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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Neuronal Histamine Regulates Food Intake,Adiposity,and Uncoupling Protein Expression in Agouti Yellow (Ay/a) Obese显示文摘 | Seiichi C GO Y | 2003 | Mice Endocrinology2003，144，6： | 1 |
| 3 | Central Infusion of Histamine Reduces Fat Accumulation and upregulates UCP Family in Leptin-Resistant Obese Mice显示文摘 | Hironobu Y Seiichi C | 2001 | Diabetes2001，50，2： | 1 |
| 4 | Performance and emission characteristics of a diesel engine fueled with coconut oil diesel fuel blend 显示文摘 | Herchel T C Machacon Shiga Seiichi | 2001 | Biomass and Bioenergy2001，20，： | 1 |
| 5 | Lens design: Global Optimization of both Performance and Tolerance Sensitivity 显示文摘 | Isshiki Masaki Sinclair Douglas C Kaneko Seiichi | 2006 | Proceedings of the SPIE(S0277-786X)2006，6342，63： | 1 |
| 6 | An E2F1-dependent gene expression program that determines the balance between proliferation and cell death显示文摘 | Timothy C Hallstrom Seiichi Mori R | 2008 | Cancer Cell2008，13，1： | 1 |
| 7 | Performance and emission characteristics of diesel engine fueled with coconut oil-diesel fuel blend显示文摘 | Herchel T C Machacon Seiichi Shiga | 2001 | Biomass Bioenergy2001，20，1： | 1 |
| 8 | Disturbance observer and feedforward design for a high-peed direct-drive positioning table 显示文摘 | Kempf C J Seiichi Kobayashi | 1999 | IEEE Transactions on Control System Technology1999，7，5： | 1 |
| 9 | Histidine Suppresses Food Intake through Its Conversion into Neuronal Histamine显示文摘 | Seiichi C Daisuki T | 2002 | ExpBiolMed2002，227，1： | 1 |
| 10 | L-Histidine stimulates sympathetic nerve activity to brown adipose tissue in rats显示文摘 | Takayuki M Seiichi C | 2004 | Neuroscience Letters2004，362，2： | 1 |
| 11 | Involvement of hypothalamic Histamine H1 Receptor in yhe Regulation of Feeding Rhythm and Obesity显示文摘 | Seiichi C Tohru Y | 2004 | Diabetes2004，53，9： | 1 |
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