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| 1 | Histone Acetyltransferase AtGCN5/HAG1 Is a Versatile Regulator of Developmental and Inducible Gene Expression in Arabidopsis显示文摘Histone acetylation/deacetylation 是一个动态过程并且在基因规定起一个重要作用。Histone acetylation 动态平衡被 histone acetyltransferases (帽子) 和 deacetylases (HDAC ) 的对手行动调整。植物染色体编码多重帽子和 HDAC。在许多植物开发的一个必要角色处理的 Arabidopsis 帽子基因 AtGCN5/HAG1plays 例如分裂组织功能,房间区别,叶和花的 organogenesis ,并且对象光和寒冷那样的环境条件的回答,在长期的发展开关和短期的可诱导的基因表示的规定显示这顶帽子的一个重要角色。AtGCN5 目标到很多倡导者并且为几 histone H3 离氨酸残余的 acetylation 被要求。到目标倡导者的 AtGCN5 的招募是可能的被和 DNA 有约束力的抄写因素的直接或间接的相互作用或由和 acetylated histone 离氨酸残余的相互作用在目标上调停。在 AtGCN5 和另外的帽子和 HDAC 之间的相互影响被表明控制特定的规章的小径。在光可诱导的基因表示的 AtGCN5 的角色的分析在为 priming 准备染色质承诺建议 AtGCN5 的功能在植物的可诱导的基因激活。 | Caroline Servet Natalia Conde e Silva Dao-Xiu Zhou | 2010 | Molecular Plant2010，3，4： | 14 |
| 2 | Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis显示文摘MicroRNAs (miRNA ) 指导在基因表示的一个重要角色在植物为到环境条件的发展进程和回答要求了的顺序特定的 posttranscriptional 基因 silencing 玩。然而,很少对 transcriptional 和 miRNA 表示的 posttranscriptional 规定被知道。Histone acetylation 在染色质改变起一个重要作用并且为基因激活被要求。由在 Arabidopsis 的异种分析 miRNAs 和相应主要 miRNAs 的子集的累积,我们显示出那 histone acetyltransferase GCN5 (一般控制非镇压的 protein5 )在 miRNA 上有一般压抑的效果生产,当它为一个子集的表示被要求时(例如压力可诱导) MIRNA 基因。在 miRNA 生产的 GCN5 的一般否定功能多半通过象 DICER LIKE1 (DCL1 ) 那样的 miRNA 机械基因的间接压抑被完成,有锯齿(SE ) ,偏下性的 LEAVES1 (HYL1 ) 和 ARGONAUTE1 (AGO1 ) 。染色质 immunoprecipitation 试金表明 GCN5 指向到 MIRNA 基因的一个子集并且为在这些 loci 的 histone H3 离氨酸 14 的 acetylation 被要求。而且,由 trichostatin 的 histone deacetylation 的抑制一个处理或在 histone deacetylase,基因异种损害了某些 miRNAs 的累积。这些数据一起建议 Arabidopsis GCN5 在 transcriptional 和 posttranscriptional 层次防碍 miRNA 小径, histone acetylation/deacetylation 是涉及 miRNA 的规定的 epigenetic 机制生产。 | Wanhui Kim Moussa Benhamed Caroline Servet David Latrasse Wei Zhang Marianne Delarue Dao-Xiu Zhou | 2009 | Cell Research2009，19，7： | 10 |
| 3 | Variation of vertical and horizontal drilling rates depending on some rock properties in the marble quarries显示文摘The main objective of this study is to determine the rates of vertically and horizontally oriented drilling processes in marble quarries and to observe the factors affecting the drilling rates in terms of physical and mechanical properties of the rocks. In situ drilling tests were performed in different marble quarries with different marble types and drilling times and penetration rates for a series of successive depthincrements were trying to be determined under vertically and horizontally oriented conditions. In order to understand the relation between the parameters that are investigated within the scope of this research, uniaxial compressive strength, Brazilian tensile strength, impact strength, Bohme abrasion strength, P-wave velocity, porosity, unit volume weight, Schmidt hardness index and brittleness index values were correlated with the drilling rates. It was noticed that the porosity and unit volume weight could be taken as the key parameters among them for obtaining meaningful correlation with drilling performance. It was also observed that the physical and mechanical rock properties are more relevant in vertical drilling than horizontal drilling. | Servet Demirdag Nazmi Sengun Ibrahim Ugur Tamer Efe Deniz Akbay Rasit Altindag | 2014 | International Journal of Mining Science and Technology2014，24，2： | 7 |
