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| 1 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 2 | Polyethylene glycol-modified cobalt sulfide nanosheets for high-performance photothermal conversion and photoacoustic/magnetic resonance imaging显示文摘 | Zhenglin Li Zhuo Li Lei Chen Ying Hu Shaoshan Hu Zhaohua Miao Ye Sun Flemming Besenbacher Miao Yu | 2018 | Nano Research2018，11，5： | 2 |
| 3 | Soil organic carbon distribution in relation to land use and its storage in a small watershed of the Loess Plateau, China显示文摘 | Xuan Fang Zhijing Xue Bicheng Li Shaoshan An | 2011 | Catena2011，，1： | 1 |
| 4 | Zircon U-Pb Ages of Tonalite in Faku,Liaoning Province,China,and the Early Paleozoic Magmatic Activity in the North Margin of the North China Craton显示文摘Objective Due to the Meso-Cenozoic Songliao Basin coverage,the Early Paleozoic continental-margin accretionary belt has not been detected in the middle of the north margin of the North China Craton (Liu et al., 2017a, b). | SHI Yiu ZHANG Zhibin YANG Fan LI Dongtao SHI Shaoshan ZHAO Chunqiang YOU Hongxi | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 1 |
| 5 | Temperature-dependent formation and photorepair of DNA damage induced by UV-B radiation in suspension-cultured tobacco cells 显示文摘 | Shaoshan Li Markus Paulsson Lars Olof Bjǎrn | 2002 | Journal of Photochemistry Photobiology B: Biology2002，66，： | 1 |
| 6 | Numerical Simulation of Unidirectional Stratified Flow by Moving Particle Semi Implicit Method显示文摘Numerical simulation of stratified flow of two fluids between two infinite parallel plates using the Moving Particle Semi-implicit(MPS)method is presented.The developing process from entrance to fully development flow is captured.In the simulation,the computational domain is represented by various types of particles.Governing equations are described based on particles and their interactions.Grids are not necessary in any calculation steps of the simulation.The particle number density is implicitly required to be constant to satisfy incompressibility.The weight function is used to describe the interaction between different particles.The particle is considered to constitute the free interface if the particle number density is below a set point.Results for various combinations of density,viscosity,mass flow rates,and distance between the two parallel plates are presented.The proposed procedure is validated using the derived exact solution and the earlier numerical results from the Level-Set method.Furthermore,the evolution of the interface in the developing region is captured and compares well with the derived exact solutions in the developed region. | Shaoshan Rong Haiwang Li Martin Skote Teck Neng Wong Fei Duan | 2014 | Communications in Computational Physics2014，15，3： | 0 |
| 7 | Call for joint international actions to improve scientific understanding and address soil erosion and riverine sediment issues in mountainous regions显示文摘During the International Workshop on Soil Erosion and Riverine Sediment in Mountainous Regions held in November 2022,scientists from many countries shared their state-of-the-art knowledge and brainstormed to improve scientific understanding for coping with climate change and anthropogenic impacts.Information summarized in this discussion includes proposed key scientific questions and suggested joint actions to reduce soil erosion and riverine sediment problems in mountainous regions. | Fan Zhang Baoyuan Liu Liping Zhu Richard Cruse Dongfeng Li Panos Panagos Pasquale Borrelli Yakov Kuzyakov Shaoshan An | 2023 | International Soil and Water Conservation Research2023，11，3： | 0 |
| 8 | An optimal medicinal and edible Chinese herbal formula attenuates particulate matter-induced lung injury through its anti-oxidative,anti-inflammatory and anti-apoptosis activities显示文摘Objective:Identifying novel strategies to prevent particulate matter(PM)-induced lung injury is crucial for the reduction of the morbidity of chronic respiratory diseases.The combined intervention represented by herbal formulae for simultaneously targeting multiple pathological processes can provide a more beneficial effect than the single intervention.The aim of this paper is therefore to design a safe and effective medicinal and edible Chinese herbs(MECHs)formula against PM-induced lung injury.Methods:PM-induced oxidative stress,inflammatory response and apoptosis A549 cell model were used to screen anti-oxidant,anti-inflammatory and anti-apoptotic MECHs,respectively.A network pharmacology method was utilized to rationally design a novel herbal formula.Ultra performance liquid chromatography-mass spectrometer was utilized to assess the quality control of MECHs formula.The excretion of magnetic iron oxide nanospheres of the MECHs formula was estimated in zebrafish.The MECH formula against PM-induced lung injury was investigated with mice experiments.Results:Five selected herbs were rationally designed to form a new MECH formula,including Citri Exocarpium Rubrum(Juhong),Lablab Semen Album(Baibiandou),Atractylodis Macrocephalae Rhizoma(Baizhu),Mori Folium(Sangye)and Polygonati Odorati Rhizoma(Yuzhu).The formula effectively promoted the magnetic iron oxide nanospheres excretion in zebrafish.The mid/high dose formula significantly prevented PM-induced lung damage in mice by enhancing the activity of SOD and GSH-Px,reducing the MDA and ROS level and attenuating the upregulation of pro-inflammatory cytokine(IL-6,IL-8,IL-1βand TNFa),down regulating the protein expression of NF-κB,STAT3 and Caspase-3.Conclusion:Our findings suggest that the effective MECHs formula will become a novel strategy for preventing PM-induced lung injury and provide a paradigm for the development of functional foods using MECHs. | Huan Zhang Jun Kang Wuyan Guo Fujie Wang Mengjiao Guo Shanshan Feng Wuai Zhou Jinnan Li Ayesha T.Tahir Shaoshan Wang Xinjun Du Hui Zhao Weihua Wang Hong Zhu Bo Zhang | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
