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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Marked improvement of PAC and BAG cloning is achieved using electroelution of pulsed-field gelseperated partial digested of genomic DNA显示文摘 | Scott J S Yuko O Gary W L | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 3 | Stem-like cells in bone sarcomas: implications for tumorigenesis显示文摘 | Gibbs C P Kukekov V G Reith J D Tchigrinova O Suslov O N Scott E W | 2005 | Neoplasia2005，7，： | 1 |
| 4 | Detection of Apple chlorotic leaf spot and Apple stem grooving viruses using RT-PCR显示文摘 | Kinard G R Scott S W Barnett O W | 1996 | Plant Disease1996，80，： | 1 |
| 5 | Synthesis,characterization,and applications of en drimer-encapsulated nanoparticles 显示文摘 | Scott r W J Wilson O M CrookS R M | 2005 | Journal of Physical Chemistry B2005，109，2： | 1 |
| 6 | A Review of Empirical Research on Manufacture Flexibility显示文摘 | Scott W o'Leary-kelly | 2000 | Journal of operations Management 182000，，： | 1 |
| 7 | Bimetallic palladium-gold dendrimer encapsulated catalysts显示文摘 | SCOTT R W J WILSON O M OH S K | 2004 | J Am Chem Soc2004，126，15： | 1 |
| 8 | Marked improved of PAC and BAC cloning is achieved using electroelution of pulsed-field gel separated partial digest of genomic DNA显示文摘 | Scott J Yuko O Gary W | 1997 | Nucleic Acids Res1997，25，19： | 1 |
| 9 | Synthesis, Characterization, and Applications of Dendrimer-Encapsulated Nanoparticles显示文摘 | Scott R W J Wilson O M Crooks R M | 2005 | J Phys Chem B2005，109，2： | 1 |
| 10 | Macular hole surgery with internal-limiting membrane peeling and intravitreous air显示文摘 | Donald W Park Jack O Sipperley Scott R Sneed Pravin U Dugel Jaclin Jacobsen | 1999 | Ophthalmology1999，，7： | 1 |
| 11 | 显示文摘 | O G Bentley H W Scott | 1959 | J Dairy Sci1959，42，： | 1 |
| 12 | Olfactory marker protein(OMP) gene deletion causes altered physiological activity of olfactory sensory neurons显示文摘 | BUIAKOVA O I BAKER H SCOTT J W | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 13 | Synthesis,Characterization,and Applications of Dendrimer-Encapsulated Nanoparticles显示文摘 | SCOTT R W J WILSON O M CROOKS R M | | 0，，02： | 1 |
| 14 | Synthesis,Characterization,and Structure-Selective Extraction of 1-3-nm Diameter AuAg Dendrimer-Encapsulated Bimetallic Nanoparticles显示文摘 | WILSON O M SCOTT R W J GARCIA-MARTINEZ J C | | 0，，03： | 1 |
| 15 | Detection of apple chlorofic leaf spot and apple stem grooving viruses using RT-PCR显示文摘 | KINARD G R SCOTT S W BARNETT O W | 1996 | Plant Disease1996，80，6： | 1 |
| 16 | Synthesis,characterization,and applications of dendrimer-encapsulated nanoparticles显示文摘 | SCOTT R W J WILSON O M CROOKS R M | 2005 | J Phys Chem B2005，109，2： | 1 |
| 17 | Quality of life,morbidity,and mortality after low trauma hip fracture in men显示文摘 | Pande I Scott D L O′Neill T W | 2006 | Ann Rheum Dis2006，65，1： | 1 |
| 18 | Time Domain Reflectometry Mesurement Principle and Applications 显示文摘 | Scott B J Jon M W Dani O | 2002 | Hydrol Process2002，16，： | 1 |
| 19 | Primary bilateral parenchymal renal aspergillus infection显示文摘 | Scott W Lisson Walter C Hellinger Raul O Parra | 2002 | Urology2002，，2： | 1 |
| 20 | The empirical assessment of construct validity显示文摘 | O'Leary-Kelly Scott W Vokurka Robert J | 1998 | Journal of Operations Management1998，16，： | 1 |
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