| 4 | Same-day colonoscopy preparation with Senna alkaloids and bisacodyl tablets:A pilot study显示文摘AIM:To evaluate the efficacy of same-day bowel preparation with Senna alkaloids combined with bisacodyl tablets in routine colonoscopy procedures.METHODS:Between March and June 2013,a sameday bowel preparation was implemented in our endoscopy unit.The preparation consisted of a semi-liquid,fiber-free diet one day prior to the procedure,with two bisacodyl tablets after lunch and dinner,and 250 mL of Senna alkaloid with 1.5 L of drinking water at 6 am the day of the procedure.The quality control parameters of colonoscopy were evaluated and implemented according to the guidelines of the American Society for Gastrointestinal Endoscopy.The pre-procedure,duringprocedure and post-procedure patient data were collected and analyzed:(1) pre-procedure(age,gender,comorbid diseases,colonoscopy indications,complete lack of compliance with the bowel preparation protocol);(2) during-procedure(sedation dose,duration of colonoscopy,withdrawal time,cecal intubation rate,polyp detection rate,Boston Bowel Preparation Scores and presence of foam and clear liquid); and(3) postprocedure(visual analogue scale score,pain during the procedure,patient satisfaction and premature withdrawal due to the insufficient bowel preparation).RESULTS:A total of 75 patients were included in this study with a mean age of 54.64 ± 13.29 years; 53.3%(40/75) were female and 46.7%(35/75) were male.A complete lack of compliance with the bowel preparation protocol was seen in 6.7% of patients(5/75).The mean total duration of colonoscopy was 16.12 ± 6.51 min,and the mean withdrawal time was 8.89 ± 4.07 min.The cecal intubation rate was 93.8%(61/64) and the polyp detection rate was 40%(30/75).The mean Boston Bowel Preparation Score was 7.38 ± 1.81,with the following distribution:right colon,2.34 ± 0.89; transverse colon,2.52 ± 0.67; left colon,2.52 ± 0.63.The mean visual analogue scale score was 4.59 ± 1.57.Due to insufficient bowel preparation,seven patients(7/75; 9.3%) were asked to repeat the procedure.Of these,five patients had poor or modest compliance with the protocol,and two patients reported constipation.Premature withdrawal due to insufficient bowel preparation was 2.7%(2/75).The overall satisfaction with the protocol was 86.7%(65/75),with patients reporting they would prefer the same protocol in a repeat procedure.CONCLUSION:The same-day administration of Senna alkaloids appears to be a safe and effective bowel cleansing protocol for colonoscopy procedures. | Erdinc Yenidogan Ismail Okan Huseyin Ayhan Kayaoglu Gokhan Giray Akgul Mufit Sansal Servet Tali Zeki Ozsoy Mustafa Sahin | 2014 | World Journal of Gastroenterology2014，20，41： | 7 |
| 5 | One-step electrochemical reduction of stibnite concentrate in molten borax显示文摘In this study,antimony production from a stibnite concentrate(Sb2S3)was performed in one step using a molten salt electrolysis method and borax as an electrolyte.Electrochemical reduction of the stibnite concentrate was performed at 800℃under galvanostatic conditions and explained in detail by the reactions and intermediate compounds formed in the borax.The effects of current density(100 800 mA cm^-2)and electrolysis time(10 40 min)on cathodic current efficiency and antimony yields were systematically investigated.During the highest current efficiency,which was obtained at 600 mA cm^-2,direct metal production was possible with 62%cathodic current efficiency and approximately 6 kWh/kg energy consumption.At the end of the 40-min electrolysis duration at 600 mA cm^-2 current density,antimony reduction reached 30.7 g and 99%of the antimony fed to the cell was obtained as metal. | Levent Kartal Mehmet Baris Daryal Güldem Kartal Sireli Servet Timur | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，10： | 6 |
| 6 | Effects of glutamine and curcumin on bacterial translocation in jaundiced rats显示文摘AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice. | Oguzhan Karatepe Ersin Acet Muharrem Battal Gokhan Adas Ahu Kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali Servet Karahan | 2010 | World Journal of Gastroenterology2010，16，34： | 5 |
