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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | Malignant melanoma: Primary surgical management based on pathology and staging显示文摘 | Harris MN Shapiro RL Roses DF | 1995 | Cancer1995，75，2： | 1 |
| 3 | Maternal satisfaction with singledose spinal analgesia for labor pain in Indonesin :a landmark study 显示文摘 | Shapiro RL Thior I Gilbert PB | 2008 | Joumal of Anesthesia2008，，22： | 1 |
| 4 | Hemorrhagic dilatation of the fourth ventricle: an ominous predictor 显示文摘 | Shapiro SA Campbell RL Scully T | 1994 | J Neurosurg1994，80，5： | 1 |
| 5 | Fulminant hepatic failure: summary of a workshop显示文摘 | Hoofnagle JH Carithers Jr RL Shapiro C | 1995 | Hepatology1995，21，1： | 1 |
| 6 | Surgical approaches to malignant melanoma practcal guidelines显示文摘 | Shapiro RL | 2002 | Dermatol Clin2002，20，： | 1 |
| 7 | Role of gulf coast oysters harvested in warmer months in Vibrio vulnificus infections in United States,1988-1996显示文摘 | Shapiro RL Altekruse S Hutwagner L | 1998 | Infect Dis1998，178，： | 1 |
| 8 | Hemorrhagic dilatation of the ventricle:an ominous predictor显示文摘 | Campbell RL Scully T | 1994 | J Neurosurg1994，80，： | 1 |
| 9 | Stimulation of CD8+ T cell responses to MAGE-3 and Melan A/MART-1 by immunization to a polyvalent melanoma vaccine显示文摘 | Reynolds SR Oratz R Shapiro RL | 1997 | Int J Cancer1997，72，6： | 1 |
| 10 | Fulminant hepatic failure: summary of workshop显示文摘 | Hoofnagle JH Carithers RL Jr Shapiro C | 1995 | Hepatology1995，21，1： | 1 |
| 11 | Hemorrhagic dilation of the fourth ventricle: an ominous predictor 显示文摘 | Shapiro SA Campbell RL ScuUy T | 1994 | J Neurosurg1994，80，5： | 1 |
| 12 | Hemorrhage diletion of the fourth ventricle:an ominous predict显示文摘 | Shapiro SA Campbell RL Scull T | 2004 | J Neurosurg2004，80，： | 1 |
| 13 | Paclitaxel- induced apoptosis and mitotic arrest assessed by serial fine- needle aspiration: implications for early prediction of breast cancer response to neoadjuvant treatment 显示文摘 | Symmans WF Volm MD Shapiro RL | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 14 | The role of gulf coast oysters harvested in warmer months in Vibrio vulnificus infections in the United States,1988-1996 Vibrio working group显示文摘 | Shapiro RL Altekruse S Hutwagner L | | 0，，： | 1 |
| 15 | Hemorrhagic dilation of the fourth ventricle:an ominous predictor显示文摘 | Shapiro AS Campbell RL Scully T | | 0，，05： | 1 |
| 16 | Hemorrhagic dilation of the fourth ventricle:an ominous predictor显示文摘 | Shapiro SA Camplell RL Seully T | 1994 | J Neurosurg1994，80，5： | 1 |
| 17 | Hemorrhagic dilation of the fourth ventricle:an ominous predictor显示文摘 | Shapiro SA Camplell RL Seully T | 1994 | J Neurosurg1994，80，： | 1 |
| 18 | HIV transmission and 24-month sur- vival in a randomized trial of HAART to prevent MTCT during pregnancy and breasffeeding in Botswana显示文摘 | Shapiro RL Kitch D Ogwu A | 2013 | AIDS2013，27，12： | 1 |
| 19 | Hemorrhagic dilatation of the ventricle : an ominous predictor 显示文摘 | Shapiro SA Campbell RL Scully T | 1994 | Neurosurgery1994，80，： | 1 |
| 20 | Development of tumor- infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy显示文摘 | Demaria S Volm MD Shapiro RL | 2001 | Clin Cancer Res2001，7，10： | 1 |
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