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| 1 | CCR10 and its ligands in regulation of epithelial immunity and diseases显示文摘Epithelial tissues covering the external and internal surface of a body are constantly under physical,chemical or biological assaults.To protect the epithelial tissues and maintain their homeostasis,multiple layers of immune defense mechanisms are required.Besides the epithelial tissue-resident immune cells that provide the first line of defense,circulating immune cells are also recruited into the local tissues in response to challenges.Chemokines and chemokine receptors regulate tissue-specific migration,maintenance and functions of immune cells.Among them,chemokine receptor CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial immunity.CCL27 is expressed predominantly in the skin by keratinocytes while CCL28 is expressed by epithelial cells of various mucosal tissues.CCR10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the thymus.Circulating T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune response.On the other hand,IgA antibody-producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal sites.Increasing evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or-originated cancer cells for their survival,proliferation and evasion from immune surveillance.Herein,we review current knowledge on roles of CCR10/ligands in regulation of epithelial immunity and diseases and speculate on related important questions worth further investigation. | Na Xiong Yaoyao Fu Shaomin Hu Mingcan Xia Jie Yang | 2012 | Protein & Cell2012，3，8： | 5 |
| 2 | Asymmetric Synthesis of the Ring A Substructure of Genkwadane A显示文摘 | Jing Feng Hongli Yin Yi Man Shaomin Fu BO Liu | 2018 | Chinese Journal of Chemistry2018，36，9： | 1 |
| 3 | Cu(II)-catalyzed intermolecular amidation of C-acylimine:A convenient access to gem-diamino acid derivatives显示文摘 | Zhu Shujie Dong Jia Fu Shaomin et ol | 2011 | Org Lett2011，13，18： | 1 |
| 4 | Chiral Pool Guided Syntheses of Polycyclic Natural Products显示文摘Chiral pools have been commonly utilized as inexpensive and versatile building blocks in organic synthesis.In this account,we provide an overview of our recent synthetic efforts toward polycyclic natural products using chiral natural small molecules(chiral pool)as starting materials.Key achievements during our syntheses include intermolecular Diels-Alder/intramolecular hetero-Diels-Alder cascade to enable modification of previously proposed biosynthetic pathway of bolivianine,Diels-Alder-type dimerization through a conjugated furanyl diene intermediate to achieve three types of lindenane[4+2]dimers,Iron-catalyzed reductive aldol reaction to construct core of rumphellclovane E and[3,3]-rearrangement along with vinylo-gous Pummerer rearrangement to make epoxyquinol substructure of JBIR-23/-24.In the final,the outlook is also presented. | Shaomin Fu Bo Liu | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 5 | Alternative Construction of the Core of Lindenane Sesquiterpenoid显示文摘Comprehensive Summary Alternative synthetic routes toward the tricyclic core of lindenane sesquiterpenoid are presented herein.The route A features an asymmetric organocatalysis enabling desymmetric silylation of diol to establish the desired tertiary alcohol,while the route B consists of an acetate ring opening of chiral epoxy moiety.The common intermediate(16)in both routes can give rise to the core of lindenane sesquiterpenoid via an intramolecular cyclopropanation. | Cichang Ling Zhengsong Huang Yuqiao Zhou Shaomin Fu Bo Liu | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
| 6 | Construction of Angularly Fused Tricyclic Compounds via Photo-induced Radical Cascade Cyclization显示文摘Photo-induced electron transfer (PET) of silyl enol ethers has been employed to synthesize several fused ring systems. However, the method has limited applicability due to its narrow substrate scope, low product yields, unsatisfactory stereo- and regioselectivity. Herein, we report a PET-triggered cascade reaction of silyl enolates that leads to the formation of angularly fused tricyclic scaffolds. The reaction exhibits broad substrate scope and excellent stereoselectivity. The regio- and stereoselectivity of this cascade reaction is elucidated via DFT calculation and conformational analysis. | Mengqin Hu Wei Cao Zhen Wang Yan Hao Ganxing Huang Yuqiao Zhou Song Qin Shaomin Fu Bo Liu | 2023 | Chinese Journal of Chemistry2023，41，19： | 0 |
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