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| 1 | The application of large volume airgun sources to the onshore-offshore seismic surveys: implication of the experimental results in northern South China Sea显示文摘Onshore-offshore seismic experiments were carried out for the first time in northern South China Sea using large volume airgun sources at sea and seismic stations on land. The experimental results indicate that seismic signals from the new airgun array of R/V Shiyan 2 can be detected as far as 255 km. The signal effective area reaches nearly 50000 km2, which covers Hong Kong and Pearl River Delta. Compared with the old airgun array, the signal amplitude, propagation distance and effective area of the new airgun array have been increased notably, which demonstrates that the upgrade of the airgun source was successful. Comparisons with previous experimental results in other regions show that the shooting effect of the new airgun array is similar to those best airgun sources in the world. Especially, it is a new breakthrough in using the permanent seismic stations onshore to record long distance airgun signals offshore, which has great significance to the realization of the 'seismic radar' concept and the 3D seismic surveys of crustal structure in coastal areas. | QIU XueLin CHEN Yong ZHU RiXiang XU HuiLong SHI XiaoBin YE ChunMing ZHAO MingHui XIA ShaoHong | 2007 | Chinese Science Bulletin2007，52，4： | 27 |
| 2 | Modeling net primary productivity of the terrestrial ecosystem in China from 1961 to 2005显示文摘网络主要生产率(NPP ) 是代表生态系统的结构和函数的最重要的索引。NPP 能被动态全球植被模型(DGVM ) 模仿,它被设计相对环境变化代表植被动力学。这研究在气候,土壤,和地形学上与数据基于 DGVM 综合生物圈模拟器(朱鹭) 模仿了瓷器生态系统的 NPP。在瓷器陆上的生态系统的 NPP 模拟的朱鹭的适用性首先被验证。有另外的相关研究的比较显示范围和模拟的吝啬的价值通常在观察的限制以内;全面模式和全部的年度 NPP 接近与另外的模型一起进行的模拟。模拟基于遥感离 NPP 评价也靠近。确认证明那朱鹭能在瓷器自然生态系统在 NPP 的大规模模拟被利用。我们然后从 1961 ~ 2005 与气候变化数据模仿了 NPP,当温暖是特别地惹人注目的时。下列是模拟的结果。(1 ) 全部的 NPP 在过去的 45 年里从 3.61 GtC/yr 变化了到 4.24 GtC/yr 并且展出了最小的重要线性增加或减少。(2 ) 在增加的地区性的差别或在 NPP 的减少大,但是展出了一个不足道的全面线性趋势。NPP 在大多数部分衰退了东方并且华中,特别在黄土高原。(3 ) 类似于年度 NPP 的变化法律,季节的 NPP 也显示了不足道的增加或减少;趋势线在一般水平以内。(4 ) 在季节的 NPP 变化的地区性的差别大。NPP 在黄土高原在春天,夏天,和秋天衰退了,但是在西藏的高原的大多数部分增加了。 | YUAN Quanzhi WU Shaohong ZHAO Dongsheng DAI Erfu CHEN Li ZHANG Lei | 2014 | Journal of Geographical Sciences2014，24，1： | 27 |
| 3 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 4 | Primary resistance to crizotinib treatment in a non-small cell lung cancer patient with an EML4-ALK rearrangement:a case report显示文摘Crizotinib,a small molecular tyrosine kinase inhibitor,manifests dramatic responses in patients with non-small cell lung cancer with echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase(EML4-ALK)rearrangements.ALK gene point mutation is the primary mechanism of acquired crizotinib resistance;however,the intrinsic mechanism is not fully understood.Here,we report a patient with a low mutant allele fraction(MAF)of EML4-ALK rearrangement,who experienced primary resistance to crizotinib treatment.The patient was a 66-year-old Chinese man,who had a history of metastatic lung cancer and was treated with first-and third-generation epidermal growth factor receptor tyrosine kinase inhibitors(EGFR TKIs).After 14 months of osimertinib treatment,his disease progressed,and next-generation sequencing was performed from a liquid biopsy of the patient’s blood.An EML4-ALK rearrangement was found and crizotinib was administered.The patient’s lung lesions continued to progress after one month of crizotinib treatment,and pemetrexed-bevacizumab was initiated.After two cycles of chemotherapy,the metastatic cancers shrunk,and the patient maintained stable disease at his last follow-up.EML4-ALK rearrangements can happen in patients with EGFR-positive NSCLC,after acquired resistance to EGFR TKI treatment.The EGFR T790M and C797G mutations occur in cis is a critical mechanism of resistance to osimertinib therapy.The MAF of EML4-ALK rearrangements in cancer cells might be a predictive factor for crizotinib treatment. | Ling Zhang Yunxia Li Shaohong Zhang Chen Gao Keke Nie Youxin Ji | 2018 | Cancer Biology & Medicine2018，15，2： | 5 |
