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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | 人体心脏运动对多普勒血流速度频谱测定的影响显示文摘目的 观察多普勒血流速度频谱上的心脏运动性多普勒频移信号的幅度是否能真正代表心脏局部运动的速度 ,进而为纠正血流速度频谱中血流速度测量误差提供方法。方法 以心尖部为探测点 ,主动脉瓣环处M型超声心动图不同相位的最大运动速度为标准 ,观察主动脉瓣口多普勒血流速度频谱中相应相位的心脏运动性多普勒频移信号的峰值速度是否与M型测得者相关。结果 心脏运动性多普勒频谱信号不同相位的峰值运动速度与M型超声心动图所测得的相应相位的最大运动速度相关非常显著 ,r=0 .99。结论 根据本研究和体外模拟实验研究 ,血液通过各瓣口的真实峰值血流速度为血流速度频谱显示的最大血流速度与心脏运动性多普勒频移信号的峰值速度之和。 | 曹铁生 袁丽君 阮骊韬 段云友 Shapiro SM Ginzton LE | 2001 | 中华超声影像学杂志2001，10，12： | 2 |
| 3 | Role of glutamate receptor-mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model显示文摘 | McDonald JW Shapiro SM Silverstein FS | 1998 | Exp Neurol1998，150，： | 1 |
| 4 | The jaundiced gunn rat model of auditory neuropathy / dyssynchrony显示文摘 | Shaia WT Shapiro SM Spencer RF | 2005 | Laryngoscope2005，115，： | 1 |
| 5 | New concepts in bilirubin encephalopathy显示文摘 | Ostrow JD Pascolo L Shapiro SM | 2003 | Eur J Clin Invest2003，33，11： | 1 |
| 6 | New concepts in bilirubin encephalopathy显示文摘 | Ostrow JD Pascolo L Shapiro SM | 2003 | Eur J Clin Invest2003，33，11： | 1 |
| 7 | Primary pulmonary hypertension: improved long-term effects and survival with continuous intravenous epoprostenol infusion 显示文摘 | Shapiro SM Oudiz R J Cao T | 1997 | J Am Coll Cardiol1997，30，2： | 1 |
| 8 | Transesophageal and Doppler echocardiography in the diagnosis and management of infective endocarditis 显示文摘 | Shapiro SM Bayer AS | 1991 | Chest1991，100，4： | 1 |
| 9 | Regwlation of fasted blood glucose by resitin显示文摘 | Banerjee RR Rangwala SM Shapiro JS | 2004 | Science2004，303，： | 1 |
| 10 | Hyperbilirubinemia and kemicterus显示文摘 | Shapiro SM Bhutani YK Johnson L | 2006 | Clin Perinatol2006，33，2： | 1 |
| 11 | Regulation of fasted blood glucose by resistin 显示文摘 | Banerjee RR Rangwala SM Shapiro JS | 2004 | Science2004，303，5661： | 1 |
| 12 | Bilirubin toxicity in the developing nervous system显示文摘 | Shapiro SM | 2003 | Pediatr Neurol2003，29，： | 1 |
| 13 | Regulation of fasted blood glucose by resistin 显示文摘 | Banerjee RR Rangwala SM Shapiro JS | 2004 | Science2004，303，20： | 1 |
| 14 | Bilirubin and the auditory system 显示文摘 | Shapiro SM Nakamura H | 2001 | Journal of Perinatology2001，21，： | 1 |
| 15 | Bilirubin toxicity in the developing nervous system 显示文摘 | Shapiro SM | 2003 | Pediatr Neurol2003，29，5： | 1 |
| 16 | The jaundiced Gunn rat model of auditory neuropathy/dyssynchrony 显示文摘 | Shaia WT Shapiro SM Spencer RF | 2005 | Laryngo scope2005，115，： | 1 |
| 17 | Definition of the clinical spectrum of kemicterus and bilirubin -induced neurological dysfunction (BIND) 显示文摘 | Shapiro SM | 2005 | Perinato 12005，25，： | 1 |
| 18 | New concepts in bilirubin encephalopathy显示文摘 | Ostrow JD Pascolo L Shapiro SM | 2003 | Eur J Clin Invest2003，33，11： | 1 |
| 19 | The jaundiced gunn rat model of auditory neuropathy / dyssynchrony显示文摘 | Shaia WT Shapiro SM Spencer RF | 2005 | Laryngoscope2005，115，： | 1 |
| 20 | Long-lasting reduction of inhibitory function and y-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy 显示文摘 | Rice A Rafiq A Shapiro SM | 1996 | Proc Natl AcadSci USA1996，93，： | 1 |
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