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| 1 | Effect of cholecystokinin on cytokines during endotoxic shock in rats显示文摘AIM To study the effect of cholecystokinin-octapeptide (CCK-8) on systemic hypotension and cytokine production in lipopolysaccharide (LPS)-induced endotoxic shock (ES) rats.``METHODS The changes of blood pressure were observed using physiological record instrument in four groups of rats: LPS (8 mg. kg-1, iv) induced ES; CCK-8 (40 μg.kg- 1 iv) pretreatment 10 min before LPS (8 mg. kg- 1);CCK-8 (40 μg.kg-1, iv) or normal saline (control) groups.Differences in tissue and circulating specificity of the proinflammatory cytokines (TNF-a, IL-l3 and IL-6) were assayed with ELISA kits.``RESULTS CCK-8 reversed LPS-induced decrease of mean artery blood pressure (MABP) in rats. Compared with control, LPS elevated the serum level of IL-6 significantly (3567_-687 ng.L-1 vs 128_+22 ng.L-1, P<0.01), while contents of TNF-a and IL- lβ elevated significantly (277 _± 86ng.L-1 vs not detectable and 43 ± 9 ng.L-1 vs notdetectable, P<0.01) but less extent than IL-6, CCK-8significantly inhibited the LPS-induced increase in serum TNF-a, IL-lβ and IL-6. LPS elevated spleen and lung content of IL-Iβ significantly (5184 ± 85 ng.L-1 vs 1047 ±21 ng.L-1 and 4050 ± 614 ng.L-1 vs not detectable,P<0,01). while levels of TNF-a and IL-6 also rosesignificantly but in less extent than IL-lβ. CCK-8 inhibited the LPS-induced increase of the cytokines in spleen and lung. in the heart, CCK-8 significantly inhibited LPS.induced increase of TNF-a (864 ± 123 ng. L-1 in CCK-8 +LPS group vs 1599_-227 ng-L-1 in LPS group, P<0.01),and IL-lβ (282 ± 93 ng-L-1 in CCK-8 + LPS group vs 621 ±145 ng.L-1 in LPS group, P<0.01).``CONCLUSION CCK-8 reverses ES, which may be relatedto its inhibitory effect on the overproduction of cytokines. | Yi-Ling Ling~1 Ai-Hong Meng~1 Xiao-Yun Zhao~1 Bao-En Shan~2 Jun-Lan Zhang~1 Xiao-Peng Zhang~3 1 Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China2 Research Center of Fourth Hospital,Hebei Medical University,Shijiazhuang 050000,Hebei Province,China3 Department of Chest Surgery of Hebei Provincial People’s Hospital,Shijiazhuang 050000,Hebei Province,China | 2001 | World Journal of Gastroenterology2001，7，5： | 31 |
| 2 | New development thoughts on the bio-inspired intelligence based control for unmanned combat aerial vehicle显示文摘Bio-inspired intelligence is in the spotlight in the field of international artificial intelligence,and unmanned combat aerial vehicle(UCAV),owing to its potential to perform dangerous,repetitive tasks in remote and hazardous,is very promising for the technological leadership of the nation and essential for improving the security of society.On the basis of introduction of bioinspired intelligence and UCAV,a series of new development thoughts on UCAV control are proposed,including artificial brain based high-level autonomous control for UCAV,swarm intelligence based cooperative control for multiple UCAVs,hy-brid swarm intelligence and Bayesian network based situation assessment under complicated combating environments, bio-inspired hardware based high-level autonomous control for UCAV,and meta-heuristic intelligence based heterogeneous cooperative control for multiple UCAVs and unmanned combat ground vehicles(UCGVs).The exact realization of the proposed new development thoughts can enhance the effectiveness of combat,while provide a series of novel breakthroughs for the intelligence,integration and advancement of future UCAV systems. | DUAN HaiBin 1 ,SHAO Shan 2 ,SU BingWei 3 &ZHANG Lei 41 State Key Laboratory of Science and Technology on Holistic Flight Control,School of Automation Science and Electrical Engineering, Beijing University of Aeronautics and Astronautics,Beijing 100191,China 2 Flight Control Department,Shenyang Aircraft Design and Research Institute,Shenyang 110035,China 3 Beijing Institute of Near Space Vehicle’s System Engineering,Beijing 100076,China 4Integration and Project Section,Air Force Equipment Academy,Beijing 100085,China | 2010 | Science China(Technological Sciences)2010，53，8： | 32 |
| 3 | A novel ubiquitin carboxyl terminal hydroase is involved in toad oocyte maturation显示文摘p28, a 28kD protein from toad (Bufo bufo gargarizans) oocytes, was identified by using p13suc1-agaroseaffinity chromatography. Sequence homology analysis of the full-length cDNA of p28 (Gene Bank accessionnumber: AF 314091) indicated that it encodes a protein containing 224 amino-acids with about 55% iden-tities and more than 70% positives to human, rat or mouse UCH-L1, and contains homological functionaldomains of UCH family. Anti-p28 monoclonal antibody, on injecting into the oocytes, could inhibit theprogesterone-induced resumption of meiotic division in a dose-dependent manner. The recombinant proteinp28 showed similar SDS/PAGE behaviors to the native one, and promoted ubiquitin ethyl ester hydrolysis,a classical catalytic reaction for ubiquitin carboxyl terminai hydrolases (UCHs). The results in this paperreveal that a novel protein, p28, exists in the toad oocytes, is a UCH L1 homolog, was engaged in theprocess of progesterone-induced oocyte maturation possibly through an involvement in protein turnover anddegradation. | ZHAO GUI SUN1,2,3,*, WEI HUA KONG2,*, YAN JUN ZHANG2, SHAN YAN1, JI NING LU1, ZHENG GU1, FENG LIN1, JIA KE TSO1,**1 National Laboratory of Contraceptives and Devices Research, Shanghai Institute of Planned ParenthoodResearch, Shanghai 200032, China2 Colle | 2002 | Cell Research2002，12，4： | 8 |
