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| 1 | Triterpenoid of avocado (Persea americana) seed and its cytotoxic activity toward breast MCF-7 and liver HepG2 cancer cells显示文摘Objective:To determine the structure of triterpenoid isolated from avocado seeds and the cytotoxic effect on MCF-7 and Hep G2 cells.Methods:The powder sample was macerated with ethanol,followed with separation of the extract by column chromatography.The target compound was monitored on thin layer chromatography plate and reagent Lieberman–Buchard.The isolated compound was characterized by spectral analysis,mainly ultraviolet,infrared,and liquid chromatographymass spectroscopy and their spectroscopic data with those reported in literature were compared.In vitro cytotoxic activity was investigated against Vero,MCF-7,and Hep G2 cell lines using MTT assay.Results:A triterpenoid compound was isolated from ethanol extract.The extracts,fraction(F3),and the isolated compound showed a significant cytotoxic activity against all investigated cell lines.MTT assay showed that the triterpenoid isolate inhibited cell proliferation of MCF-7 and Hep G2 cell line with the IC50 values of 62 mg/m L and 12 mg/m L,respectively,and was safe to normal cells.Conclusions:The results of the present study reveal that triterpenoid from avocado seeds have the potential for further development as anticancer agents. | Andi Nur Fitriani Abubakar Suminar Setiati Achmadi Irma Herawati Suparto | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，5： | 3 |
| 2 | Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections显示文摘 | Mairuhu AT Peri G Setiati TE | 2005 | J Med Vi- rol2005，76，4： | 1 |
| 3 | The association between vitamin D deficiency and type 2 diabetes mellitus in elderly patients 显示文摘 | Hidayat R Setiati S Soewondo P | 2010 | Acta Med Indones2010，42，3： | 1 |
| 4 | The association between vitaminD deficiency and type 2 diabetes mellitus in elderly patients显示文摘 | Hidayat R Setiati S Soewondo P | 2010 | ActaMed Indones2010，42，3： | 1 |
| 5 | The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome显示文摘 | Suharti C Gorp E C Setiati T E | 2002 | Thromb Haemost2002，87，1： | 1 |
| 6 | The role of cytokines in activation of coagulation and fibrindysis in dengue syndrome显示文摘 | SUHARTI C SETIATI T E VAN CORP E C | 2002 | Thromb Haemost2002，87，1： | 1 |
| 7 | RNA secondary structures in the proximal 3′UTR of Indonesian Dengue 1 virus strains显示文摘 | Penelope Koraka Marisol M. Williams Kis Djamiatun Tatty E. Setiati F.H.D van Batenburg Koert J. Stittelaar Albert D.M.E. Osterhaus Byron E.E. Martina | 2009 | Virus Research2009，，1： | 1 |
| 8 | Vitamin D and autoim- mune disease显示文摘 | Ginanjar E Sumariyono Setiati S et aI | 2007 | Acta Med Indones2007，39，2： | 1 |
| 9 | The role of cytokines in activation of coagulation and fibrindysis in dengue syndrome显示文摘 | Suharti C van Gorp EC Setiati TE | 2002 | Thromb Haemost2002，87，1： | 1 |
| 10 | The role of cytokines in activation of coagulation and fibrinolysis in dengae shock syndrome显示文摘 | Suhartic C van Gorp EC Setiati TE | 2002 | Thromb Hacmost2002，87，1： | 1 |
| 11 | The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome显示文摘 | Suharti C van Gorp E C Setiati T E | 2002 | Thromb Haemost2002，87，1： | 1 |
| 12 | The association between vitamin D deficiency and type 2 diabetes mellitus in elderly patients显示文摘 | Hidayat R Setiati S Soewondo P | 2010 | Acta Med Indones2010，42，3： | 1 |
| 13 | Writing for seientific medical manuscript:a guide for preparing manuscript submitted to biomedical journals显示文摘 | Harimurti k | 2007 | Acta Med Indones2007，39，1： | 1 |
| 14 | Elevation of soluble VCAM-1 plasma levels in children with acute dengue virus infection of varying severity显示文摘 | Koraka P Murgue B Deparis X Van Gorp E C Setiati T E Osterhaus A D | 2004 | J Med Virol2004，72，： | 1 |
| 15 | The correlation between body fat distribution and insulin resistance in elderly 显示文摘 | DWIMARTUTIE N SETIATI S OEMARDI M | 2010 | Acta Med Indones2010，42，2： | 1 |
| 16 | Increased PAl-1 plasma levels and risk of death from dengue: no association with the 4G/ 5G promoter polymorphism显示文摘 | Mairuhu AT Setiati TE Koraka P | 2005 | Thromb J2005，3，： | 1 |
| 17 | Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection显示文摘 | Suharti C Setiati TE | 2001 | J Clin Microbiol2001，39，12： | 1 |
| 18 | Kinetics of denguevirusspecific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection 显示文摘 | Koraka P Suharti C Setiati TE | 2001 | J Clin Microbiol2001，39，： | 1 |
| 19 | Vitamin D and autoimmune dis- ease 显示文摘 | Ginanjar E Sumariyono Setiati S | 2007 | Acta Med lndones2007，39，3： | 1 |
| 20 | The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome 显示文摘 | Suharti C van Gorp EC Setiati TE | 2002 | Thromb Haemost2002，87，1： | 1 |
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