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您的检索式：作者名="Seahyoung Lee"
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| 1 | Impact of miRNAs on cardiovascular aging显示文摘老化是导致得严重疾病的增加的风险的一个多维的过程,例如癌症并且心血管, neurodegenerative,和免疫学的疾病。最近,作为 microRNAs (miRNAs ) 知道的小非编码的 RNA 被显示了调整基因表示,它在人贡献生理的许多和 pathophysiological 过程。增加的证据建议在 miRNA 表示侧面的变化贡献细胞的老朽,老化和老化相关的疾病。然而,仅仅其功能被阐明了的一些 miRNAs 与老化或老化相关的疾病被联系了。这篇文章关于老化相关的 miRNAs 的角色考察当前可得到的调查结果,与心脏、心血管的老化的一个焦点。 | Seahyoung Lee Eunhyun Choi Min-Ji Cha Ae-Jun Park Cheesoon Yoon Ki-Chul Hwang | 2015 | Journal of Geriatric Cardiology2015，12，5： | 6 |
| 2 | Micro RNAs as mediators of cardiovascular disease: Targets to be manipulated显示文摘Cardiovascular disease has been the leading cause of death worldwide for the last few decades. Even with therapid progression of the biomedical field, conquering/managing cardiovascular disease is not an easy task because it is multifactorial disease. One of the key players of the development and progression of numerous diseases is micro RNA(mi RNA). These small, non-coding RNAs bind to target m RNAs to inhibit translations of and/or degrade the target m RNAs, thus acting as negative regulators of gene expressions. Accumulating evidence indicates that non-physiological expressions of mi RNAs contribute to both development and progression of cardiovascular diseases. Since even a single mi RNA can have multiple targets, dysregulation of mi RNAs can lead to catastrophic changes of proteins that may be important for maintaining physiologic conditions of cells, tissues, and organs. Current knowledge on the role of mi RNAs in cardiovascular disease is mostly based on the observational data such as microarray of mi RNAs in animal disease models, thus relatively lacking insight of how such dysregulation of mi RNAs is initiated and regulated. Consequently, future research should aim to elucidate the more comprehensive mechanisms of mi RNA dysregulation during pathogenesis of the cardiovascular system so that appropriate countermeasures to prevent/manage cardiovascular disease can be developed. | Seahyoung Lee Eunhyun Choi Sung-Man Kim Ki-Chul Hwang | 2015 | World Journal of Biological Chemistry2015，6，2： | 1 |
| 3 | Microenvironmental regulation of stem cells injected in the area at risk of neurodegenerative diseases显示文摘The complex mechanism of degenerative diseases and the non-specific modulation of regenerative targets aretopics that need to be elucidated in order to advance the use of stem cells in improvement of neurodegenerative diseases.From pre-transplantation through post-transplantation, there are many changes in the conditions, both inside andoutside of the stem cells that have not been carefully considered. This has hindered development in the field of celltherapy and regeneration. This viewpoint highlights the potential implications of intracellular and extracellularalterations of stem cells in transplanted areas at risk of neurodegenerative disease. | JU HYUNG LEE IL-KWON KIM SANG WOO KIM SOYEON LIM SEAHYOUNG LEE KI-CHUL HWANG BYEONG-WOOK SONG | 2022 | BIOCELL2022，46，10： | 0 |
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