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| 1 | Idarubicin vs doxorubicin in transarterial chemoembolization of intermediate stage hepatocellular carcinoma显示文摘BACKGROUND Liver cancer is the fifth most common cancer and the second cause of cancerrelated deaths worldwide.Transarterial chemoembolization(TACE)is the best treatment of intermediate hepatocellular carcinoma(HCC).Doxorubicin is the most commonly used drug despite a low level of evidence.AIM To compare the objective response rate of idarubicin-based TACE(Ida-TACE)against doxorubicin-based TACE(Dox-TACE)in intermediate stage HCC.METHODS Between January 2012 and December 2014,all patients treated with TACE at our academic hospital were screened.Inclusion criteria were patients with Child-Pugh score A or B,a performance status below or equal to 1,and no prior TACE.Either lipiodol TACE or drug-eluting beads TACE could be performed with 10 mg of idarubicin or 50 mg of doxorubicin.Each patient treated with idarubicin was matched with two doxorubicin-treated patients.The TACE response was assessed by independent radiologists according to the mRECIST criteria.RESULTS Sixty patients were treated with doxorubicin and thirty with idarubicin.There were 93%and 87%of cirrhotic patients and 87%and 70%of Child-Pugh A in the doxorubicin and idarubicin groups,respectively.The median number of HCC per patient was two in both groups with 31%and 26%of single nodules in doxorubicin and idarubicin groups,respectively.Objective response rate after first TACE was 76.7%and 73.3%(P=0.797)with 41.7%and 40.0%complete response in doxorubicin and idarubicin groups,respectively.Progression-free survival was 7.7 mo in both groups,and liver transplant-free survival was 24.9 mo and 21.9 mo in doxorubicin and idarubicin groups,respectively.Safety profiles were similar in both groups,with grade 3-4 adverse events in 35%of Dox-TACE and 43%of Ida-TACEs.CONCLUSION Ida-TACE and Dox-TACE showed comparable results in terms of efficacy and safety.Ida-TACE may represent an interesting alternative to Dox-TACE in the management of patients with intermediate stage HCC. | Gael Stephane Roth Yann Teyssier Melodie Abousalihac Arnaud Seigneurin Julien Ghelfi Christian Sengel Thomas Decaens | 2020 | World Journal of Gastroenterology2020，26，3： | 3 |
| 2 | Saccular intracranial aneurysms:endovascular treatment with mechanical detachable spiral coils显示文摘 | COURTHEOUX P SENGEL C L | 1997 | Radiology1997，202，5： | 1 |
| 3 | Place of arterial embo- liza-tion in severe blunt hepatic trauma: a muhidisciplinary ap-proach 显示文摘 | Monnin V Sengel C Thony F | 2008 | Cardiovasc Intervent Radiol2008，1，： | 1 |
| 4 | Properties of concrete produced with waste concrete aggregate显示文摘 | TOPCU I B SENGEL S | 2004 | Cement and Concrete Research2004，34，8： | 1 |
| 5 | Saccular intracranial aneurysms : endovascular treatment with mechanical detachable spiral coils显示文摘 | Tournade A Courtheoux P Sengel C | 1997 | Radiology1997，202，2： | 1 |
| 6 | Management of blunt trauma of the kidney 显示文摘 | SAIDI A DESCOTES J T SENGEL C | 2004 | Prog Urol2004，14，4： | 1 |
| 7 | Isolation and primary structure of NGAL, a novel protein associated with hu- man neutrophil gelatinase 显示文摘 | KJELDSEN L JOHNSEN AH SENGEL H | 1993 | Biol Chem1993，268，14： | 1 |
| 8 | Reduced antimicrobial potencies of Oxytetraeycline, Tylosin, Sulfadiazin, Streptomycin, Ciprofloxacin and Olaquindox due to environmental processes显示文摘 | Halling-Sφrensen B Sengelφv G Ingerslev L | 2003 | Archives of Environmental Contamination and Toxicology2003，44，： | 1 |
| 9 | Properties of concretes produced with waste concrete aggregate显示文摘 | TOPCU I B SENGEL S | 2004 | Cement and Concrete Research2004，34，8： | 1 |
| 10 | Bacterial antibiotic resistance levels in Danish farmland as a result of treatment with pig manure slurry显示文摘 | Sengel(o)v G Agerso Y Halling-S(o)rensen B | | 0，，07： | 1 |
| 11 | Toxicity oftetracyclines and tetracycline degradation products toenvironmentally relevant bacteria,including selected tetracycline-resistant bacteria显示文摘 | Halling-Srensen B Sengelv G Tjrnelund J | 2002 | Archives of Environmental Contaminationand Toxicology2002，42，3： | 1 |
| 12 | Mobiliza-tion of granules and secretory vesicles duriug in Vivoexudation of human neutropils显示文摘 | Sengel?v H Follin P Kjeldsen L | 1995 | J Immunol1995，154，8： | 1 |
| 13 | Properties of concretes produced with waste concrete aggregate显示文摘 | TOPCU I B SENGEL S | 2004 | Cement and Concrete Research2004，34，8： | 1 |
| 14 | Long-term survival results of a randomized trial compa- ring gemcitabine/cisplatin and methotrexate/vinblas- tine/doxorubicin/cisplatin in patients with locally ad- vanced and metastatic bladder cancer显示文摘 | Roberts J T vonder Maase H Sengel L | 2006 | Ann Oncol2006，175，： | 1 |
| 15 | Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria,including selected tetracycline-resistant bacteria显示文摘 | Halling-S(o)rensen B Sengel(o)v G Tj(o)rnelund J | 2001 | Earth and Environmental Science2001，42，3： | 1 |
| 16 | Saccular intracranial aneurysms: endovascular treatment with mechanical detachable spiral coils显示文摘 | Tournade A Courtheoux P Sengel C | 1997 | Radiology1997，202，2： | 1 |
| 17 | Properties of concretes produced with waste concrete aggregate 显示文摘 | TOPCU I B SENGEL S | 2004 | Cement and Concrete Research2004，34，8： | 1 |
| 18 | Association of HMGB1 Polymorphisms with Outcome after Allogeneic Hematopoietic Cell Transplantation显示文摘 | Brian Kornblit Tania Masmas S?ren L. Petersen Hans O. Madsen Carsten Heilmann Lone Schejbel Henrik Sengel?v Klaus Müller Peter Garred Lars Vindel?v | 2010 | Biology of Blood and Marrow Transplantation2010，，2： | 1 |
| 19 | Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline- resistant bacteria 显示文摘 | Hailing S Rensen B Sengel V G | 2002 | Arehives of Environmental Contamination and Toxicology2002，2，3： | 1 |
| 20 | Toxicity of tetracyclines and tetracycline degradation products to en- vironmentally relevant bacteria, including selected tetracy- cline-resistant bacteria显示文摘 | Halling-Sorensen B Sengel ov G Tjomelund J | 2002 | Archives of Environmental Con- tamination and Toxicology2002，42，3： | 1 |
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