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| 1 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 2 | Multilinear Singular and Fractional Integrals显示文摘In this paper, we treat a class of non-standard commutators with higher order remaindersin the Lipschitz spaces and give (L^p, L^q), (H^p, L^q) boundedness and the boundedness in the Triebel-Lizorkin spaces. Our results give simplified proofs of the recent works by Chen, and extend his result. | Yong DING Shan Zhen LU Kz YABUTA | 2006 | Acta Mathematica Sinica,English Series2006，22，2： | 8 |
| 3 | Toxicity of arsenate and arsenite on germination, seedling growth and amylolytic activity of wheat 显示文摘 | Liu X L Zhang S Z Shan X Q | 2005 | Chemosphere2005，61，： | 1 |
| 4 | A model for evaluation the phytoavailability of trace elements to vegetables under the field conditions 显示文摘 | WANG X P SHAN X Q ZHANG S Z | 2004 | Chemosphere2004，46，： | 1 |
| 5 | Evaluation of plant availability of soil trace metals by chemical fraetionation and multiple regression analysis显示文摘 | Qian J Wang Z Shan X | 1996 | Environmental Pollution1996，91，： | 1 |
| 6 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 7 | Nutritional status deteriorates as the severity of diabetic foot ulcers increases and independently associates with prognosis 显示文摘 | Shan Z Zheng T Fang P | 2013 | Exp Ther Med2013，5，1： | 1 |
| 8 | Ultrahigh stress and strain in hierarchically structured hollow nanoparticles显示文摘 | SHAN Z ADESSO G CABOT A etal | 2008 | Nature Materials2008，7，18： | 1 |
| 9 | Effect of iodine intake on thyroid disease in China显示文摘 | Teng W Shan Z Teng X | 2006 | N Engl J Med2006，354，： | 1 |
| 10 | Zonal compensation for workpiece elastic deformation through fixture layout optimization显示文摘 | Jiang Z L Liu Y M Shan Y X | 2010 | Applied Mechanics and Materials2010，2628，： | 1 |
| 11 | Pharmacokinetics of doxycyc- line in tilapia ( Oreochromis aureus x Oreochromis niloticus) af- ter intravenous and oral administration显示文摘 | Yang F Li Z L Shan Q | 2014 | J Vet Pharmaeol T- her2014，37，4： | 1 |
| 12 | Transcription factor Ap-1 mediates proangiogenic MIF expression in human endothe- lial cells exposed to Angiotensin II显示文摘 | Shan Z X Lin Q X Yang M | 2011 | Cytokine2011，53，1： | 1 |
| 13 | Low back pain development response to sustained trunk axial twisting显示文摘 | Shan X Ning X Chert Z | 2013 | Eur Spine J2013，22，9： | 1 |
| 14 | Combined toxicity of cadmium and arsenate to wheat seedlings and plant uptake and antioxidative enzyme responses to cadmium and arsenate co-contaminatian 显示文摘 | Liu X L Zhang S Z Shan X Q | 2007 | Ecotoxicology and Environmental Satety2007，68，： | 1 |
| 15 | Tanshinone Ⅱ A protects against sud- den cardiac death induced by lethal arrhythmias via repression of microRNA-1 显示文摘 | Shan H Li X Pan Z et at | 2009 | Br J Pharmaco12009，158，5： | 1 |
| 16 | Effect of iodine intake on thy-roid diseases in China显示文摘 | Teng W Shan Z Teng X | 2006 | N Engl J Med2006，354，26： | 1 |
| 17 | 显示文摘 | Shan Z | 2003 | Applied Catalysis A:General2003，254，： | 1 |
| 18 | Modeling and performance analysis of QoS-aware load balancing of Web server clusters显示文摘 | SHAN Z G LIN C MARINESCU D C | 2002 | Computer Networks Elsevier Science2002，40，2： | 1 |
| 19 | The properties of one-dimensional spin-S(S≥1) antiferromagnetic Ising chain with single-ion anisotropy显示文摘 | Chen X Y Jiang Q Shan W Z | 2003 | J Magn Magn Mater2003，262，： | 1 |
| 20 | The function of the SNP in the MP1 and MMP3 promoter in suscep tibility to endometriosis in China 显示文摘 | Shan K YingW J Jan - Hui Z | 2005 | Mol Hum Rep rod2005，11，： | 1 |
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