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| 1 | Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation显示文摘Macrophage migration inhibitory factor(MIF)is a chemokine that plays an essential role in immune system function.Previous studies suggested that MIF protects neurons in ischemic conditions.However,few studies are reported on the role of MIF in neurological recovery after ischemic stroke.The purpose of this study is to identify the molecular mechanism of neuroprotection mediated by MIF.Human neuroblastoma cells were incubated in Dulbecco’s modified Eagle’s medium under oxygen-glucose deprivation(OGD)for 4 hours and then returned to normal aerobic environment for reperfusion(OGD/R).30 ng/mL MIF recombinant(30 ng/mL)or ISO-1(MIF antagonist;50μM)was administered to human neuroblastoma cells.Then cell cultures were assigned to one of four groups:control,OGD/R,OGD/R with MIF,OGD/R with ISO-1.Cell viability was analyzed using WST-1 assay.Expression levels of brain-derived neurotrophic factor(BDNF),microtubule-associated protein 2(MAP2),Caspase-3,Bcl2,and Bax were detected by western blot assay and immunocytochemistry in each group to measure apoptotic activity.WST-1 assay results revealed that compared to the OGD/R group,cell survival rate was significantly higher in the OGD/R with MIF group and lower in the OGD/R with ISO-1 group.Western blot assay and immunocytochemistry results revealed that expression levels of BDNF,Bcl2,and MAP2 were significantly higher,and expression levels of Caspase-3 and Bax were significantly lower in the MIF group than in the OGD/R group.Expression levels of BDNF,Bcl2,and MAP2 were significantly lower,and expression levels of Caspase-3 and Bax were significantly higher in the ISO-1 group than in the OGD/R group.MIF administration promoted neuronal cell survival and induced high expression levels of BDNF,MAP2,and Bcl2(anti-apoptosis)and low expression levels of Caspase-3 and Bax(pro-apoptosis)in an OGD/R model.These results suggest that MIF administration is effective for inducing expression of BDNF and leads to neuroprotection of neuronal cells against hypoxic injury. | Su Hwan Bae Mi Ran Yoo Ye Yeong Kim In Kyung Hong Mi Hee Kim Seung Hak Lee Dae Yul Kim | 2020 | Neural Regeneration Research2020，15，8： | 11 |
| 2 | Durability of viral response after off-treatment in HBeAg positive chronic hepatitis B显示文摘AIM:To evaluate the durability in hepatitis B e antigen (HBeAg) positive chronic hepatitis B patients who discontinued antiviral treatment. METHODS:A total of 48 HBeAg positive chronic hepatitis B patients who were administered nucleoside analogues and maintained virological response for ≥ 6 mo [hepatitis B virus (HBV) DNA < 300 copies/mL and HBeAg seroconversion] before cessation of treatment were enrolled between February 2007 and January 2010. The criteria for the cessation of the antiviral treatment were defined as follows:(1) achievement of virological response; and (2) duration of consolidation therapy (≥ 6 mo). After treatment cessation, the patients were followed up at 3-6 mo intervals. The primary endpoint was serologic and virologic recurrence rates after withdrawal of antiviral treatment. Serologic recurrence was defined as reappearance of HBeAg positivity after HBeAg seroconversion. Virologic recurrence was defined as an increase in HBV-DNA level > 104 copies/mL after HBeAg seroconversion with previously undetectable HBV-DNA level. RESULTS:During the median follow-up period of 18.2 mo (range:5.1-47.5 mo) after cessation of antiviral treatment, the cumulative serological recurrence rate was 15 % at 12 mo. The median duration between the cessation of antiviral treatment and serologic recurrence was 7.2 mo (range:1.2-10.9 mo). Of the 48 patients with HBeAg positive chronic hepatitis, 20 (41.6%) showed virological recurrence. The cumulative virologic recurrence rates at 12 mo after discontinuing the antiviral agent