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您的检索式：作者名="Sebastian Preissl"
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| 1 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 2 | Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain显示文摘Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions in mammals;however,the specific cell types and gene loci affected by this type of epigenetic change have remained unclear.To address this knowledge gap,we probed chromatin accessibility at single-cell resolution in the brains,hearts,skeletal muscles,and bone marrows from young,middle-aged,and old mice,and assessed age-associated changes at 353,126 candidate cis-regulatory elements(cCREs)across 32 major cell types.Unexpectedly,we detected increased chromatin accessibility within specific heterochromatin domains in old mouse excitatory neurons.The gain of chromatin accessibility at these genomic loci was accompanied by the cell-type-specific loss of heterochromatin and activation of LINE1 elements.Immunostaining further confirmed the loss of the heterochromatin mark H3K9me3 in the excitatory neurons but not in inhibitory neurons or glial cells.Our results reveal the cell-type-specific changes in chromatin landscapes in old mice and shed light on the scope of heterochromatin loss in mammalian aging. | Yanxiao Zhang Maria Luisa Amaral Chenxu Zhu Steven Francis Grieco Xiaomeng Hou Lin Lin Justin Buchanan Liqi Tong Sebastian Preissl Xiangmin Xu Bing Ren | 2022 | Cell Research2022，32，11： | 0 |
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