| 7 | Cytomegalovirus colitis in a patient with Behcet’s disease receiving tumor necrosis factor alpha inhibitory treatment显示文摘Anti-tumor necrosis factor alpha (TNF-α) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet’s patient whose disease was complicated by cytomegalovirus (CMV) colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral infections.CMV infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents. | Ismail Sari Merih Birlik Can Gonen Servet Akar Duygu Gurel Fatos Onen Nurullah Akkoc | 2008 | World Journal of Gastroenterology2008，14，18： | 5 |
| 8 | Effects of geoclimatic factors on the variability in Pinus pinea cone, seed, and seedling traits in Turkey native habitats显示文摘Background:Stone pine(Pinus pinea L.)is harvested for its edible kernels.It is an important forest tree species,and also plays an important role in afforestation.Successful afforestation activities strongly depend on the quality of seeds and seedlings.Five eastern native populations of stone pine were analyzed,in terms of their geographical and climatic parameters,in order to identify their cone,seed,pine nut,and seedling traits.With this regard,we aimed to contribute to the reforestation,yield,and breeding of this species.Results:All native populations occur in the sub-humid bioclimatic zone,according to Emberger’s bioclimatic classification,ranging 74.7-63.2 of Emberger’s Q Index value(Q),which synthesizes humidity and temperature,with lower values indicating more arid conditions.With regard to geographical factors,altitude was found to have the greatest effect on cone diameter and seed weight,while there was a weak correlation of cone,seed,and pine nut dimension with longitude and latitude.In terms of climatic factors,Q and mean of the maximum temperature of June,July,and August(ME)were found to be the main drivers behind significant effects in cone,seed,and pine nut morphometric traits.The most negative effect on seed number cone−1(r:−0.897),pine nut number cone−1(r:−0.923),pine nut yield(r:−0.903),and pine nut weight(r:−0.878)was Q,whereas cone diameter,seed length,and seed weight were positively correlated with the ME(r:0.939,r:0.889,and r:0.866,respectively).Cone and seed diameter and seed weight increased with decreasing summer drought index(r:−0.806,r:−0.846,and r:−0.866,respectively).Rainfall in the June of the third year prior to harvest time(RJ)had a negative effect on the percentage of sound seeds per cone.Annual rainfall in the third year prior to harvest time(AR)significantly affected pine nut weight(r:0.889),although rainfall during summer had a negative effect.The empty seed ratio of the different populations ranged from 20 to 68%,while considering all populations,the empty seed ratio was 46%.Conclusions:The study suggests that the Q Index and ME should be taken into account to determine cone to pine nut yield.With this regard,plantations of stone pine should be established on sub-humid areas and Q values should not exceed 75. | Safa Balekoglu Servet Caliskan Hüseyin Dirik | 2020 | Ecological Processes2020，9，1： | 4 |
| 9 | 超声乳化术治疗假性剥脱综合征白内障患者的疗效分析(英文)显示文摘目的:评估在白内障超声乳化手术时使用适当的手术技巧及相应设备对假性剥脱综合征白内障患者的视力及术中、术后并发症的影响。方法:回顾性研究。选取53例67眼假性剥脱综合征白内障患者接受超声乳化及人工晶状体植入术。平均年龄71.68±9.96(53~89)岁,其中男性24例(45%),女性29例(55%),包括核性、皮质性及后囊下和成熟期的白内障。结果:核性白内障较其他类型更为常见(P=0.00)。术前平均最佳矫正视力为0.99±0.30(0.40~1.50)LogM AR,术后平均最佳矫正视力为0.32±0.31(0.00~1.00)LogM AR(P=0.00)。运用虹膜牵拉器12眼(18%)。囊袋张力环植入15眼(22%),其中按计划植入8眼(12%),未计划7眼(10%)。后囊破裂4眼(6%),其中玻璃体脱出2眼(3%),并接受前段玻璃体切割术;且由于后囊破裂较大,此2眼(3%)转为白内障囊外摘除术。持续性角膜水肿4眼(6%),前房反应5眼(7%)。人工晶体脱位4眼(6%),仅1眼(1.5%)需复位。后囊混浊并接受Nd:YAG激光后囊切开术13眼(20%)。结论:假性剥脱综合征白内障患者术后视力良好,但术中及术后可能出现的并发症包括后囊破裂,玻璃体脱出,转为白内障囊外摘除术,持续性角膜水肿,前房反应及人工晶状体脱位。为避免并发症的发生,适当的手术技巧和相应设备的使用在手术时是必不可少的。 | Servet Cetinkaya Yasemin Fatma Cetinkaya Zeynep Dadaci Nursen Oncel Acir | 2016 | 国际眼科杂志2016，16，6： | 4 |
