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| 1 | Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver显示文摘AIM:To explore lipocalin-2(LCN-2)expression and its possible role and mechanism(s)of production in rat models of diet-inducible fatty liver.METHODS:Fatty liver was triggered in male SpragueDawley rats fed either with liquid Lieber-DeCarli(LDC)or LDC+70%cal fructose(L-HFr)diet for 4 or 8 wk.Chow-nourished animals served as controls.Hepatic expression of LCN-2 and other metabolic and inflammatory mediators was assessed by quantitative reverse transcription polymerase chain reaction and Western blotting.Serum LCN-2,fasting leptin,and lipid profile were evaluated via Enzyme-Linked Immunosorbent Assay,Radioimmunoassay,and colorimetric assays,respectively.The localization of LCN-2 in the liver was detected by using immunofluorescence staining.Furthermore,HE stain was used to evaluate hepatic fatdegeneration and inflammation.RESULTS:Both LDC-fed and L-HFr-fed rat histologically featured fatty liver.In the liver,mRNA transcriptions of Mcp-1,a2-m,Il-8 and Glut5 were increased in the L-HFr group at both time points(P<0.001),while the transcription of Tlr4,Inos,and Tnf-a was significantly up-regulated at week 4.Interestingly,hepatic Lcn-2 expression was 90-fold at week 4 and 507-fold at week 8 higher in L-HFr-subjected rats vs control(P<0.001).In contrast to HDL-cholesterol,systemic levels of LCN-2,fasting leptin and triglycerides were elevated in the L-HFr regimen(P<0.001).Moreover,protein expression of hepatic LCN-2,CD14,phosphoMAPK,caspase-9,cytochrome c and 4-hydroxynonenal was increased in the L-HFr group.Conversely,the hepatic expression of PGC-1a(a mitochondrial-biogenic protein)was reduced in the L-HFr category at week 8.The localization of LCN-2 in the liver was predominantly restricted to MPO+granulocytes.CONCLUSION:Fructose diet up-regulates hepatic LCN-2 expression,which correlates with the increased indicators of oxidative stress and mitochondrial dysfunction.The LCN-2 may be involved in liver protection. | Salamah Mohammad Alwahsh Min Xu Hatice Ali Seyhan Shakil Ahmad Sabine Mihm Giuliano Ramadori Frank Christian Schultze | 2014 | World Journal of Gastroenterology2014，20，7： | 7 |
| 2 | Comparison of corneal endothelial changes following phacoemulsification with transversal and torsional phacoemulsification machines显示文摘AIM:To compare and evaluate the phacoemulsification parameters and postoperative endothelial cell changes of two different phacoemulsification machines, each with different modes, but also to assess the relationship between postoperative endothelial cell loss and the phacoemulsification parameters, as well as the other factors in both groups.METHODS:This prospective observational study was comprised of consecutive eligible cataract patients operated with phacoemulsification technique performed by the same surgeon using either a WHITESTAR Signature Ellips FX(transversal, group 1) or Infiniti OZil IP(torsional, group 2) machine.RESULTS:The study included 86 patients. Baseline characteristics in the groups were similar. The median nuclear sclerosis grade was 3(2-4) in the first group and2(2-4) in the second group(P =0.265). Both groups had similar phacoemulsification needle times(group 1: 60.63±36 s; group 2: 55.98±30 s; P =0.789). The percentage of endothelial cell loss 30 d after surgery ranged from 3% to15% with a median of 7% in group 1, and from 2% to13% with a median of 6% in group 2; however, there was no statistically significant difference between the groups(P =0.407). Hexagonality(P =0.794) and the coefficient of variation(CV; P =0.142) did not differ significantly between the groups before and 30 d after surgery. Asignificant positive correlation was found between the endothelial cell loss and nuclear sclerosis grade(group1: P <0.001; group 2: P <0.001) and between the endothelial cell loss and average phacoemulsification power(group 1: P =0.007; group 2: P =0.008).CONCLUSION:Both of these machines were efficient,with similar endothelial cell loss. This endothelial cell loss was related to the increased nuclear sclerosis grade and increased phacoemulsification power. | Mustafa Atas Süleyman Demircan Arzu Seyhan Karatepe Hashas Ahmet Gülhan Gkmen Zararsιz | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 7 |
