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| 1 | Therapeutic management options for stage Ⅲ non-small cell lung cancer显示文摘Lung cancer is the leading cause of cancer death worldwide.Majority of newly diagnosed lung cancers are non-small cell lung cancer(NSCLC), of which up to half are considered locally advanced at the time of diagnosis.Patients with locally advanced stage Ⅲ NSCLC consists of a heterogeneous population, making management for these patients complex.Surgery has long been the preferred local treatment for patients with resectable disease.For select patients, multimodality therapy involving systemic and radiation therapies in addition to surgery improves treatment outcomes compared to surgery alone.For patients with unresectable disease, concurrent chemoradiation is the preferred treatment.More recently, research into different chemotherapy agents, targeted therapies, radiation fractionation schedules, intensity-modulated radiotherapy, and proton therapy have shown promise to improve treatment outcomes and quality of life.The array of treatment approaches for locally advanced NSCLC is large and constantly evolving.An updated review of past and current literature for the roles of surgery, chemotherapeutic agents, radiation therapy, and targeted therapy for stage Ⅲ NSCLC patients are presented. | Stephanie M Yoon Talha Shaikh Mark Hallman | 2017 | World Journal of Clinical Oncology2017，8，1： | 32 |
| 2 | Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation显示文摘Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury. | Ihab I El Hajj Shahid M Malik Hany R Alwakeel Obaid S Shaikh Eizaburo Sasatomi Hossam M Kandil | 2009 | World Journal of Gastroenterology2009，15，31： | 4 |
| 3 | 不锈钢等离子体性能的激光诱导击穿光谱法研究显示文摘研究了由Nd:YAG激光的一级及二级谐波(SHG)产生的不锈钢等离子体参数的测量方法。根据已知的谱线进行光谱分析,利用Boltzmann法估算出了激发温度,而等离子体的电子密度是从谱线的Stark展宽剖面估算出来的。在常压下研究了等离子体的空间及时间演化过程,结果发现谱线的积分光强及积分宽度随着时间的延迟而降低。除了逆韧致辐射吸收的估算,同时研究了激光辐照度和波长对等离子体参数的影响。 | SHAIKH Nek M KALHORO M S BAIG M A | 2009 | 冶金分析2009，29，7： | 2 |
| 4 | In vivo anticancer activity of vanillin semicarbazone显示文摘Objective:To evaluate the anticancer activity of vanillin semicarbazone(VSC) against Ehrlich ascites carcinoma(EAC) cells in Swiss albino mice.Methods:The compound VSC at three doses(5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight,enhancement of survival time as well as the changes in depleted hematological parameters. Allsuch parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg(i.p.).Results:Among the doses studied, 10 mg/kg(i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg(i.p.). The host toxic effects of VSC was found to be negligible.Conclusions:It can be concluded that VSC can therefore be considered as potent anticancer agent. | Shaikh M Mohsin Ali M Abul Kalam Azad Mele Jesmin Shamim Ahsan M Mijanur Rahman Jahan Ara Khanam M Nazrul Islam Sha M Shahan Shahriar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 5 | Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence显示文摘BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related mortality.Classifying clinical parameters that increase risk for recurrence after IBTR remains a challenge.AIM To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease outcomes.METHODS Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our institution.Overall survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan Meier method.We identified patients who experienced an isolated IBTR.Concordance of hormone receptor status and location of tumor from primary to recurrence was evaluated.The effect of clinical and treatment parameters on disease outcomes was also evaluated.RESULTS We identified 2164 patients who met the eligibility criteria.The median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]years.Five-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 IBTRs.We identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ component.Median time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)years.Radiotherapy information was available for 30 of 37 patients.Median whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor bed.Twenty-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly associated.There were no observed changes in HER-2 status from primary to IBTR.The concordance between quadrant of primary to IBTR was 10/19[(62.2%),P=0.008].Tumor size greater than 1.5 cm(HR=0.44,95%CI:0.22-0.90,P=0.02)and use of endocrine therapy upfront(HR=0.36,95%CI:0.18-0.73,P=0.004)decreased the risk of IBTR.CONCLUSION Among patients with early stage breast cancer who had breast conserving surgery treated with adjuvant RT,ER/PR status and quadrant were highly concordant from primary to IBTR.Tumor size greater than 1.5 cm and use of adjuvant endocrine therapy were significantly associated with decreased risk of IBTR. | Juhi M Purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber | 2020 | World Journal of Clinical Oncology2020，11，1： | 2 |
| 6 | Celiac artery aneurysm em- bolization by coil occlusion 显示文摘 | Syed M Shaikh A Neravetla S | 2005 | Ann Vase Surg2005，19，： | 1 |
| 7 | An OSPF Topology Server: Design and Evalu- ation 显示文摘 | SHAIKH A GOYAL M | 2002 | IEEE Journal on Selected Areas in Communications2002，20，4： | 1 |
| 8 | Binding of trazodone hydrochloride with human serum albumin: A spectroscopic study 显示文摘 | Kandagal P B Seetharamappa J Shaikh S M T | 2007 | J Photochem Photobiol A2007，185，： | 1 |
| 9 | Assessment of stress corrosion crack initiation and propagation in AISI type 316 stainless steel by electrochemical noise technique 显示文摘 | Anita T Pujar M Shaikh H | 2006 | Cor ros Sci2006，48，9： | 1 |
| 10 | Spectroscopic characterization of laser ablation brass plasma显示文摘 | Shaikh N M Hafeez S Kalyar M A | 2008 | J Appl Phys2008，104，10： | 1 |
| 11 | A study of the interaction between bromopyrogallol red and bovine serum albumin by spectroscopic methods显示文摘 | Shaikh S M T Seetharamappa J Ashoka S | 2007 | Dyes and Pigments2007，73，： | 1 |
| 12 | Effect of aging on the hardness and impact properties of Hastclloy C-276显示文摘 | Akhter J I Shaikh M A | 2001 | Journal of Materials Science Letters2001，20，4： | 1 |
| 13 | Utilization of sugarcane bagasseeellulose for producing cellulose acetates: Novel use of residual hemicellulose as plasticizer显示文摘 | Shaikh H M Pandare KV Nair G | 2009 | Carbohydrate polymersm2009，76，1： | 1 |
| 14 | A study on ethosomes as mode for transdermal delivery of an antidiabetic drug显示文摘 | Bodade S S Shaikh K S Kamble M S | 2013 | Drug Deliv2013，20，1： | 1 |
| 15 | theta Isoform of protein ki-nase C alters barrier function in intestinal epithelium through mod-ulation of distinct claudin isotypes:a novel mechanism for regula-tion of permeability显示文摘 | Banan A Zhang LJ Shaikh M | | 0，，03： | 1 |
| 16 | Preparation and characterization of molecularly imprinted polymer for di(2-ethylhexyl) phthalate: Application to sample clean-up prior to gas chromatographic determination显示文摘 | Shaikh H Memon N Khan H Bhanger M I and Nizamani S M | 2012 | Journal of Chromatogrphy A2012，1247，： | 1 |
| 17 | Docosahexaenoic acid affects cell signaling by altering lipid rafts显示文摘 | Stillwell W Shaikh SR Zerouga M Siddiqui R Wassail SR | 2005 | Reprod Nutr Dev2005，45，5： | 1 |
| 18 | A study of the interaction between bromopyrogallol red and bovine serum albumin by spectroscopic methods 显示文摘 | SHAIKH S M T SEETHARAMAPPA J ASHOKA S | 2007 | Journal of Molecular Structure2007，73，2： | 1 |
| 19 | Enzymatic hydrolysis of delignified bagasse polysaccharides 显示文摘 | Adsul M G Ghule J E Shaikh H | 2005 | Carbohydr Polym2005，62，： | 1 |
| 20 | Age, gender, and racial dif- ferences in incidence and survival in primary CNS lymphoma显示文摘 | Villano JL Koshy M Shaikh H | 2011 | BrJ Cancer2011，105，9： | 1 |
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