| 4 | Alterations in DNA methylation and genome structure in two rice mutant lines induced by high pressure显示文摘By using high-pressure treatment, two mutant lines were obtained from a genetically stable japonica rice cultivar Bijing38. Genomic DNA of the mutant lines, together with the original line (Bijing38), was either undigested or digested by Hpa II/Msp I, and then subjected to molecular analy-sis using two markers, ISSR and RAPD. Results indicated that changes in the PCR amplification pro-files of both markers are apparent in the two mutant lines compared with the original rice cultivar, suggesting that there had been both sequence changes and DNA methylation modifications in the mutant lines. Southern blot analysis using diverse sequences, including two cellular genes (S2 and S3), a set of retrotransposons (Osr7, Osr36, Tos19 and more), and a MITE transposon family (mPing and Pong), confirmed the results, and indicated that changes in DNA methylation pattern, genomic structure, and possible activation of some transposons indeed occurred in the mutant lines. Moreover, these changes are stably maintained through selfed generations and in different organs. Thus, our results indicate that it is possible to obtain stable mutants in rice by high pressure treatments, and the molecular basis of the mutants may include both genetic and epigenetic changes. Therefore, high hydrostatic pressure seems a promising approach for plant mutagenesis. | SHEN Sile1,3, WANG Zhenwei3, SHAN Xiaohui2, WANG Hua3, LI Ling3, LIN Xuyun2, LONG Likun2, WENG Kenan4, LIU Bao2 & ZOU Guangtian1 1. National Laboratory of Superhard Materials, Jilin University, Changchun 130012, China 2. Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China 3. College of Life Science, Jilin University, Changchun 130012, China 4. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China | 2006 | Science China(Life Sciences)2006，49，2： | 6 |
| 5 | Alteration of tumor suppressor gene p16 and Rb in gastric cancinogesis显示文摘Alterationoftumorsuppressorgenep16andRbingastriccancinogesisZHOUQi1,ZOUJianXiang2,CHENYuLong2,YUHuiZhen3,WANGLiDong1,LIYo... | ZHOU Qi1, ZOU JianXiang2, CHEN YuLong2, YU HuiZhen3,WANG LiDong1, LI YongXin1, GUO HuaQin1, GAO ShanShan1, and QIU SongLian11Laboratory for Cancer Research, Medical Experimental Center, 2Department of Gas | 1997 | World Journal of Gastroenterology1997，3，4： | 4 |
| 6 | Flatness and Profile Integration Control Model for Tandem Cold Mills显示文摘Using the effective matrix methods of flatness and profile control synthetically, the flatness and profile integration control scheme for tandem cold mills is built in order to increase flatness and profile control precision of tandem cold mills. Corresponding control strategies are adopted for various control objectives of different stands and the coordination control strategies of various stands are given, which makes the on-line flatness control cooperate with on-line profile control and implements the parallel control of different stands. According to the measured flatness and profile data of some 1550 mm tandem cold mills, the control scheme is verified and the result indicates that the scheme has high flatness and profile control precision with steady and reliable control process. A new way and method is supplied for researching shape control of tandem cold mills. | SHAN Xiu-ying1,2,3, LIU Hong-min1,2, JIA Chun-yu1,2, SUN Jian-liang1,2 (1. Engineering Research Center of Rolling Equipment and Complete Technology of Ministry of Education, Yanshan University, Qinhuangdao 066004, Hebei, China 2. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, Hebei, China 3. Hot Tandem Rolling Factory, Jinan Iron and Steel Co Ltd, Jinan 250101, Shandong, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，3： | 3 |
| 7 | Characterization of Poly(N-Isopropylacrylamide) by Asymmetrical Flow Field- Flow Fractionation, Dynamic Light Scattering, and Size Exclusion Chromatography 显示文摘 | Yohannes G Shan 3 Jussila M | 2005 | JSep Sci2005，28，5： | 1 |
