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15篇 您的检索式：作者名="Shannon L W"

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		题名	作者	年代	出处	被引量
	1	Regulation of milk protein gene expression显示文摘	Jeffrey M R Shannon L W Darryl H	1999	Annu Rev Nutr1999，19，：	1
	2	Sediment transport and deposition in trickle irrigation laterals显示文摘	Shannon W M James L G Bassett D L	1982	Transactions of the ASAE1982，25，1：	1
	3	Detection of five seedborne legume viruses in one sensitive multi- plex polymerase chain reaction test 显示文摘	Bariana H S Shannon A L Chu P W G	1994	Techniques1994，84，10：	1
	4	The assoeation of particulate air metal concentions with heart rate variability显示文摘	JOEL S PAIGE L W	2002	Environ Health Perspect2002，11，9：	1
	5	American academy of pediatrics:committee on environmental health technical report:mercury in the environment:implications for pediatricians显示文摘	Goldman L R Shannon M W	2001	Pediatrics2001，108，1：	1
	6	Detection of five legume viruses in one sensitive multiplex poly-merase chain reaction test 显示文摘	Bariana H S Shannon A L Chu P W G	1994	Phytopathology1994，84，10：	1
	7	Surface crack shape change in bending fatigue using an inexpensive resonant fatiguing appara- tus显示文摘	Pierce W S Shannon J L	1978	J Test Eval1978，6，：	1
	8	The flotation of pentlandite from pyrrhotite with particular reference to the effects of particle size显示文摘	Senior G D Shannon L K Trahar W J	1994	Int J Miner Process1994，42，34：	1
	9	The framework topology of zeolite EU 显示文摘	BRISCOE N A JOHNSON D W SHANNON M D KOKOTAILO G T MCCUSKER L B	1988	Zcolites1988，8，1：	1
	10	Strength of soils under dynamic loads 显示文摘	Casagrande A Shannon W L	1948	Proceedings of the American Society of Civil Engineers1948，74，4：	1
	11	Flotation of pentlandite from pyrrhotite with particular reference to the effects of particle size 显示文摘	Senior G D Shannon L K Trahar W J	1994	Int J Miner Process1994，42，34：	1
	12	Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice显示文摘	Shannon L Gourley Jonathan W	2012	Psychopharmacology2012，219，：	1
	13	Detection of five legume viruses in one sensitive multiplex polymerase chain reaction test 显示文摘	Bariana H S Shannon A L Chu P W G	1995	Phytopathology1995，84，：	1
	14	Hor mone-induced morphogenesis and growth role of mesenchyma epithelial interactions 显示文摘	CUNHA G R CHUNG L W K SHANNON J M	1983	Recent Prog Horm Res1983，39，：	1
	15	Diabetes exacerbates inflammatory bowel disease in mice with dietinduced obesity显示文摘BACKGROUND The increased prevalence of inflammatory bowel disease(IBD)among patients with obesity and type 2 diabetes suggests a causal link between these diseases,potentially involving the effect of hyperglycemia to disrupt intestinal barrier integrity.AIM To investigate whether the deleterious impact of diabetes on the intestinal barrier is associated with increased IBD severity in a murine model of colitis in mice with and without diet-induced obesity.METHODS Mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range hyperglycemia.Six weeks later,dextran sodium sulfate was given to induce colitis.In select experiments,a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis onset.Endpoints included both clinical and histological measures of colitis activity as well as histochemical markers of colonic epithelial barrier integrity.RESULTS In mice given a high-fat diet,but not chow-fed animals,diabetes was associated with significantly increased clinical colitis activity and histopathologic markers of disease severity.Diabetes was also associated with a decrease in key components that regulate colonic epithelial barrier integrity(colonic mucin layer content and epithelial tight junction proteins)in diet-induced obese mice.Each of these effects of diabetes in diet-induced obese mice was ameliorated by restoring normoglycemia.CONCLUSION In obese mice,diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of hyperglycemia.Hyperglycemia-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis severity.These findings suggest that effective diabetes management may decrease the clinical severity of IBD.	Kendra L Francis Kimberly M Alonge Maria Cristina Pacheco Shannon J Hu Cody A Krutzsch Gregory J Morton Michael W Schwartz Jarrad M Scarlett	2023	World Journal of Gastroenterology2023，29，33：	0

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