were 41%. The median duration between off-treatment and virologic recurrence was 7.6 mo (range:4.3-27.1 mo). The mean age of the virological recurrence group was older than that of the non-recurrence group (46.7 ± 12.1 years vs 38.8 ± 12.7 years, respectively; P = 0.022). Age (> 40 years) and the duration of consolidation treatment (≥ 15 mo) were significant predictive factors for offtreatment durability in the multivariate analysis [P = 0.049, relative risk (RR) 0.31, 95% CI (0.096-0.998) and P = 0.005, RR 11.29, 95% CI (2.054-65.12), respectively]. Patients with age (≤ 40 years) who received consolidation treatment (≥ 15 mo) significantly showed durability in HBeAg positive chronic hepatitis B patients (P = 0.014). These results suggest that additional treatment for more than 15 mo after HBeAg seroconversion in patients who are ≤ 40 years old may be beneficial in providing a sustained virological response. CONCLUSION:Our data suggest that HBeAg seroconversion is an imperfect end point in antiviral treatment. Long-term consolidation treatment (≥ 15 mo) in younger patients is important for producing better prognosis in HBeAg positive chronic hepatitis B. | Myeong Jun Song Do Seon Song Hee Yeon Kim Sun Hong Yoo Si Hyun Bae Jong Young Choi Seung Kew Yoon Yong-Han Paik June Sung Lee Hyun Woong Lee Hyung Joon Kim | 2012 | World Journal of Gastroenterology2012，18，43： | 7 |
| 3 | Memory-centric neuromorphic computing for unstructured data processing显示文摘The unstructured data such as visual information,natural language,and human behaviors opens up a wide array of opportunities in the field of artificial intelligence(Al).The memory-centric neuromorphic computing(MNC)has been proposed for the efficient processing of unstructured data,bypassing the von Neumann bottleneck of current computing architecture.The development of MNC would provide massively parallel processing of unstructured data,realizing the cognitive Al in edge and wearable systems.In this review,recent advances in memory-centric neuromorphic devices are discussed in terms of emerging nonvolatile memories,volatile switches,synaptic plasticity,neuronal models,and memristive neural network. | Sang Hyun Sung Tae Jin Kim Hera Shin Hoon Namkung Tae Hong Im Hee Seung Wang Keon Jae Lee | 2021 | Nano Research2021，14，9： | 3 |
| 4 | Saeng-Kankunbi-Tang(生肝健脾汤) Protects Liver against Oxidative Damage through Activation of ERK/Nrf2 Pathway显示文摘Objective: To investigate the cytoprotective effects of Saeng-kankunbi-tang(生肝健脾汤, SKT), a herbal prescription consisting of Artemisia capillaris and Alisma canaliculatum, and its underlying mechanism involved. Methods: In mice, blood biochemistry and histopathology were assessed in carbon tetrachloride(CCl4)-induced oxidative hepatic injury in vivo. The animal groups included vehicle-treated control, CCl4, SKT 500 mg/(kg·day) CCl4+SKT 200 or 500 mg/(kg·day). In Hep G2 cell, tert-butyl hydroperoxide(t BHP) induced severe oxidative stress and mitochondrial dysfunction in vitro. The cyto-protective effects of SKT were determined by 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide(MTT) assay, fluorescence activated cell sorting analysis and western blotting. Results: The administration of SKT prevented liver damage induced by CCl4 in mice, by inhibition of hepatocyte degeneration and inflammatory cell infiltration as well as plasma parameters such as alanine aminotransferase(P<0.01). Moreover, treatment with t BHP induced hepatocyte death and cellular reactive oxygen species production in hepatocyte cell line. However, SKT pretreatment(30–300 μg/m L) reduced this cell death and oxidative stress(P<0.01). More importantly, SKT inhibited the ability of t BHP to induce changes in mitochondrial membrane transition in cell stained with rhodamine 123(P<0.01). Furthermore, treatment with SKT induced extracellular signal-regulated kinases-mediated nuclear factor erythroid-2-related factor 2(Nrf2) activation as well as the expressions of heme oxygenase 1 and glutamate-cystein ligase catalytic, Nrf2 target genes. Conclusion: SKT has the ability to protect hepatocyte against oxidative stress and mitochondrial damage mediated by Nrf2 activation. | In Woo Lee Hee Yoon Choi Ju-Hee Lee Sun-Dong Park Seung Mo Kim Sae Kwang Ku 赵容杰 Sang Chan Kim Young Woo Kim Hong Sik Choi | 2016 | Chinese Journal of Integrative Medicine2016，22，8： | 3 |