| 8 | Characteristics of Salt Affected Soil and Its Amelioration by Trees显示文摘Salt-affected soils extensively distribute on the earth.Although the causes are various,generally speaking salinization occurrence results from the accumulation of free salts to an extent that causes degradation of vegetation and soils.Besides,irrational human practices have increased soil salinity by allowing excess recharging of groundwater to change the natural balance of the water cycle in the landscape. This reduces the suitability to plant growth and increases the potential for other forms of land ... | ZHANG Jianfeng~1 ZHANG Deshun~(2**) FAN Baomin~3 SHAN Qihua~1 SHEN Liming~4 1.Institute of Subtropical Forestry,Chinese Academy of Forestry,Fuyang 311400,P.R.China 2.College of Architecture and Urban Planning,Tongji University,Shanghai 200092,P.R.China 3.Research Institute of Forestry Information and Policy,Chinese Academy of Forestry,Beijing 100090,P.R.China 4.Forestry Technology Extension Station,Yuyao 315400,P.R.China | 2009 | Chinese Forestry Science and Technology2009，8，1： | 1 |
| 9 | Analysis Algerian's Gallstones with Infrared Spectrum and Methods of Prevention and Treatment for Cholelithiasis in Algeria显示文摘To analyze the type of Algerian’s gallstones and put forward relative measures of prevention and treatment, The NICOLET 170SX FT IR spectrometer was used to measure the infra red spectrum and analyze the feature of spectrum of Algerian’s gallstones. The results shown that Algerian have cholesterol gallstones. Reasons to form Algerian’s multiple cholesterol gallstones were investigated. We have put forward five suggestions to prevent and treat cholelithiasis. | Li Zong shan 1, Dang Zi qin 1, Li Xang qun 1, Zeng Fan qing 2, Gu Ying hong 2, Niu Fei 2, Zhang Hu sheng 3, Hung Xiao Ling 4 1. School of Medicine, Wuhan University, Wuhan 430071, Hubei, China 2. College of Chemistry and Molecular Sciences, Wuha University, Wuhan 430072, Hubei, China 3. School of Physics and Technology, Wuhan University, Wuhan 430072, Hubei, China 4. Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei, China | 2002 | Wuhan University Journal of Natural Sciences2002，7，4： | 0 |
| 10 | Simulation study of real-time monitor for BEPC-Ⅱ luminosity显示文摘A fast and real time luminosity monitor system will be used in the BEPC-Ⅱ(Beijing Electron Positron Collider,China).Photons generated in radiative Bhabha scattering at the interaction point are transformed into charged particles,and then the luminosity of each bunch pair is measured through collecting the Cherenkov light produced by charged particles in fused silica.The whole process happening in the detector is simulated.The physics acceptance and detection threshold with the monitor accu-racy of 1% are set based on the simulation spectra of photoelectron yield calibrated by e-beam data. | SHAN Qing1,2,WU Jian2,XUE Zhen2,XU ZiZong2,HU Tao3,WANG YiFang3 & WANG XiaoLian2 1 College of Material Science and Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China 2 Department of Modern Physics,University of Science and Technology of China,Hefei 230026,China 3 Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China | 2010 | Science China(Technological Sciences)2010，53，5： | 0 |
| 11 | The Study on Produce and Properties ofF-Heparin Surface Modified IOLs显示文摘Objective:To study the biocompatibility of F heparin surface modified IOLs (F HSM IOLs) and provide theoretical and experimental basis for clinical use and new IOL development. Methods The technique of carrier energy ion beam combined with low temperature and low pressure plasma was used to modify the surface of PMMA IOLs. The physicochemical and optical properties of F HSM IOLs were examined. In vitro, the cultured cells adherence and growth on IOLs were studied. In vivo, F HSM IOLs were implanted into rabbits and Rhesus Monkeys eyes. The biocompatibility of F HSM IOLs, PMMA IOLs and HSM IOLs was compared. Results There were fewer adhered cells on the surface of F HSM IOLs with no toxicity to the cultured fibroblasts. F HSM IOLs caused less inflammatory reaction, broke BAB more slightly and decreased posterior capsular opacity. F HSM IOLs possessed better biocompatiblity. Our research also suggested that the brownish F HSM IOLs could prevent the short wave length light and ultraviolet rays from injuring the retina. Conclusion F HSM IOLs possessed better biocompatibility than conventional PMMA IOLs and can be used in clinical works after further inspection and approval. | GU Han qing 1,YUAN Jia qin 2,SUN Hui min 2,ZHANG Hai wen 1,LU Mo gu 1,WANG Gui qin 3,GUO Hong yu 3,XU Yan shan 2This work is funded in part by the National 10th Five Year Plan on Capture Key of Science and Technolog (2001 BA706B17) 1 Tianjin Institute of Urological Surgery,Tianjin 300211,China,2 Tianjin Medical University Eye Center,Tianjin 300070,China 3 Tianjin Medical University,Tiangjin 300070,China | 2003 | Chinese Journal of Biomedical Engineering(English Edition)2003，12，1： | 0 |
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