| 5 | Effects of Huatan Tongluo decoction on vascular endothelial growth factor receptor 2 expression in synovial tissues of rats with collagen-induced arthritis显示文摘OBJECTIVE: To determine the therapeutic effect and potential mechanism of Huatan Tongluo decoction on rats with collagen-induced arthritis.METHODS: Forty specific pathogen-free Wistar rats were selected, and 10 were randomly selected as the control(group 1). The remaining rats were injected intradermally with emulsified type Ⅱ bovine collagen at the tail base and back, followed by a booster 7 d post first immunization. After establishing collagen-induced arthritis(CIA), rats were randomly divided into three groups(n = 10). The rats were treated orally for 30 d as follows: group 1, saline; group 2, model(saline); group 3, tripterygium polyglycoside(TP; 7.81 mg/kg, positive control);group 4, Huatan Tongluo decoction(HTTL; 7.5 g/kg). Body weight, ankle swelling and arthritis index were measured over the course of the study. The rats were sacrificed 30 d after treatment. Morphological changes in the synovium were observed by hematoxylin and eosin staining. Pannus formation and synovial thickness in the left ankle were observed by color Doppler ultrasoundVascular endothelial growth factor(VEGF) and VEGFR2 protein levels were measured by immunohistochemistry.VEGF/VEGFR2 mRNA levels were measured by real-time quantitative polymerase chain reaction.RESULTS: Compared with the model group, a significantly lower arthritis index was observed in the positive control group(P < 0.05) and HTTL group(P < 0.01), after treatment. Both positive control and HTTL reduced intra-articular pannus formation and synovial thickening. Furthermore, VEGF mRNA,and VEGFR2 protein and mRNA levels were significantly downregulated(P < 0.05) in the treatment groups.CONCLUSION: Inhibition of the expression of VEGF and VEGFR2 in synovial tissues and the formation of pannus and synovial hyperplasia may be part of the mechanism of HTTL for relieving the symptoms of rheumatoid arthritis in CIA rats. | Chen Jinchun Qiu Mingshan Li Yihan Zhang Qian Zhang Yiyan Lin Shuangjie Zhang Shaohong Qian Lixia Gao Hai Li Liang-cheng | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 4 |
| 6 | AN SEIRS EPIDEMIC MODEL WITH TWO DELAYS AND PULSE VACCINATION显示文摘脉搏种痘是有效、重要的策略根除传染疾病。作者与二延期和脉搏种痘调查一个 SEIRS 流行模型。由使用频闪观测仪的地图决定的分离动态系统,作者获得如果,传染人口灭绝 R Δ<
1,并且传染人口是一致地坚持的如果 R Δ>
1。结果显示脉搏种痘或大脉搏种痘率的一个短时期是一个足够的条件根除疾病。 | Jianjun JIAO Lansun CHEN Shaohong CAI | 2008 | Journal of Systems Science & Complexity2008，21，2： | 4 |
| 7 | Spreading of Human Babesiosis in China:Current Epidemiological Status and Future Challenges显示文摘Human babesiosis is an infection caused by intraerythrocytic protozoa of the genus Babesia and is a worldwide emerging tick-borne disease(1).Babesia is mainly parasitized in erythrocytes of human or other vertebrates and transmitted by the bite of ticks,blood transfusion,or organ transplantation(1).Humans are generally susceptible to Babesia,especially those who are immunocompromised with conditions such as splenectomy or splenic dysfunction,as well as those of old age,with infirmity,or with other severe diseases. | Muxin Chen Qin Liu Jingbo Xue Shaohong Chen Dana Huang Yingfang Yu Yuchun Cai Yan Lu Peng Song Renli Zhang Lin Ai Jiaxu Chen | 2020 | China CDC weekly2020，2，33： | 3 |