| 5 | Prognosis of ocular myasthenia in Korea: A retrospective multicenter analysis of 202 patients显示文摘 | Yoon-Ho Hong Seok-Beom Kwon Byung-Jo Kim Byoung Joon Kim Seung Hyun Kim Jong Kuk Kim Kyung-Seok Park Ki-Jong Park Jung-Joon Sung Eun Hee Sohn Yeong-Bae Lee Dushin Jeong In Soo Joo Byung-Ok Choi Young-Chul Choi | 2008 | Journal of the Neurological Sciences2008，，1： | 2 |
| 6 | Effect of Delayed Transit Time on Arterial Spin Labeling: Correlation With Dynamic Susceptibility Contrast Perfusion Magnetic Resonance in Moyamoya Disease显示文摘 | Tae Jin Yun Chul-Ho Sohn Moon Hee Han Hyun-Seung Kang Jeong Eun Kim Byung-Woo Yoon Jin Chul Paeng Seung Hong Choi Ji-hoon Kim In Chan Song Kee-Hyun Chang | 2013 | Investigative Radiology2013，，11： | 1 |
| 7 | Lymph node metastasis: ultrasmall superparamagnetic iron oxlde-enhancod MR imaging versus PEF/CT in a rabbit model显示文摘 | Seung Hong Choi Woo Kyung Moon Ju Hee Hong | | Radiology0，242，： | 1 |
| 8 | Chemical composition of precipitation and wet deposition of major ions on the Korean peninsula显示文摘 | Bo Kyoung Lee Seung Hee Hong Dong Soo Lee | 1999 | Atmospheric Environment1999，，4： | 1 |
| 9 | Chemical composition of precipitation and wet deposition of major ions on the Korean peninsula显示文摘 | LeeBo kyong Hong Seung hee Lee Dong soo | 2000 | Atmospheric Environment2000，34，： | 1 |
| 10 | Modified selected mapping technique for PAPR reduction of coded OFDM signal 显示文摘 | Han Seung Hee Lee Jae Hong | 2004 | IEEE Transactions on Broadcasting2004，50，3： | 1 |
| 11 | Iron overload accelerates bone loss in healthy postmenopausal women and middle‐aged men: A 3‐year retrospective longitudinal study显示文摘 | Beom‐Jun Kim Seong Hee Ahn Sung Jin Bae Eun Hee Kim Seung‐Hun Lee Hong‐Kyu Kim Jae Won Choe Jung‐Min Koh Ghi Su Kim | 2012 | J Bone Miner Res2012，，： | 1 |
| 12 | An Overview of Peak-to-Average Power Ratio Reduction Techniques for Multicarrier Transmission显示文摘 | Han Seung Hee Lee Jae Hong | 2005 | IEEE Wireless Communications2005，12，2： | 1 |
| 13 | Modified Selected Mapping Technique for PAPR Reduction of Coded OFDM Signal显示文摘 | Seung Hee Han Jae Hong Lee | 2004 | IEEE Transactions on Broadcasting2004，50，3： | 1 |
| 14 | An Overview of Peak-to-Average Power Ratio Reduction Techniques for Muhicarrier Transmission 显示文摘 | Seung Hee Han Jae Hong Lee | 2005 | IEEE Wireless Communications2005，4，： | 1 |
| 15 | An Overview of Peakto-Average Power Ratio Reduction Techniques for Multicarrier Transmission显示文摘 | Seung Hee Han Jae Hong Lee | 2005 | IEEE Wireless Communications2005，，4： | 1 |
| 16 | Modified Seleeted Mapping Technique for PAPR Reduetion of Coded OFDM Signal 显示文摘 | Seung Hee Han Jae Hong Lee | 1998 | IEEE Transactionson Broadeasting1998，50，3： | 1 |
| 17 | An overview of peak-to-average power ratio reduction techniques for muhicarrier transmission显示文摘 | Seung Hee Han Jae Hong Lee | 2005 | Electronics Letters2005，12，2： | 1 |
| 18 | An overview of peak - to - average power ratio reduction techniques for muhicartier transmission 显示文摘 | Seung Hee HAN and Jae Hong Lee | 2005 | IEEE Transactions on Wireless Communications2005，12，2： | 1 |
| 19 | PAPR Reduction of OFDM signals using a reduced complexity PTS technique 显示文摘 | Seung Hee Han Jae Hong Lee | 2004 | IEEE signal processing Letters2004，11，11： | 1 |
| 20 | Modified selected mapping technique for PAPR reduction of ceded OFDM signal 显示文摘 | Seung Hee Han Jae Hong Lee | 2004 | IEEE Transactions2004，3，50： | 1 |
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