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| 1 | Asthma and metabolic syndrome: Current knowledge and future perspectives显示文摘Asthma and obesity are epidemiologically linked; however, similar relationships are also observed with other markers of the metabolic syndrome, such as insulin resistance and dyslipidemia, which cannot be accounted for by increased body mass alone. Obesity appears to be a predisposing factor for the asthma onset, both in adults and in children. In addition, obesity could make asthma more difficult to control and to treat. Although obesity may predispose to increased Th2 inflammation or tendency to atopy, othermechanisms need to be considered, such as those mediated by hyperglycaemia, hyperinsulinemia and dyslipidemia in the context of metabolic syndrome. The mechanisms underlying the association between asthma and metabolic syndrome are yet to be determined. In the past, these two conditions were believed to occur in the same individual without any pathogenetic link. However, the improvement in asthma symptoms following weight reduction indicates a causal relationship. The interplay between these two diseases is probably due to a bidirectional interaction. The purpose of this review is to describe the current knowledge about the possible link between metabolic syndrome and asthma, and explore potential application for future studies and strategic approaches. | Laura Serafino-Agrusa Mario Spatafora Nicola Scichilone | 2015 | World Journal of Clinical Cases2015，3，3： | 4 |
| 2 | The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly显示文摘 | Amir A. Zeki Michael Schivo Andrew Chan Timothy E. Albertson Samuel Louie Nicola Scichilone | 2011 | Journal of Allergy2011，，： | 2 |
| 3 | Rapidly progressive or- ganising pneumonia associated with cytomegalovirus infection in a patient with psoriasis 显示文摘 | Messina M Scichilone N Guddo F | 2007 | Monaldi Arch Chest Dis2007，67，3： | 1 |
| 4 | Biomarkers in obstructive respiratory diseases: an update显示文摘 | Braido F Bagnasco D Scichilone N | 2012 | Panminerva Med2012，54，2： | 1 |
| 5 | Diagnosis and managementof asthma in the elderly显示文摘 | Scichilone N Pedone C Battaglia S | 2014 | E ut J Intern Med2014，25，4： | 1 |
| 6 | Clinieal implications of airway hyper-responsiveness in COPD 显示文摘 | SCICHILONE N BATTAGLIA S LA SALA A | 2006 | Int J Chron Obstruct Pulmon Dis2006，1，1： | 1 |
| 7 | Biomarkers in obstructive respiratory diseases:an update显示文摘 | Braido F Bagnasco D Scichilone N | | 0，，02： | 1 |
| 8 | The mini nutritional assessment is associated with the perception of dyspnoea in older subjects with advanced COPD显示文摘 | SCICHILONE N PAGLINO G BATFAGLIA S | 2008 | Age Ageing2008，37，2： | 1 |
| 9 | The effect of intranasal corticosteroids on asthma control and quality of Life in allergic rhinitis with mild asthma显示文摘 | Scichilone N Arrigo R Paternò A | | 0，，： | 1 |
| 10 | The role of smallairways in monitoring the response to asthma treatment : what isbeyond FEVJ 显示文摘 | Scichilone N Battaglia S Olivieri D | 2009 | Allergy2009，64，11： | 1 |
| 11 | Clinical impli- cations of airway hyperresponsiveness in COPD 显示文摘 | Scichilone N Battaglia S La Sala A | 2006 | Int J Chron Obstruct Pulmon Dis2006，1，1： | 1 |
| 12 | Allergen sensitiza- tions in southern Italy: a 5-year retrospective study in allergic respiratory patients显示文摘 | Scichilone N Sanfilippo A Sorino C et a l | 2013 | Eur Ann Allergy Clin Immunol2013，45，3： | 1 |
| 13 | The effect of intranasal corticosteroids on asthma control and quality of life in allergic rhinitis with mild asthma显示文摘 | Scichilone N Arrigo R PaternòA | 2011 | J Asthma2011，48，1： | 1 |
| 14 | Impact of extrafineformulations of inhaled corticosteroids/lang-acting beta-2 agonist combinations on patient-related outcomes in asthma and COPD 显示文摘 | Scichilone N Benfante A Morandi L | 2014 | Patient Relat Outcome Meas2014，5，15： | 1 |
| 15 | The lack of the broncho- protective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness 显示文摘 | Scichilone N Permutt S Togias A | 2001 | Am J RespirCrit Care Med2001，163，2： | 1 |
| 16 | Clinical implications of airway hyperresponsiveness in COPD显示文摘 | Scichilone N Battaglia S La Sala A | 2006 | Int J Chron Obstruct Pulmon Dis2006，1，1： | 1 |
| 17 | High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma显示文摘 | Brown RH Scichilone N Mudge B | 2001 | Am J Respir Crit Care Med2001，163，4： | 1 |
| 18 | Effects of extra-fineinhaled beclomethasone/formoterol on both large and smallairways in asthma 显示文摘 | Scichilone N Battaglia S Sorino C | 2010 | Allergy2010，65，7： | 1 |
| 19 | The mini nutritional assessment isassociated with the percep- tion of dyspnoeain older subjects with advanced COPD显示文摘 | Nicola Scichilone Giuseppe Paglino Salvatore Battaglia | 2008 | Age and Ageing2008，37，： | 1 |
| 20 | Effects of extra-fineinhaled beclomethasone/formoteral on both large and smallairways in asthma 显示文摘 | Scichilone N Battaglia S Sorino C | 2010 | Allergy2010，65，10： | 1 |
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