|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The ameliorating effects of stigmasterol on scopolamine-induced memory impairments in mice显示文摘 | Se Jin Park Dong Hyun Kim Jun Man Jung Jong Min Kim Mudan Cai Xiaotong Liu Jin Gyu Hong Chang Hwan Lee Kang Ro Lee Jong Hoon Ryu | 2011 | European Journal of Pharmacology2011，，1： | 1 |
| 2 | Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts显示文摘 | Jeong Kyun Seo Su Hyun Kim Sang Hyub Lee Joo Kyung Park Sang Myung Woo Ji Bong Jeong Jin-Hyeok Hwang Ji Kon Ryu Jin-Wook Kim Sook-Hyang Jeong Yong-Tae Kim Yong Bum Yoon Kuhn Uk Lee Se Hyung Kim Min A. Kim | 2010 | European Journal of Gastroenterology & Hepatology2010，，8： | 1 |
| 3 | The neuroprotective effects of the seeds of Cassia obtusifolia on transient cerebral global ischemia in mice显示文摘 | Dong Hyun Kim Sunho Kim Won Yong Jung Se Jin Park Dong Hyun Park Jong Min Kim Jae Hoon Cheong Jong Hoon Ryu | 2009 | Food and Chemical Toxicology2009，，7： | 1 |
| 4 | Transmesocolic hernia with strangulation in a patient without surgical history: Case report显示文摘Transmesenteric hernias have bimodal distribution and occur in both pediatric and adult patients. In the adult population, the cause is iatrogenic, traumatic, or inflammatory. We report a case of transmesocolic hernia in an elderly person without any preoperative history. An 84-year-old Korean female was admitted with midabdominal pain and distension for 1 d. On abdominal computed tomography, we diagnosed transmesocolic hernia with strangulated small bowel obstruction, and performed emergency surgery. The postoperative period was uneventful and she was discharged 11 d after surgery. Hence, it is important to consider the possibility of transmesocolic hernia in elderly patients with signs and symptoms of intestinal obstruction, even in cases with no previous surgery. 2013 Baishideng. All rights reserved. | Peel Jung Min Dae Kim Tae Hyun Ryu Sung Ho Choi Han Se Kim Kang Hun Lee Jhong Hyun Park | 2013 | World Journal of Gastroenterology2013，19，12： | 1 |
| 5 | The neuroprotective effects of the seeds of Cassia obtusifolia on transient cerebral global ischemia in mice显示文摘 | Dong Hyun Kim Sunho Kim Won Yong Jung Se Jin Park Dong Hyun Park Jong Min Kim Jae Hoon Cheong Jong Hoon Ryu | 2009 | Food and Chemical Toxicology2009，，7： | 1 |
| 6 | Protriptyline,a tricyclic antidepressant,inhibits voltage-dependent K+channels in rabbit coronary arterial smooth muscle cells显示文摘In this study,we explore the inhibitory effects of protriptyline,a tricyclic antidepressant drug,on voltage-dependent K+(Kv)channels of rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique,Protriptyline inhibited the vascular Kv current in a concentrationdependent manner,with an IC5o value of 5.05±0.97μM and a Hill coefficient of 0.73+0.04.Protriptyline did not affect the steady-state activation kinetics.However,the drug shifted the steadystate inactivation curve to the left,suggesting that protriptyline inhibited the Kv channels by changing their voltage sensitivity.Application of 20 repetitive train pulses(1 or 2 Hz)progressively increased the protriptyline-induced inhibition of the Kv current,suggesting that protriptyline inhibited Kv channels in a use(state)-dependent manner.The extent of Kv current inhibition by protriptyline was similar during the first,second,and third step pulses.These results suggest that protriptyline-induced inhibition of the Kv current mainly occurs principally in the closed state.The increase in the inactivation recovery time constant in the presence of protriptyline also supported use(state)-dependent inhibition of Kv channels by the drug.In the presence of the Kv1.5 inhibitor,protriptyline did not induce further inhibition of the Kv channels.However,pretreatment with a Kv2.1 or Kv7 inhibitor induced further inhibition of Kv current to a similar extent to that observed with protriptyiine alone.Thus,we conclude that protriptyline inhibits the vascular Kv channels in a concentration-and use-dependent manner by changing their gating properties.Furthermore,protriptyline-induced inhibition of Kv channels mainly involves the Kv1.5. | Jin Ryeol An Hojung Kang Hongliang Li Mi Seon Seo Hee Seok Jung Won-Kyo Jung II-Whan Choi Sook Won Ryu Hongzoo Park Young Min Bae Se Min Ryu Won Sun Park | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 0 |
| 7 | Oncologic efficacy of gonadotropin-releasing hormone agonist in hormone receptor-positive very young breast cancer patients treated with neoadjuvant chemotherapy显示文摘BACKGROUND Breast cancer in young women has been shown to have an aggressive behavior and poor prognosis.AIM To evaluate the outcomes of young hormone receptor(HR)-positive patients with breast cancer treated with neoadjuvant chemotherapy(NAC),and the oncologic efficacy of gonadotropin-releasing hormone(GnRH)agonists.METHODS This retrospective study involved a prospectively enrolled cohort.We included patients diagnosed with invasive breast cancer who were treated with NAC followed by curative surgery at the Samsung Medical Center and Samsung Changwon Hospital between January 2006 and December 2017.Among patients with HR-positive and human epidermal grow factor 2(HER2)-negative breast cancer,we analyzed the characteristics and oncology outcomes between the patients equal to or younger than 35 years and the patients older than 35 years.RESULTS Among 431 patients with NAC and HR-positive/HER2-negative breast cancer,78 were 35 years old or younger,and 353 patients were older than 35 years.The median follow-up was 71.0 months.There was no statistically significant difference in disease free survival(DFS,P=0.565)and overall survival(P=0.820)between the patients equal to or younger than 35 years and the patients older than 35 years.The two groups differed in that the GnRH agonist was used more frequently in the group of patients equal to or younger than 35 years than in the other group(52.4%vs 11.2%,P<0.001).Interestingly,for the DFS according to the GnRH agonist in the group of patients equal to or younger than 35 years,patients treated with the GnRH agonist had better DFS(P=0.037).CONCLUSION Administration of GnRH agonists might improve the DFS rate of HR-positive/HER2-negative breast cancer in the equal to or younger than 35 years group of patients with NAC. | Hee Jun Choi Jun Ho Lee Chang Shin Jung Jai Min Ryu Byung Joo Chae Se Kyung Lee Jong Han Yu Seok Won Kim Seok Jin Nam Jeong Eon Lee Youn Joo Jung Hyun Yul Kim | 2023 | World Journal of Clinical Cases2023，11，27： | 0 |
| 8 | Hidradenocarcinoma of the Dorsum of the Hand显示文摘 | Wan Cheol Ryu Yong Hae Lee In Chang Koh Jang Sihn Sohn Se Min Jang | 2017 | Chinese Medical Journal2017，，14： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员