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| 1 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 2 | Mechanisms of fibrinolysis resistance and potential targets for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli显示文摘There has been growing interest and insight into the histological composition of retrieved stroke emboli.One of the main focuses of the stroke clot analysis literature has been the implications of clot composition on mechanical thrombectomy procedures.However,the holy grail of clot analysis may not be in the field of clot-device interaction,but rather,in understanding mechanisms of fibrinolysis resistance.The mechanisms underlying the low response to fibrinolytic therapy,even with the newer,more powerful agents,remain poorly understood.While factors such as embolus size,location and collateral status influence alteplase delivery and recanalisation rates;compositional analyses focused on histological and ultrastructural characteristics offer unique insights into mechanisms of alteplase resistance.In this review,we strive to provide comprehensive review of current knowledge on clot composition and ultrastructural analyses that help explain resistance to fibrinolysis. | Waleed Brinjikji Oana Madalina Mereuta Daying Dai David F Kallmes Luis Savastano Yang Liu Shahid M Nimjee Raul G Nogueira Mehdi Abbasi Ramanathan Kadirvel | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 3 | 起作用的术语和手术后的管理途径适用于肝的外科: 受训练者观点显示文摘 Outcomes in hepatic resectional surgery(HRS) have improved as a result of advances in the understanding of hepatic anatomy,improved surgical techniques, and enhanced peri-operative management.Patients are generally cared for in specialist higher-level ward settings with multidisciplinary input during the initial post-operative period,however,greater acceptance and understanding of HRS has meant that care is transferred,usually after 24-48 h,to a standard ward environment.Surgical trainees will be presented with such patients either electively as part of a hepatobiliary firm or whilst covering the service on-call,and it is therefore important to acknowledge the key points in managing HRS patients.Understanding the applied anatomy of the liver is the key to determining the extent of resection to be undertaken.Increasingly,enhanced patient pathways exist in the post-operative setting requiring focus on the delivery of high quality analgesia,careful fluid balance,nutrition and thromboprophlaxis.Complications can occur including liver,renal and respiratory failure,hemorrhage,and sepsis,all of which require prompt recognition and management.We provide an overview of the relevant terminology applied to hepatic surgery,an approach to the post-operative management,and an aid to developing an awareness of complications so as to facilitate better confidence in this complex subgroup of general surgical patients. | Shahid G Farid K Rajendra Prasad Gareth Morris-Stiff | 2013 | World Journal of Gastrointestinal Surgery2013，5，5： | 2 |
| 4 | Study of serum homocysteine, folic acid and vitamin B (12) in patients with preeclampsia显示文摘 | Shahid A Mujawar Vinayak W Patil Rekha G Daver | 2011 | Indian journal of clin- ical biochemistry : IJC B2011，26，3： | 1 |
| 5 | Nitro- and aminophenols as corrosion inhibitors for aluminium and zinc pigments 显示文摘 | Muller B Shahid M Kinet G | 1999 | Corrosion Science1999，41，： | 1 |
| 6 | Axial length in apparently normal pediatric eyes显示文摘 | Hussain RN Shahid F Woodruff G | 2014 | Eur J Ophthalmol2014，24，1： | 1 |
| 7 | Axial length in apparently normal pediatric eyes显示文摘 | Hussain RN Shahid F Woodruff G | 2014 | Eur J Ophthalmol2014，24，1： | 1 |
| 8 | Primary user behavior aware spectrum allocation scheme for cognitive radio networks显示文摘 | Aslam S Shahid A Lee K G | 2014 | Computers and Electrical Engineering2014，，： | 1 |
| 9 | Chemically functiona lized alumina nanoparticle effect on carbon fiber/ epoxy composites 显示文摘 | SHAHID N VILLATE R G BARRON A R | 2005 | Composites Science and Technology2005，65，14： | 1 |
| 10 | EDTA-enhanced phytor-emediation of heavy metals:A review显示文摘 | Shahid M Austruy A Echevarria G | 2014 | Soil and Sediment Contamination2014，23，4： | 1 |
| 11 | Nitro- and aminophenols as corrosion inhibitors for aluminium and zinc pigments 显示文摘 | Muller B Shahid M Kinet G | 1999 | Corrosion Sci1999，41，： | 1 |
| 12 | Nitro-and aminophenols as corrosion inhibitors for aluminium and zinc pigments 显示文摘 | Muller B Shahid M Kinet G | 1999 | Corrosion Sci1999，41，： | 1 |
| 13 | Nitroand aminophenols as corrosion inhibitors for aluminium and zinc pigments 显示文摘 | Muller B Shahid M Kinet G | 1999 | Cocrros Sci1999，41，7： | 1 |
| 14 | Laparoscopic management of a 16-week ruptured rudimentary horn pregnancy:a case and literature review显示文摘 | Shahid A Olowu O Kandasamy G | 2010 | Arch Gynecol Obstet2010，282，2： | 1 |
| 15 | A multi-level quali- tative analysis of telehomecare in Ontario :challenges and op- portunities 显示文摘 | Hunting G Shahid N Sahakyan Y | 2015 | BMC Health Serv Res2015，15，1： | 1 |
| 16 | Analysis of steroidal sapogenins from Amber fenugreek (Trigonella foenum-graecum)by capillary gas chromatography and combined gas chromato-graphy/mass spectrometry显示文摘 | Wesley G Taylor M Shahid Zaman Zahir Mir | 1997 | J Agric Food Chem1997，45，3： | 1 |
| 17 | EDTA-enhanced phytoremediation of heavy metals: A review显示文摘 | Shahid M Austruy A Echevarria G | 2014 | Soil and Sediment Contamination2014，23，4： | 1 |
| 18 | Chemically func- tionalized alumina nanoparticle effect on carbon fiber/epoxy com- posites 显示文摘 | SHAHID N VILLATE R G BARRON A R | 2005 | Composites Science and Technology2005，65，14： | 1 |
| 19 | Chemically functional?ized alumina nanoparticle effect on carbon fiberl epoxy com?posites显示文摘 | Shahid N Villate R G Barron A R | 2005 | Composites Science and Technology2005，65，14： | 1 |
| 20 | Asenapine:a novel psychopharmaeologic agent with a unique human receptor signature 显示文摘 | Shahid M Walker G B Zonl S H | 2009 | J Psychophannacol2009，23，： | 1 |
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