| 10 | Direct electrochemical reduction of copper sulfide in molten borax显示文摘In this study,for the first time,direct copper production from copper sulfide was carried out via direct electrochemical reduction method using inexpensive and stable molten borax electrolyte.The effects of current density(100–800 mA/cm^2)and electrolysis time(15–90 min)on both the cathodic current efficiency and copper yield were systematically investigated in consideration of possible electrochemical/chemical reactions at 1200℃.The copper production yield reached 98.09%after 90 min of electrolysis at a current density of 600 mA/cm^2.Direct metal production was shown to be possible with 6 kWh/kg energy consumption at a 600 mA/cm2 current density,at which the highest current efficiency(41%)was obtained.The suggested method can also be applied to metal/alloy production from single-and mixed-metal sulfides coming from primary production and precipitated sulfides,which are produced in the mining and metallurgical industries during treatment of process solutions or wastewaters. | Levent Kartal Servet Timur | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，8： | 4 |
| 11 | High adiponectin levels fail to protect against the risk of hypertension and,in women,against coronary disease:involvement in autoimmunity?显示文摘AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome.METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements(n=1224)were analyzed prospectively at a mean of 3.8 years’follow-up,using continuous values or sex-specific tertiles.Total adiponectin was assayed by an ELISA kit.Type-2 diabetes was identified by criteria of the American Diabetes Association.Hypertension was defined as a blood pressure≥140 mmHg and/or≥90 mmHg and/or use of antihypertensive medication.Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders.RESULTS:In models of multiple linear regression,sex hormone-binding globulin,fasting insulin(inverse)and,in men,age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine.Cox regression analyses for incident coronary heart disease(CHD),adjusted for sex,age,non-HDL cholesterol,waist circumference and C-reactive protein,revealed significant inverse association with adiponectin tertiles in men but not women(HR=0.66;95%CI:0.32-1.38 for highest tertile).Cox regression for type-2 diabetes in a similar model(wherein glucose replaced non-HDL cholesterol),adiponectin tertiles appeared to protect in each gender.HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles(P-trend=0.67).CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and,in women,against CHD,presumably paralleling impairment in renal function as well.Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying. | Altan Onat Mesut Aydln Günay Can Bayram Kroglu Ahmet Karagz Servet Altay | 2013 | World Journal of Diabetes2013，4，5： | 3 |
| 12 | 前房内给予莫西沙星预防眼内炎在白内障手术中的应用(英文)显示文摘目的:评价在白内障手术中采用前房内应用莫西沙星预防眼内炎的安全性和效果。 方法:选取2012年1-6 mo在我院行白内障手术患者65例65眼。部分患者手术结束时前房给予莫西沙星,另外一部分作为对照组未使用莫西沙星。对患者术前和术后logMAR最佳矫正视力、眼内压、角膜水肿、前房形态进行检查。 结果:共33例患者(男19,女14)使用了莫西沙星,平均年龄64.81±11.61(41~82)岁;32例患者(男15,女17)没有使用,平均年龄65.43±11.10(42-81)岁。患者的年龄(P=0.827)和性别(P=0.396)无统计学差异。术前两组的最佳矫正视力均接近20/130。术后,莫西沙星组和对照组的最佳矫正视力分别为20/25和20/23( P=0.160)。术前莫西沙星组眼内压为14.93±2.77(11-21) mmHg,对照组为15.06±2.42(12-21)mmHg(P=0.850)。术后,两组眼内压均无统计学差异[莫西沙星组:14.06±2.31(10-19) mmHg;对照组:14.03±2.36(10-19) mmHg ( P=0.726)]。两组角膜水肿(P=0.623)与前房细胞发生率(P=0.726)均无统计学差异。 结论:白内障手术后给予莫西沙星预防眼内炎是安全而有效的。 | Servet Cetinkaya Yasemin F Cetinkaya Nursen O Acir Zeynep Dadaci | 2015 | 国际眼科杂志2015，15，10： | 2 |