| 8 | Small RNAs in regulating temperature stress response in plants显示文摘Due to global climate change, temperature stress has become one of the primary causes of crop losses worldwide. Much progress has been made in unraveling the complex stress response mechanisms in plants, particularly in the identification of temperature stress responsive protein-coding genes. Recently discovered micro RNAs(mi RNAs) and endogenous small-interfering RNAs(si RNAs) have also been demonstrated as simportant players in plant temperature stress response.Using high-throughput sequencing, many small RNAs,especially mi RNAs, have been identified to be triggered by cold or heat. Subsequently, several studies have shown an important functional role for these small RNAs in cold or heat tolerance. These findings greatly broaden our understanding of endogenous small RNAs in plant stress response control. Here, we highlight new findings regarding the roles of mi RNAs and si RNAs in plant temperature stress response and acclimation. We also review the current understanding of the regulatory mechanisms of small RNAs in temperature stress response, and explore the outlook for the use of these small RNAs in molecular breeding for improvement of temperature stress tolerance in plants. | Qing Liu Shijuan Yan Tifeng Yang Shaohong Zhang Yue-Qin Chen Bin Liu | 2017 | Journal of Integrative Plant Biology2017，59，11： | 3 |
| 9 | Effects of a combination of Japanese Raisin Tree Seed and Flower of Lobed Kudzuvine against acute alcohol-induced liver injury in mice显示文摘Objective:The Flower of Lobed Kudzuvine[Pueraria lobata(Willd.)Ohwi;Gehua in Chinese;GH]and Japanese Raisin Tree Seed(Hovenia dulcis Thunnb.;Zhijuzi in Chinese;ZJZ)are herbs that have been used in China for the treatment of alcohol intoxication and liver diseases.We aimed to evaluate the hepatoprotective potential of a combination of these in mice with acute alcohol-induced liver injury,and to elucidate the mechanisms involved.Methods:Male ICR mice were randomly allocated to six groups:a control group,an alcohol-administered group,and groups that were administered alcohol and one of silibinin,the GH,the ZJZ or a GH-ZJZ combination(at a ratio of 2:1).Animals were orally administered 56%alcohol(Er Guo-tou white spirit,0.12 mL/10 g/d)for 10 days and at the end of this period,hepatic biochemical indicators,antioxidant parameters,alcohol metabolic enzymes,and histopathologic changes were evaluated.Moreover,the expression of the signaling molecules KEAP1,NRF2,and AQP9 were measured by qRT-PCR and western blotting.Results:Compared with the model group,GH-ZJZ(2:1)had lower serum ALT(12.15±0.39,P紏.003),AST(104.07±1.03,P紏.001),and ALP(148.09±2.55,P紏.010)activities,and lower TC(1.97±0.05,P紏.001)and TG(1.54±0.07,P?.002)concentrations.GH-ZJZ(2:1)also significantly increased the hepatic activities of SOD and GSH(4.24±0.25 and 1.57±0.06,respectively;both P<.01),reduced the ROS and MDA concentrations(97.50±3.00 and 2.39±0.19,respectively;both P<.01),and upregulated Nrf2 expression(P<.01).GH-ZJZ(2:1)significantly reduced the expression of KEAP1 and AQP9 in the liver,compared with alcohol-administered mice(P<.01).Importantly,the GH-ZJZ combination caused a more marked improvement in acute liver injury than GH or ZJZ alone.Conclusion:We have demonstrated protective effects of GH-ZJZ(2:1)against acute alcohol-induced hepatic injury,and shown that these effects may be associated with improvements in lipid and alcohol metabolism,antioxidant capacity,and lipid peroxidation. | Wan Xu Shaohong Chen Gansheng Zhong Haiyan Liu Linlin Xiu Xue Yu Feng Chen Na Li Yanmin Lv | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，1： | 2 |
| 10 | MicroRNAs recruit eIF4E2 to repress translation of target mRNAs显示文摘MicroRNAs (miRNAs ) 成员导致 RNA 的 silencing 建筑群(RISC ) 镇压目标 mRNAs 的翻译。当目标 mRNAs 的 5 7-methylguanosine 帽子是众所周知的为 miRNA 压抑重要时,内在的机制不是清楚的。这里,我们证明 TNRC6A 与 eIF4E2 交往,能绑在帽子,但是不能与 eIF4G 交往开始翻译的 eIF4E 的一个相当或相同事物,禁止目标 mRNAs 的翻译。eIF4E2 的 Downregulation 减轻了记者表示的 miRNA 压抑。而且, eIF4E2 downregulation 增加了内长的 IMP1, PTEN 和 PDCD4 的蛋白质层次,其表情被内长的 miRNAs 镇压。我们进一步提供证明 miRNA 与目标 mRNA 提高 eIF4E2 协会的证据。我们建议那 miRNAs 成员 eIF4E2 与 eIF4E 竞争镇压 mRNA 翻译。 | Shaohong Chen Guangxia Gao | 2017 | Protein & Cell2017，8，10： | 2 |
