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| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | Effects of partial portal vein arterialization on the hilar bile duct in a rat model显示文摘BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P<0.01). No apoptotic hilar bile duct epithelial cells were detected in any of the groups. The PBP arteriolar counts of the hilar bile duc wall were similar in groups A and C (P>0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation. | Shao-Hua Guo, Chong-Hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (Guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo SH), General Hospital of PLA, Beijing 100853, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 8 |
| 3 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 4 | Transformation of a texas cotton cultivar by using agrobacterium and the shoot apex显示文摘 | Zapata C Park SH EI-Zik KM | 1999 | Theor Appl Genet1999，98，92： | 2 |
| 5 | An innovative pirani pressure sensor显示文摘 | CHOU C S SHIE J SH | 1997 | IEEE1997，，： | 2 |
| 6 | Advanced glycation end products induce apoptosis and procoagulant activity in cultured human umbilical vein endothelial cells显示文摘 | Kang E Yu SH | 1999 | Diabetes Res Clin Pract1999，46，3： | 1 |
| 7 | Perioperative glycemic control and the risk of infectious complications in a cohort of adults with diabetes显示文摘 | Peart-Vigilance C Kao WHL | 1999 | Diabetes Care1999，22，9： | 1 |
| 8 | Enhancing hypertension awareness and management in the elderly: lessons learned from the Airdrie Community Hypertension Awareness and Management Program (A-CHAMP) 显示文摘 | Jones C Simpson SH Mitchell D | 2008 | Can J Cardiol2008，24，7： | 1 |
| 9 | A comparison of the minimental state exam to the Montreal cognitive assessment in identifying cognitive deficits in Parkinsonps disease显示文摘 | Zadikoff C Fox SH Tang2Wai DF | 2008 | Mov Disord2008，23，2： | 1 |
| 10 | The purification of mouse monoclonal antibodies from ascitic fluid显示文摘 | Neoh SH Gordon C Potter A | 1986 | J Immunol Methods1986，91，2： | 1 |
| 11 | Perioperative glycemic control and the risk of infectious complications in a cohort of adults with diabetes 显示文摘 | Golden SH Peart-Vigilance C Kao WH | 1999 | Diabetes care1999，22，9： | 1 |
| 12 | Intrinsic and Extrinsic Motivation in Internet Usage显示文摘 | Teo SH Lim K G Lai Y C | | 0，，27： | 1 |
| 13 | Deterioration of gait and balance over time: the effects of age-related white matter change--The LADIS Study显示文摘 | Kreisel SH Blahak C B | 2013 | Cerebrovasc Dis2013，35，6： | 1 |
| 14 | The extended transverse musculocutaneous gracilis flap vascular anatomy and clinical implications显示文摘 | Wong C Mojallal A Bailey SH | 2011 | Ann Plast Surg2011，67，2： | 1 |
| 15 | The structure of anxiety symptoms among preschoolers显示文摘 | Spence SH Rapee RM Mcdonld C | 2001 | Behaviour Research and Therapy2001，39，11： | 1 |
| 16 | Heterogeneity within the ventricular wall:Electrophysiology and pharmacology of epicardial, endocardial and M cells显示文摘 | Antzelevitch C Sicouri S Litovsky SH | 1991 | Circ Res1991，69，： | 1 |
| 17 | Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation 显示文摘 | Slofstra SH van't Veer C Buurman WA | 2005 | Crit Care Med2005，33，6： | 1 |
| 18 | Perioperative glycemic control and the risk of infectious complications in a cohort of adults with diabetes显示文摘 | Golden SH Peart-Vigilance C | 1999 | Diabetes Care1999，22，： | 1 |
| 19 | The effect of murine depletion by beta - alanine treatment on the susceptibility to ethanol - induced hepatic dysfunction in rats显示文摘 | Waterfield C J Kenyon SH | 2001 | Alcohol2001，36，： | 1 |
| 20 | Qualitative and quantitative determination of the major coumarins in Zushima by high performance liquid chrom atography with diode array detector and mass spectrometry 显示文摘 | SU J ZHANG C ZHANG W SH EN Y H LIH H LIU R H ZHANG X HU X J ZHANG W D | 2009 | J Chromatogr: A2009，1216，11： | 1 |
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