| 3 | Phenolic compounds affect production of pyocyanin, swarming motility and biofilm formation of Pseudomonas aeruginosa显示文摘Objective: To investigate the effects of plant-derived phenolic compounds(i.e. caffeic acid, cinnamic acid, ferulic acid and vanillic acid) on the production of quorum sensing regulated virulence factors such as pyocyanin, biofilm formation and swarming motility of Pseudomonas aeruginosa(P. aeruginosa) isolates.Methods: Fourteen clinical P. aeruginosa isolates obtained from urine samples and P. aeruginosa PA01 strain were included in the study. The antibacterial effects of phenolic compounds were screened by well diffusion assay. Pyocyanin and biofilm activity were measured from culture supernatants and the absorbance values were measured using a spectrophotometer. Swarming plates supplemented with phenolic acids were point inoculated with P. aeruginosa strains and the ability to swarm was determined by measuring the distance of swarming from the central inoculation site.Results: Tested phenolic compounds reduced the production of pyocyanin and biofilm formation without affecting growth compared to untreated cultures. Moreover, these compounds blocked about 50% of biofilm production and swarming motility in P. aeruginosa isolates.Conclusions: We may suggest that if swarming and consecutive biofilm formation could be inhibited by the natural products as shown in our study, the bacteria could not attach to the surfaces and produce chronic infections. Antimicrobials and natural products could be combined and the dosage of antimicrobials could be reduced to overcome antimicrobial resistance and drug side effects. | Aylin Ugurlu Aysegul Karahasan Yagci Seyhan Ulusoy Burak Aksu Gulgun Bosgelmez-Tinaz | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，8： | 3 |
| 4 | 蒸汽箱技术的创新显示文摘随着技术的不断发展进步,设计产生了新一代蒸汽箱。与传统的蒸汽箱相比,新一代蒸汽箱几乎拥有2倍的热传递效率,同时减少了蒸汽消耗,拥有更高的可靠性和更好的横幅调节能力。文中重点介绍了新一代蒸汽箱的设计,并通过示例阐述了新技术有助于降低蒸汽箱总成本,同时又显著提高性能。 | Ankur Gupta Seyhan Nuyan 竺宁 张见风 | 2008 | 国际造纸2008，27，4： | 2 |
| 5 | Prognostic Significance of ERCC1 Expression in Resected Non Small Cell Lung Carcinoma显示文摘 | Seyhan EC Altin S Cetinkaya E | 2011 | Ann Thorac Cardiovasc Surg2011，17，2： | 1 |
| 6 | Red blood cell distribution and survival in patients with chronic obstructive pulmonary disease显示文摘 | Seyhan EC Ozgul MA Tutar N | 2013 | COPD2013，10，4： | 1 |
| 7 | Effects of three dif-ferent dose regimens of magnesium on propofol requirements,haemodynamic variables and postoperative pain relief in gynecological surgery显示文摘 | Seyhan TO Tugrul M Sungur MO | 2006 | Br J Anaesth2006，96，2： | 1 |
| 8 | Evaluation of occupational injuries with lost days among opencast coal mine workers through lo- gistic regression models 显示文摘 | Seyhan Onder | 2013 | Safety Science2013，，59： | 1 |
| 9 | High dose eabergolinein management of ovarian hyperstimulation syndrome 显示文摘 | Ata B Seyhan A Orhaner S | 2009 | Fertil Steril2009，5，： | 1 |
| 10 | 'Reading man flap' design for recon- struction of circular infraorbital and malar skin defects 显示文摘 | Seyhan T Caglar B | 2008 | Dermatol Surg2008，34，11： | 1 |
| 11 | 900MHz pulse-modulated radiofrequency radiation induces oxidative stress on heart, lung, testis and liver tissues 显示文摘 | Esmekaya MA Ozer C Seyhan N | 2011 | Gen Physiol Biophys2011，30，1： | 1 |
| 12 | Correction of major saddle nose deformitics with nasomaxillary depression using an intraoral and external open rhinoplasty approach显示文摘 | SEYHAN T | 2010 | Aesthetic Plast Surg2010，10，： | 1 |
| 13 | Tocopherol, carotene, phenolic contents and antibacterial properties of rose essential oil, hydrosol and absolute显示文摘 | Seyhan Ulusoy Gtlgfm Bosgelmez-Tmaz Hale Segilmis- Canbay | 2009 | Curt Microbiol2009，，59： | 1 |
| 14 | Improved endothelium dependent vasodilation in endurance athletes and its relation with ACE I/D polymorphism显示文摘 | HALIL TANRIVERDI HARUN EVRENGUL SEYHAN TANRIVERDI | 2005 | Circ J2005，69，： | 1 |
| 15 | Mobile phone radiation- induced fl'ee radical damage ill lhe liver is inhibited by lhe antioxidanls n-acelyl cysleine and epigalleatechin- gallate显示文摘 | Ozgur E Guler G Seyhan N | 2010 | International Journal of Radiation Biology2010，86，11： | 1 |
| 16 | Red blood cell distribution and survival in patients with chronic obstructive pulmonary disease显示文摘 | Seyhan EQOzguI MA Tutar N | 2013 | COPD2013，10，4： | 1 |
| 17 | Effects of three different dose regimens of magnesium on propofol require- ments,haemodynamic variables and postoperative pain re- lief in gynaecological surgery显示文摘 | Seyhan TO Tuqrul M Sunqur MO et a/ | 2006 | Br J Anaesth2006，96，2： | 1 |
| 18 | Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women显示文摘 | Ozlem Kurt Hulya Yilmaz-Aydogan Mehmet Uyar Turgay Isbir Mehmet Seyhan Ayse Can | 2012 | Molecular Biology Reports2012，，6： | 1 |
| 19 | Critical aspects related to processing of carbon nanotube/unsaturated thermoset polyester nanocomposites显示文摘 | Tugrul Seyhan Florian H Gojny Metin Tanoglu | 2007 | Europoan Polymer Journal2007，43，2： | 1 |
| 20 | The effect of gastric Helicobacter pylori eradication on recurrent aphthous stomatitis显示文摘 | Semsettin Karaca Muammer Seyhan Mustafa Senol | 2008 | International Journal of Dermatology2008，47，： | 1 |
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