| 13 | Generalized contraction mapping principle in intuitionistic Menger spaces and application to differential equations显示文摘Using the idea of Atanassov, we define the notion of intuitionistic Menger spaces as a netural generalizations of Menger spaces due to Menger. We also obtain a new generalized contraction mapping and utilize this contraction mapping to prove the existance theorems of solutions to differential equations in intuitionistic Menger spaces. | Servet Kutukcu Adnan Tuna Atakan T. Yakut | 2007 | Applied Mathematics and Mechanics(English Edition)2007，28，6： | 2 |
| 14 | An investigation of copper and selenium recovery from copper anode slimes显示文摘 | Yasin Kilic Guldem Kartal Servet Timur | 2013 | International Journal of Mineral Processing2013，，： | 2 |
| 15 | Control of Mergers and Acquisition, Its Impact on the Market Development in Albania显示文摘 | Servete Gruda Brilanda Bushati Albana Dibra | 2012 | Journal of US-China Public Administration2012，9，3： | 2 |
| 16 | CaCl_2-Cu_2S-NiS熔盐电解生产Cu-Ni合金(英文)显示文摘介绍一种金属/合金的生产方法,用于恒电流和恒电位条件下由混合硫化物(Cu_2S,NiS)生产Cu-Ni合金,称为直接电化学还原(DER)。研究槽电压和槽电流等工艺参数对还原得到的化合物组成的影响,以生产工业所需的CuNi10, CuNi20和CuNi30等合金。在1200℃下采用循环伏安法(CV)考察Cu_2S和NiS在CaCl2熔体中的电化学行为。根据CV研究结果,Cu_2S的阴极还原是一步完成的,即Cu_2S■Cu; NiS的阴极还原则分两步进行,即NiS■Ni3S2■Ni。恒电流研究表明,在10A电流下电解15min,可制备出最高硫含量为320×10^(-6)的高纯CuNi10合金。扫描电子显微镜以及能量色散X射线能谱和光学发射光谱(OES)测试结果表明,在2.5 V电压下直接电化学还原15 min,可制备出杂质含量低(即硫含量小于60×10^(-6))的所选成分的Cu-Ni合金。 | Levent KARTAL Servet TIMUR | 2018 | Transactions of Nonferrous Metals Society of China2018，28，10： | 2 |
| 17 | Corrosion behavior of tempered dual-phase steel embedded in concrete显示文摘Dual-phase(DP) steels with different martensite contents were obtained by appropriate heat treatment of an SAE1010 structural carbon steel,which was cheap and widely used in the construction industry. The corrosion behavior of DP steels in con-crete was investigated under various tempering conditions. Intercritical annealing heat treatment was applied to the reinforcing steel to obtain DP steels with different contents of martensite. These DP steels were tempered at 200,300,and 400°C for 45 min and then cooled to room temperature. Corrosion experiments were conducted in two stages. In the first stage,the corrosion potential of DP steels embedded in concrete was measured every day for a period of 30 d based on the ASTM C 876 standard. In the second stage,the anodic and cathodic polarization values of these steels were obtained and subsequently the corrosion currents were determined with the aid of cathodic polarization curves. It was observed that the amount of second phase had a definite effect on the corrosion behavior of the DP steel embedded in concrete. As a result of this study,it is found that the corrosion rate of the DP steel increases with an increase in the amount of martensite. | Oguzhan Kelestemur Mustafa Aksoy Servet Ylldlz | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，1： | 2 |
| 18 | Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease显示文摘 | Altan Onat Günay Can Ender ?rnek Servet Altay Murat Yüksel Evin Ademo?lu | 2013 | Clinical Rheumatology2013，，： | 1 |
| 19 | Body composition,insulin,and leptin levels in patients with ankylosing spoodylitis显示文摘 | Ismail Sail Tevfik Demir Leyla Didem Kozaci Servet Akar Tulay Kayak Merih Birlik | 2007 | Clin Rheumatol2007，26，： | 1 |
| 20 | The behavior of organic components in copper recovery from electroless plating bath effluents using 3D electrode systems显示文摘 | G?khan Orhan Sebahattin Gürmen Servet Timur | 2004 | Journal of Hazardous Materials2004，，3： | 1 |
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