renal morphology in the Streptozotocin and the SHR/N-cp models of diabetes 显示文摘 | Gross ML Ritz E School A | 2004 | Lab Invest2004，84，： | 1 |
| 13 | Origins of aberrant DNA methylation in acute myeloid leukemia 显示文摘 | Schools T Berdel W E Mtiller-Tidow C | 2014 | Leukemia2014，28，1： | 1 |
| 14 | Malignant fibrous histiccytoma of the pulmonary artery显示文摘 | Van Damme H Vaneerdeweg W Schools E | 1987 | Annals of Surgery1987，205，2： | 1 |
| 15 | Simulation of decoking of thermal cracking coils by steam/air mixtures显示文摘 | School E M Froment G F | 1997 | AIChE J1997，43，1： | 1 |
| 16 | National innovative capacity 显示文摘 | PORTER M E SCHOOL H B | 2001 | Global Competitiveness Report2001，31，6： | 1 |
| 17 | Preseason heat-acclimatization guidelinesfor secondary school athletics显示文摘 | Casa D J Csillan D Inter-Association Task Force for PreseasonSecondary School Athletics Participants Armstrong L E Baker LB Bergeron M F | 2009 | J Athletic Train2009，44，： | 1 |
| 18 | Laser collimation of a chromium beam显示文摘 | School R E Gupte R McClelland J J | 1997 | Phys Rev A1997，55，2： | 1 |
| 19 | MicroRNAs in cancer treatment and prognosis显示文摘 | School C R Botelho E L Izzotti A | 2012 | American Journal of Cancer Research2012，2，： | 1 |
| 20 | Coke Combustion and Gasification Kinetics in Ethane Steam Crackers 显示文摘 | Heynderickx G J Schools E M Marin G B | 2005 | AIChE Journal (S1547-5905)2005，51，5： | 1 |
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