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| 1 | Antioxidant activities of Indigofera cassioides Rottl.Ex.DC.using various in vitro assay models显示文摘Objective:To evaluate the antioxidant potential of methanolic leaf extract of Indigofera cassioides(MEIC) using various in vilro antioxidant assay systems.Methods:Antioxidant and free radical scavenging activity of MEIC was assayed by using different in vitro models like ABTS, DPPH,nitric oxide,superoxide,hydrogen peroxide and hydroxyl radical.Reductive ability of the extract was tested by the complex formation with potassium ferricyanide.Further total phenol and flavonoid contents of the crude extract were also determined.Rutin and ascorbic acid were used as standards.Results:MEIC exhibited potent and concentration dependent free radical scavenging activity in all the tested models.Reductive ability was also found to increase with increase in MEIC concentration.Total phenol and flavonoid content determination showed that the extract is rich in phenols and flavonoids.Conclusions:All the results of the in vitro antioxidant assays reveal potent antioxidant and free radical scavenging activity of the leaves of Indigofera cassioides,equivalent to that of standard ascorbic acid and rutin.This potent antioxidant activity may be attributed to its high phenolic and flavonoid contents. | R Senthil Kumar B Rajkapoor P Perumal | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 15 |
| 2 | In vitro and in vivo anticancer activity of Indigofera cassioides Rottl.Ex. DC.显示文摘Objective:To evaluate the antitumor,cytotoxic and antioxidant activities of methanolic leaf extract of Indigofera cassioides(MEIC) against transplantable tumors and human cancer cell lines.Methods:MEIC was investigated for its short term cytotoxicity on EAC and DLA cells by trypan blue dye exclusion method and in vitro cytotoxicity on HeLa,HEp-2,HEpG-2,MCF-7, HT-29,Vero and NIH 3T3 cells by MTT assay.In vivo antitumor activity was studied on EAC and DLA tumor bearing mice.Activity was assessed by monitoring the mean survival time,effect on hematological parameters,antioxidant enzyme levels and solid tumor volume.Results:MEIC exhibit potent in vitro cytotoxicity against all the tested cancer cell lines,but it was found to be safe on normal cells.The extract significantly(P<0.001) increase the mean survival time and also have a protective effect on the hemopoietic system at the tested dose levels(200 and 400 mg/kg). The extract prevented lipid peroxidation and restored the antioxidant enzymes catalase, superoxide dismutase,glutathione peroxidase and glutathione-s-transferase in the liver of tumor control animals.It also significandy(P<0.01) reduce the solid tumor volume.Conclusions:The results strongly support that MEIC shows potent antitumor and cytotoxic effects against EAC,DLA and human cancer cell lines.The extract prevents lipid peroxidation and promotes the enzymatic antioxidant defense system in tumor bearing animals which might be due to activities like scavenging of free radicals by the phytochemicals in MEIC. | Raju Senthil Kumar Balasubramanian Rajkapoor Perumal Perumal | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 6 |
| 3 | Synthesis,characterization and sintering behavior influencing mechanical,thermal and physical properties of pure cordierite and cordierite-ceria显示文摘The study of cordierite ceramic is the need of the hour in present technological world for various advanced engineering applications.Cordierite,which has relatively poor mechanical properties,has induced the use of various dopants to study the improvement in mechanical properties.Thirst of seeking new materials with good mechanical properties has revived the research on ceria doped cordierite.Present research conducted on pure cordierite and ceria doped cordierite ceramics has investigated the results of characterization and studied their suitability.Pure cordierite and cordierite-ceria(CeO_(2))composite ceramics synthesized for various stoichiometric composition(5-20 wt%)were compacted at 240 MPa and sintered between 600℃and 1350℃for 3 h.The characterization techniques used in this study were X-ray diffraction(XRD),thermogravimetric(TG)analysis and Fourier transform infrared(FTIR).The density was calculated using the Archimedes principle.Influence of the ceria addition on cordierite’s mechanical properties such as hardness,flexural strength and fracture toughness and on thermal properties as thermal expansion was studied.XRD results confirmed the presence of cordierite and ceria in the samples heat treated at 1350℃.Results of FTIR and TG analyses revealed the formation of cordierite and the effect of ceria addition.The mechanical properties studied were found to be encouraging and confirmed the suitability of cordierite-ceria as an alternate material for cordierite. | Marikkannan SENTHIL KUMAR Ayyasamy ELAYA PERUMAL T.R.VIJAYARAM | 2015 | Journal of Advanced Ceramics2015，4，1： | 3 |
| 4 | Implications of the presence of an aberrant right hepatic artery in patients undergoing pancreaticoduodenectomy显示文摘AIM:To analyze the differences in outcomes and the clinical impact following pancreatoduodenectomy(PD)in patients with and without aberrant right hepatic artery(aRHA).METHODS:All patients undergoing PD between January 2008 and December 2012 were divided into two groups,one with aRHA and the other without.These groups were compared to identify differences in the intraoperative variables,the oncological clearance and the postoperative morbidity,mortality and hospital stay.RESULTS:A total of 225 patients underwent PD,of which 43(19.1%)patients were found to have eitheraccessory or replaced right hepatic arteries(aRHA group).The aRHA was preserved in 79%of the patients.There was no significant difference in the intraoperative blood loss but operative time was prolonged,reflecting the complexity of the procedure[420±44(240-540)min vs 480±45(300-600)min,P<0.05)].There were no differences in the incidence of postoperative complications(pancreatic leak,pancreatic fistula,delayed gastric emptying and mortality)and hospital stay.Oncological clearance in the form of positive resection margins[13(7.1%)vs 3(6.9%)]and lymph node yield were also similar in the two groups.CONCLUSION:An aRHA is found in approximately one fifth of patients undergoing PD.Preservation is technically possible in most patients and can increase the operative complexity but does not negatively affect the safety or oncological outcomes of the procedure. | Ashwin Rammohan Ravichandran Palaniappan Anbalagan Pitchaimuthu Kamalakannan Rajendran Senthil Kumar Perumal Kesavan Balaraman Ravi Ramasamy Jeswanth Sathyanesan Manoharan Govindan | 2014 | World Journal of Gastrointestinal Surgery2014，6，1： | 3 |
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