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您的检索式：作者名="Senfeng Yang"
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| 1 | A comparative study and evaluation of sulfamethoxazole adsorption onto organo-montmorillonites显示文摘Three organo-montmorillonites were prepared using surfactants,and their adsorption behaviors toward sulfamethoxazole(SMX)were investigated.The surfactants used were cetyltrimethyl ammonium bromide(CTMAB),3-(N,N-dimethylhexadecylammonio)propane sulfonate(HDAPS)and 1,3-bis(hexadecyldimethylammonio)-propane dibromide(BHDAP).The properties of the organo-montmorillonites were characterized by X-ray diffraction,scanning electron microscopy and N2adsorption–desorption isotherm measurements.Results showed that the interlayer spacing of montmorillonite was increased and the surface area as well as the morphology were changed.Batch adsorption experiments showed that the surfactant loading amount had a great effect on the adsorption of SMX.The adsorption process was p H dependent and the maximum adsorption capacity was obtained at p H 3 for HDAPS-Mt,while CTMAB-Mt and BHDAP-Mt showed a high removal efficiency at 3–11.The adsorption capacity increased with the initial SMX concentration and contact time but decreased with increasing solution ionic strength.Kinetic data were best described by the pseudo second-order model.Equilibrium data were best represented by the Langmuir model,and the Freundlich constant(n)indicated a favorable adsorption process.The maximum adsorption capacity of SMX was 235.29 mg/g for CTMAB-Mt,155.28 mg/g for HDAPS-Mt and 242.72 mg/g for BHDAP-Mt.Thermodynamic parameters were calculated to evaluate the spontaneity and endothermic or exothermic nature.The adsorption mechanism was found to be dominated by electrostatic interaction,while hydrophobic interaction played a secondary role. | Laifu Lu Manglai Gao Zheng Gu Senfeng Yang Yuening Liu | 2014 | Journal of Environmental Sciences2014，26，12： | 7 |
| 2 | Adsorption of 2 - naphthol on the organo - montmorillonites modified by Gemini surfactants with different spacers 显示文摘 | YANG SENFENG GAO MANGLAI LUO ZHONGXIN | 2014 | Chemical Engineering Journal2014，256，： | 1 |
| 3 | AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells显示文摘While neuroblastoma accounts for 15%of childhood tumor-related deaths,treatments against neuroblastoma remain scarce and mainly consist of cytotoxic chemotherapeutic drugs.Currently,maintenance therapy of differentiation induction is the standard of care for neuroblastoma patients in clinical,especially high-risk patients.However,differentiation therapy is not used as a first-line treatment for neuroblastoma due to low efficacy,unclear mechanism,and few drug options.Through compound library screening,we accidently found the potential differentiation-inducing effect of AKT inhibitor Hu7691.The protein kinase B(AKT)pathway is an important signaling pathway for regulating tumorigenesis and neural differentiation,yet the relation between the AKT pathway and neuroblastoma differentiation remains unclear.Here,we reveal the anti-proliferation and neurogenesis effect of Hu7691 on multiple neuroblastoma cell lines.Further evidence including neurites outgrowth,cell cycle arrest,and differentiation mRNA marker clarified the differentiation-inducing effect of Hu7691.Meanwhile,with the introduction of other AKT inhibitors,it is now clear that multiple AKT inhibitors can induce neuroblastoma differentiation.Furthermore,silencing AKT was found to have the effect of inducing neuroblastoma differentiation.Finally,confirmation of the therapeutic effects of Hu7691 is dependent on inducing differentiation in vivo,suggesting that Hu7691 is a potential molecule against neuroblastoma.Through this study,we not only define the key role of AKT in the progression of neuroblastoma differentiation but also provide potential drugs and key targets for the application of differentiation therapies for neuroblastoma clinically. | Shaowei Bing Senfeng Xiang Zhimei Xia Yilong Wang Zhonghai Guan Jinxin Che Aixiao Xu Xiaowu Dong Ji Cao Bo Yang Jinhu Wang Qiaojun He Meidan Ying | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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