| 11 | Distribution of heavy metals during pyrolysis of waste printed circuit boards显示文摘 | Peng Shaohong Chen Lieqiang Cai Mingzhao | 2006 | Journal of Coal Science and Engineering2006，12，1： | 1 |
| 12 | A delayed stage - structured Holling II predator - prey model with mutual interference and impulsive perturbations on predator显示文摘 | Jiao Jianjun Chen Lansun Cai Shaohong | 2009 | Chaos Solitons Fractals2009，40，4： | 1 |
| 13 | Dynamics of a stage-structured predator_prey model with prey impulsively diffusing between two patches显示文摘 | Jianjun Jiao Lansun Chen Shaohong Cai Limin Wang | 2010 | Nonlinear Analysis: Real World Applications2010，11，： | 1 |
| 14 | Vacuum pyrolysis of waste print circuit board显示文摘 | Gan Ge Chen Lieqiang Peng Shaohong | 2005 | Journal of Coal Science and Engineering2005，11，1： | 1 |
| 15 | Attribution analyses of potential evapotranspiration changes in China since the 1960s显示文摘 | Yin Yunhe Wu Shaohong Chen Gang | | 0，，： | 1 |
| 16 | Evaluation of a rapid ELISA technique for detection of circulating antigens of Toxoplasma gondii 显示文摘 | Rui Chen Shaohong Lu Di Lou | 2008 | Microbiol Immunol2008，52，： | 1 |
| 17 | Attribution analyses of potential evapotranspiration changes in China since the 1960s显示文摘 | Yin Yunhe Wu Shaohong Chen Gang | 2010 | Theor Appl Climatol2010，101，： | 1 |
| 18 | Spatial Variations of b-Values in the Coastal Area of Guangdong显示文摘We used earthquake catalogs recorded by Guangdong Seismological Network from 2008 to 2014 to resolve the spatial variations of b-values in the coastal area of Guangdong, particularly in three key research areas(Yangjiang, Heyuan, and offshore Nanao Island) with strong seismicity. Our results revealed that b-values exhibited significant spatial variations, and zones with low b-values could indicate the most likely seismogenic area of large earthquakes. We observed three clear low b-value patches in the offshore Nanao Island. We found a distinct high b-value peak at the depth of 11 km and two minimum peaks at about 14 and 7–8 km in the Yangjiang area. The overall b-values generally decrease with depth in the Heyuan area. The spatial variations of b-values reflect tectonic anomalies; that is, the ‘low-high-low' distribution of b-values in the offshore Nanao Island and the Yangjiang area may indicate the anomaly of the crustal structure with a weak layer. The b-values of reservoir-induced seismicity are obviously lower than that induced by tectonism. This finding indicates that the reservoir area is generally at high stress state under the condition of high pore pressure. We inferred that large earthquakes might be prone to occur at 10–12 km depth in the offshore Nanao Island, at 12–15 km depth in the Yangjiang area, and at the lower part of the seismic activity zone in the Heyuan area. Moreover, the upstream area of the Xinfengjiang reservoir is the most likely area of future large earthquakes in the Heyuan area. | ZHOU Pengxiang XIA Shaohong SUN Jinlong CAO Jinghe XU Huilong ZHAO Fang CHEN Chuanxu | 2018 | Journal of Ocean University of China2018，17，1： | 1 |
| 19 | Analysis of a stage-structured predator-prey system with birth pulse and impulsive harvesting at different moments 显示文摘 | JIAO Jianjun CA! Shaohong CHEN Lansun | 2011 | Nonlinear Analysis : Real World Applications2011，12，4： | 1 |
| 20 | Assessment on the Diagnostic Capacity for Parasitic Diseases of Health Facilities—China,2019显示文摘What is already known about this topic?Morbidity and prevalence of several major parasitic diseases have been declining in China.To reduce the disease burden of parasitic diseases and protect public health security,conducting accurate diagnoses following timely treatment is important.What is added by this report?In the national competition held in 2019. | Qiang Wang Jing Xu Yuwan Hao Tian Tian Zelin Zhu Xueqiang Zhang Liying Wang Shaohong Chen Jiaxu Chen Ning Xiao Shizhu Li | 2021 | China CDC weekly2021，3，35： | 1 |
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