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| 1 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 2 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 3 | Use of small suture anchors in cervical laminoplasty to maintain canal expansion: a technical note 显示文摘 | Lee JY Hanks SE Oxner W | 2007 | J Spinal Disord Tech2007，20，1： | 1 |
| 4 | A comparison of ePTFE membranes alone or in combination with platelet-derived growth factors and insulin-like growth factors-I or demineralized freezedried bone in promoting bone formation around immediate extraction socket implants显示文摘 | Lynch SE Lekholm U | 1992 | J Periodontal1992，63，： | 1 |
| 5 | Olfactory identification deficits in schizophrenia:correlation with duration of illness显示文摘 | Moberg P J Doty RL Turetsky BI Arnold SE Mahr RN Gur RC Bilker W Gur RE | | 0，，7： | 1 |
| 6 | Use of small suture anchors incervicallaminoplastytomaintaincanalexpansion:a technical note显示文摘 | Lee JY Hanks SE Oxner W | 2007 | J Spinal Disord Tech2007，20，1： | 1 |
| 7 | The RAGE axis in early diabetic retinopathy显示文摘 | Barile GR Pachydaki SI Tari SR Lee SE Donmoyer CM Ma W | 2005 | Invest Ophthalm ol Vis Sci2005，46，8： | 1 |
| 8 | Trefftz methods for plane piezoelectricity显示文摘 | Se K Y Jin W G Sheng N | 2003 | Computer Assisted Mechanics and Engineering Science2003，10，： | 1 |
| 9 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 10 | Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression显示文摘 | Zhang W Feng JQ Harris SE | 2002 | Transgenic Res2002，10，5： | 1 |
| 11 | Caveolin-1/3 doubleknockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype显示文摘 | Park DS Woodman SE Schubert W | 2002 | Am J Pathol2002，160，6： | 1 |
| 12 | Use of small suture anchors in cervical laminoplasty to maintain canal expansion:a technical note 显示文摘 | Lee JY Hanks SE Oxner W | 2007 | J Spinal Disord Tech2007，20，1： | 1 |
| 13 | Numerical predictions of flow structure and local Nusselt number ratios along and above dimpled surfaces with different dimple depths in a channel显示文摘 | Se Y W Ligrani P M | 2004 | Numerical Heat Transfer:Part A2004，46，5： | 1 |
| 14 | Minimally invasive operation for breast cancer 显示文摘 | Singletary SE Dowlatshahi K Deoley W | 2004 | Curr Probl Surg2004，41，4： | 1 |
| 15 | Prognostic significance of occult lymph node metastases in node-negative breast cancer显示文摘 | Sener SF Wilkens W | 1997 | Ann Surg Oncol1997，4，6： | 1 |
| 16 | Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib显示文摘 | W J Lee J L Lee SE Chang | 2009 | British Journal of Dermatology2009，161，： | 1 |
| 17 | Outcome at age 4 years in offspring of woman with maternal PKU: The maternal PKU collaborative study 显示文摘 | Waisbren SE Hanley W Levy HL | 2000 | JAMA2000，283，6： | 1 |
| 18 | Light-weight RFID device interface for controlling RFID tag memory access显示文摘 | Se W O Bang H Hwang J G | 2010 | ICACT Feb2010，，710： | 1 |
| 19 | Nit ric oxide synthase and nitrite production in human spermatozoa:evidence that end ogenous nitric oxide is beneficial to sperm motility显示文摘 | Lewis SE Donnelly ET sterling ES kennedy MS Thompson W & Chakravarthy U | 1996 | Mol Hum Reprod1996，2，11： | 1 |
| 20 | Comparison of systemic adverse events associated with intravitreal anti-VEGF injection: Ranibi- zumab versus Bevacizumab显示文摘 | Duck H Yong K Se W | 2012 | Korean Med Sci2012，27，12： | 1 |
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