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| 1 | From fatty liver to fibrosis:A tale of “second hit”显示文摘Although much is known about how fat accumulates in the liver,much remains unknown about how this causes sustained hepatocellular injury.The consequences of injury are recognized as nonalcoholic steatohepatitis(NASH) and progressive fibrosis.The accumulation of fat within the hepatocytes sensitizes the liver to injury from a variety of causes and the regenerative capacity of a fatty liver is impaired.An additional stressor is sometimes referred to as a 'second hit' in a paradigm that identifies the accumulation of fat as the 'first hit'.Possible candidates for the second hit include increased oxidative stress,lipid peroxidation and release of toxic products such as malondialdehyde and 4-hydroxynonenal,decreased antioxidants,adipocytokines,transforming growth factor(TGF)-β,Fas ligand,mitochondrial dysfunction,fatty acid oxidation by CYPs(CYP 2E1,4A10 and 4A14),and peroxisomes,excess iron,small intestinal bacterial overgrowth,and the generation of gut-derived toxins such as lipopolysaccharide and ethanol.Oxidative stress is one of the most popular proposed mechanisms of hepatocellular injury.Previous studies have specifically observed increased plasma and tissue levels of oxidative stress markers and lipid peroxidation products,with reduced hepatic and plasma levels of antioxidants.There is also some indirect evidence of the benefit of antioxidants such as vitamin E,S-adenosylmethionine,betaine,phlebotomy to remove iron,and N-acetylcysteine in NASH.However,a causal relationship or a pathogenic link between NASH and oxidative stress has not been established so far.A number of sources of increased reactive oxygen species production have been established in NASH that include proinflammatory cytokines such as tumor necrosis factor(TNF)-α,iron overload,overburdened and dysfunctional mitochondria,CYPs,and peroxisomes.Briefly,the pathogenesis of NASH is multifactorial and excess intracellular fatty acids,oxidant stress,ATP depletion,and mitochondrial dysfunction are important causes of hepatocellular injury in the steatotic liver. | Metin Basaranoglu Gkcen Basaranoglu Hakan Sentürk | 2013 | World Journal of Gastroenterology2013，19，8： | 28 |
| 2 | Clindamycin-induced acute cholestatic hepatitis显示文摘我们为牙齿的感染在 clindamycin 的管理以后在一个 42 岁的女人报导尖锐 hepatotoxicity 的一个案例。在治疗的 6 d 以后,她有疲劳,恶心,呕吐,厌食,瘙痒和黄疸。她的实验室分析显示出丙氨酸 aminotransferase (中高音) , 1795 IU/L (正常范围 0-40 ) ;aspartate aminotransferase (著名计算机生产厂商) , 1337 IU/L (正常范围 5-34 ) ;硷性磷酸酯酶(高山) , 339 IU/L (正常范围 40-150 ) ;gamma-glutamyl transpeptidase (GGT ) , 148 IU/L (正常范围 9-64 IU/L ) ;全部的胆红素, 4.1 mg/dL;直接胆红素, 2.9 mg/dL 和前凝血酶时间(磅) , 13.5 s 与国际规范的比率(INR ) , 1.04。她被就医,与立即的药中止。她的肝活体检视标本显示出混合类型(肝细胞和胆汁郁积的) 肝的损害,与导致药的肝炎的诊断兼容。用 Naranjo 概率规模的一个客观诱发性评价建议 clindamycin 是尖锐肝炎的可能的原因。在易受影响的个人, clindamycin 使用可以导致尖锐混合类型肝毒性。如果在严重肝损伤被建立以前,这药被中止,完全的恢复可能是可能的。 | Cem Aygün Orhan Kocaman Yesim Gürbüz mer Sentürk Sadettin Hülagü | 2007 | World Journal of Gastroenterology2007，13，40： | 6 |
| 3 | The effect of one year's swimming exercise on oxidant stress and antioxidant capacity in aged rats显示文摘 | Gündüz F Sentürk U K Kuru O | 2004 | Physiol Res2004，，53： | 1 |
| 4 | The antioxidant function of high-density lipoproteins:a new paradigm in atherosclerosis显示文摘 | Tomás M Latorre G SentíM | 2004 | Rev EspCardiol2004，57，6： | 1 |
| 5 | Estrogen protects the Liver and intestines against sepsis-induced injury in rats显示文摘 | Sent G Arbak S Kurtaran P | 2005 | J Surgic Res2005，128，1： | 1 |
| 6 | Epidemiology and effect on production parameters of an outbreak of inclusion body hepatitis in broilers显示文摘 | Sentíes-Cué C G Wills R W Stayer P A Burleson M A Magee D L | | 0，，01： | 1 |
| 7 | Kinetic evaluation and performance of a mesophilic anaerobic contact reactor treating medium-strength food-processing wastewater显示文摘 | Sentürk E Ince M Onkal Engin G | | 0，，： | 1 |
| 8 | Environmental control of daily stem radius increment in the montane conifer Cedrus libani显示文摘Growth response of conifers is species-specific and depends on site and climate conditions.Studies on daily radial stem growth use different analytical approaches to determine species reactions to environmental conditions.These results contribute to improve forecasts of tree growth under a changing climate.During 2013 and2014,radial stem growth of 33 mature Cedrus libani individuals growing under different climatic conditions in Turkey and Germany was monitored hourly using high precision point dendrometers.Stem radius increments(SRI)were extracted from dendrometer readings.The annual course of SRI showed site-specific patterns with mean daily values ranging between 9.9 and 29.3μm over the growing season.Correlation and principal component analyses indicated that humidity and low temperatures during the growing season favored SRI.Multiple regression analyses demonstrated that precipitation and relative air humidity were the most important factors influencing daily SRI.Climate-growth relationships were further evaluated using the regression tree method.Precipitation was the most significant factor on daily SRI for all sites.The close coupling of SRI to relative air humidity and precipitation underlines the importance of stem water status for radial stem growth of C.libani which is native to regions with summer drought.It further explains the superior growth of C.libani in Germany. | Aylin Güney Serkan Gülsoy Ozdemir Sentürk Armin Niessner Manfred Küppers | 2020 | Journal of Forestry Research2020，31，4： | 0 |
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