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1篇 您的检索式:作者名="Shanthi Palanivelu"
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1Ameliorating effect of Semecarpus anacardium Linn.nut milk extract on altered glucose metabolism in high fat diet STZ induced type 2 diabetic rats显示文摘Objective:To explore the protective effect of the drug Semecarpus anacardium(S.anacardium) on altered glucose metabolism in diabetic rats.Methods:Type 2 diabetes mellitus was induced by feeding rats with high fat diet followed by single intraperitoneal injection of streptozotocin (STZ)(35 mg/kg b.w.).Seven days after STZ induction,diabetic rats received nut milk extract of S.anacardium Linn.nut milk extract orally at a dosage of 200 mg/kg daily for 4 weeks.The effect of nut milk extract of S.anacardium on blood glucose,plasma insulin,glucose metabolising enzymes and GSK were studied.Results:Treatment with SA extract showed a significant reduction in blood glucose levels and increase in plasma insulin levels and also increase in HOMA-βand decrease in HOMA -IR.The drug significantly increased the activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase activity and increased the glycogen content in liver of diabetic rats while reducing the activities of gluconeogenic enzymes.The drug also effectively ameliorated the alterations in GSK-3 mRNA expression.Conclusions:Overall,the present study demonstrates the possible mechanism of glucose regulation of S.anacardium suggestive of its therapeutic potential for the management of diabetes mellitus.Haseena Banu Hedayathullah Khan Kaladevi Siddhi Vinayagam Shanthi Palanivelu Sachdanandam Panchanadham 2012Asian Pacific Journal of Tropical Medicine2012,5,12:3
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