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| 1 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | Reaction of methyl heptanoate hydrodeoxygenation on sulphided catalysts 显示文摘 | SENOL O I RYYMIN E M VILJAVA T R | 2007 | Journal of Molecular Catalysis A: Chemical2007，268，12： | 1 |
| 3 | Intertriginous plasmacytosis with plasmoacanthoma:report of a typical case and review of the literature 显示文摘 | Senol M Ozcan A Aydin NE | 2008 | Int J Dermatol2008，47，3： | 1 |
| 4 | Effect of hydrogen sulphide on the hydrodeoxygenation of aromatic and aliphatic oxygenates on sulphided catalysts 显示文摘 | SENOL O I RYYMIN E M VILJAVA T R | 2007 | Journal of Molecular Catalysis (A) : Chemical2007，277，12： | 1 |
| 5 | Carbapenem versus fosfomycin tromethanol in the treatment of extended-spectrum betalaetamase-producing Escherichia coli-related complicated lower urinary tract infection显示文摘 | Senol S Tasbakan M Pullukeu H | 2010 | J Chemother2010，22，5： | 1 |
| 6 | Immunohistochemical study on distribution of enduorcine cells in gatract of flow- er fish 显示文摘 | Cinar K Senol N Ozen M R | 2006 | World J Gastroenterol2006，12，42： | 1 |
| 7 | Evaluation of gravity data by using artificial neural networks case study: Seferihisar geothermal area (Western Turkey) 显示文摘 | KAFTAN I SALK M SENOL Y | 2011 | Journal of Applied Geophysics2011，75，4： | 1 |
| 8 | Effect of hydrogen sulphide on the hydrodeoxygenation of aromatic and aliphatic oxygenates on sulphided catalysts 显示文摘 | Senol O f Ryymin E M Viljava T R | 2007 | Journal of Molecular Catalysis A: Chemical2007，277，12： | 1 |
| 9 | Factors affecting postoperative morbidity and mortality in destroyed lung 显示文摘 | Halezeroglu S Keles M Uysal A Celik M Senol C? Haci-ibrahimoglu G Arman B | 1997 | Ann Thorae Surg1997，64，6： | 1 |
| 10 | Video-assisted thoracoscopic surgery:experience with 341 cases显示文摘 | Halezeroglu S Senol C | 1998 | Eur J Cardiothorac Surg1998，14，2： | 1 |
| 11 | Hydrodeoxygenation of aliphatic esters on sulphided Mo Ni/γ-Al2O3 and Co-Mo/γ-Al2O3 catalyst: The effect of water显示文摘 | SENOL O I RYYMIN E M KRAUSE A O I | 2005 | Catalysis Today2005，106，14： | 1 |
| 12 | Effect of hydrogen sulphide on the hydrodeoxygenation of aromatic and aliphatic oxygenates on sulphided catalysts 显示文摘 | Senol O I Ryymin E M Viljava T R | 2007 | Journal of Molecular Catalysis A: Chemical2007，277，12： | 1 |
| 13 | Humoral immune response against 38-kDa and 16-kDa mycobacterial antigens in tuberculosis显示文摘 | Senol G Erer OF Yalcin YA Coskun M Gündüz AT Bimen C Ertas M Ozkan SA | 2007 | Eur Respir J2007，29，1： | 1 |
| 14 | A sensitive enzyme immunoassy for human basic fibroblast growth factor显示文摘 | Watanabe H Hori A Senol M | 1991 | Biochemical and Biophysical Research Communications1991，175，1： | 1 |
| 15 | Evaluation of mass exchange during osmotic dehydration of carrots using response surface methodology 显示文摘 | BURHAN M PAUL U SENOL I | 2004 | Journal of Food Engineering2004，，65： | 1 |
| 16 | Reactions of methyl heptanoate hydrodeoxygenation on sulphided catalysts 显示文摘 | Senol O I Ryymin E M Viljava T R | 2007 | Journal of Molecular Catalysis A: Chemical2007，268，12： | 1 |
| 17 | Giant vascular eccrine spiradenoma显示文摘 | SENOL M OZCAN A SASMAZ S | 1998 | Int J Dermatol1998，37，3： | 1 |
| 18 | Optimum usage of prilocaine-lidocaine cream in premature ejaculation 显示文摘 | ATIKELER M K GECIT I SENOL F A | 2002 | Andrologia2002，34，6： | 1 |
| 19 | Effect of hydrogen sulphide on the hydrodeoxygenation of aromatic and aliphatic oxygenates on sulphided catalysts 显示文摘 | Senol O I Ryymin E M Viljava T R | 2007 | Journal of Molecular Catalysis A : Chemical2007，277，12： | 1 |
| 20 | Intertriginous plasmacytosiswith plasmoacanthoma:report of a typical case and review of theliterature显示文摘 | Senol M Ozcan A Aydin NE et ai | 2008 | J Int J Dermatol2008，47，： | 1 |
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