| 9 | Investigation on the Resources of Paris Polyphylla var.yunnanensis显示文摘In this study,the resource distribution,morphological characteristics,artificial cultivation and market circulation of Paris Polyphylla var.yunnanensis and its polygerm varieties in Yunnan were investigated by referring to the research literature,field investigation and our planting experience.It is found that P.polyphylla var.yunnanensis is widely distributed in Yunnan Province,realizing large-scale artificial cultivation,while the wild resources of polygerm varieties are almost on the verge of extinction and are in urgent need of protection. | Shicai WU Guo LI Qiping WANG Wenli YANG Xuemei CHEN Jian FENG Ganghua LI Shaoshan ZHANG | 2020 | Medicinal Plant2020，11，6： | 0 |
| 10 | Biological Durability of Heat-Treated Rubber Wood显示文摘In this study,the durability of rubber wood(Hevea brasiliensis) which was thermally treated at 170,185,200,and 215℃for 3 h respectively was investigated.The results showed that the durability of heat-treated rubber wood was improved,and the improvement became more obvious with the increase of the treating temperature. When treated at 185℃or lower temperature,the decay resistance of treated wood had no significant improvement.The lowest weight losses were 21.6%and 6.8%after attack by brown rot fungi(Gloeophyllum trabeum) and white rot fungi (Coriolus versicolor) respectively,which were reached by the specimens treated at 215℃.Their resistance to mold fungi was not improved,but the heat-treated wood performed better than untreated wood when both were painted.In field test,the heat-treated specimens exhibited no advantage in termite resistance compared to untreated. | Li Xiaowen Li Min Qin Shaoshan Li Jianing Lin Weifu | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 11 | Differences Between Solitary Cells and Colonial Cells in the Heteromorphic Life Cycle of Phaeocystis globosa: Morphology, Physiology, and Transcriptome显示文摘Large-scale blooms of Phaeocystis globosa have caused serious damage to marine ecosystems in coastal waters of China.Phaeocystis blooms depend on the competitive advantage of their heteromorphic life history:colony formation has the benefit of resisting herbivory by zooplankton,and solitary cells can absorb nutrients rapidly.In order to better understand the mechanisms underlying the metabolic differences between the two types of cells,morphological observations,rapid light curve analysis,fatty acid profiling,and transcriptome assessment were conducted in the laboratory.The rapid light curve of colonial cells was higher than that of solitary cells,which indicated that colonial cells had higher CO2 fixation capacity.The fatty acid level of colonial cells was evidently lower than that of solitary cells,which is consistent with down-regulated synthesis of fatty acids and up-regulated degradation of fatty acids in the transcriptome.ATP-binding cassette transporters,the TCA cycle,and biosynthesis of exopolysaccharides(EPS)also displayed obvious differences.In summary,colonial cells have stronger carbon fixation capacity.They do not synthesize fatty acids as energy storage materials but secrete EPS,which might be one of the mechanisms of colony formation.Here we present a physiological and molecular overview of the differences between solitary cells and colonial cells and thereby provide further insight to help unravel the mechanisms that help Phaeocystis globosa adapt to different environments. | LIANG Dayong WANG Xiaodong HUO Yiping WANG Yan LI Shaoshan | 2021 | Journal of Ocean University of China2021，20，4： | 0 |
| 12 | Developmental Threshold Temperature and Effective Accumulated Temperature of Potosia brevitarsis Lewis显示文摘[Objective]The paper was to study the relationship between temperature and development of Potosia brevitarsis Lewis.[Methods]Six constant temperatures(21,24,27,30,33 and 36℃)were set in the laboratory to study developmental threshold temperature and effective accumulated temperature of P.brevitarsis.[Result]The developmental durations of various states of P.brevitarsis were shortened with the increasing temperature ranged from 21℃to 36℃;the developmental rates were accelerated with the increasing temperature.The developmental threshold temperatures of egg,larva,pupa and pre-oviposition of adult were estimated to be 12.79,9.15,14.86 and 13.80℃,respectively;the effective accumulated temperature were 136.25,3 031.31,308.92 and 98.35 d·℃,respectively.The developmental threshold temperature and effective accumulated temperature for one complete generation were 9.96℃and 3 628.73 d·℃,respectively.Combined with meteorological data,the theoretical generation number of P.brevitarsis occurred in Shihezi was presumed to be one per year,which was basically coincided with actual occurrence generations in fields.[Conclusion]The paper provided theoretical basis for effective control against P.brevitarsis. | Liu Zheng Sun Yan Chen Bing Zhang Xuekun Wang Shaoshan Li Guoying | 2013 | Plant Diseases and Pests2013，4，5： | 0 |
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