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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Ocular optical aberrations after photorefractive keratectomy for myopia and myopic astigmatism显示文摘 | Seiler T Kaemmerer M Mierdel P | 2000 | Arch Ophthalmol2000，118，1： | 1 |
| 3 | Evaluation of Posttraurnatic cerebral blood flow velocities by transcranial Doppler ultrsaona graphy显示文摘 | Weber M Grolinund P Seiler RW | 2001 | Neurosurgery2001，27，： | 1 |
| 4 | Mesh stability of look-ahead inter connected systems显示文摘 | Pant A Seiler P Hedrick J K | | 0，，0018： | 1 |
| 5 | Development of a Colli- sion Avoidance System显示文摘 | SEILER P SONG B HEDRICK J | 1998 | SAE1998，，98： | 1 |
| 6 | An H8 approach to network control显示文摘 | SEILER P SENGUPTA P | 2005 | IEEE Transaction on Automatic Control2005，50，3： | 1 |
| 7 | Crystal structures-a manifesto for the superiority of the valine-derived 5,5-diphenyloxazolidinone as auxiliary in enantioselective organic synthesis 显示文摘 | Gaul G Schweizer B W Seiler P | 2002 | Helvetica Chimica Acta2002，85，： | 1 |
| 8 | Ocular optical aberrations after photorefractive keratectomy for myopia and myopic astigmatism 显示文摘 | Seiler T Kaemmerer M Mierdel P | 2000 | Arch Ophthalmol2000，118，1： | 1 |
| 9 | Evaluation of posttraumatic cerebral blood flow velocities by transcranial Doppler ultrasonograph 显示文摘 | Weber M Grolimund P Seiler RW | 1990 | Neurosurgery1990，27，1： | 1 |
| 10 | Gas exchange and canopy structure of 9-year-old loblolly pine,pitch pine and pitch × loblolly hybrids 显示文摘 | Samuelson L J Seiler J R Feret P P | 1992 | Trees1992，6，： | 1 |
| 11 | Cerebral vasospasm evaluation by transcranial ultrasound correlated with clinical grade and CT visualized subarachnoid hemorrhage 显示文摘 | Grolimund P Aaslid R | 1986 | J Neurosurg1986，64，： | 1 |
| 12 | Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease A randomized,double-blind,placebo-controlled study显示文摘 | Seiler C Tilmann P Kerstin W | 2001 | Circulation2001，104，17： | 1 |
| 13 | Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo显示文摘 | Yang P Seiler MJ Aramant RB Whittemore SR | 2002 | Nerosci Res2002，69，4： | 1 |
| 14 | Decontamination with vaporized hydrogen peroxide is effective against Mycobacterium tuberculosis显示文摘 | Kahnert A Seiler P Stein M | | 0，，06： | 1 |
| 15 | A bounded real lemma for jump sys-tems显示文摘 | SEILER P SENGUPTA R | 2003 | IEEE Transaction on Automatic Control2003，48，9： | 1 |
| 16 | Evaluation and bioinduction of energy components of Jatropha curcas显示文摘 | AUGUSTUS G D P S JAYABALAN M SEILER G J | 2002 | Biomass and Bioenergy2002，23，： | 1 |
| 17 | Ocular optical aberrations after photorefractive keratectomy for myopia and myopic astigmatism显示文摘 | Seiler T Kaemmer M Mierdel P | 2000 | Arch Ophthalmol2000，118，1： | 1 |
| 18 | Estimation with lossy measurements: Jump estimators for jump systems 显示文摘 | SMITH S SEILER P | 2003 | IEEE Transactions on Automatic Control2003，48，12： | 1 |
| 19 | Increased higher 2 order optical aberrations after laser refractive surgery显示文摘 | Mrochen M Kaemmerer M Mierdel P Seiler T | | 0，，3： | 1 |
| 20 | Ocular optical aberrations after photorefractive keratectomy for myopia and myopic astigmatism 显示文摘 | Seiler T Kaemmerer M Mierdel P | 2000 | Arch Ophthalmol2000，118，： | 1 |
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