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| 1 | Response of blood pressure after percutaneous transluminal renal artery angioplasty and stenting显示文摘AIM: To evaluate the short and intermediate term out-come of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. METHODS: We conducted a prospective analysis of all patients who underwent PTRA and stenting in our institute between August 2010 to September 2012. A total number of 86 patients were underwent PTRA and renal stenting. Selective angiography was done to confirm at least 70% angiographic stenosis. The predilatation done except few cases with critical stenosis, direct stenting was done in the rest of cases. All patients received aspirin 325 mg orally, and clopidogrel 300 mg orally within 24 h before the procedure. Heparin was used as the procedural anticoagulant agent. Optimal results with TIMI-Ⅲ flow obtained in all cases. Following stent placement, aspirin 150 mg orally once daily was continued for a minimum of 12 mo and clopidogrel 75 mg orally once daily for at least 4 wk. The clinical, radiological, electrocardiography, echocardiography and treatment data of all patients were recorded. The BP measurement, serum creatinine and glomerular filtration rate (GFR) were recorded before the procedure and 1 and 6 mo after PTRA. RESULTS: A total of 86 patients were included in the study. The mean age of study population was 55.87±11.85 years old and 67 (77.9%) of patients were male. There was a significant reduction in both systolic and diastolic BP at 1 mo after the procedure: 170.15±20.10 mmHg vs 146.60±17.32 mmHg and 98.38±10.55 mmHg vs 89.88±9.22 mmHg respectively (P=0.0000). The reduction in BP was constant throughout the follow-up period and was evident 6 mo after the procedure: 144.23±18.19 and 88.26±9.79 mmHg respectively (P=0.0000). However, no improvement in renal function was observed at any time during the follow-up period. After multivariate analysis, we found male sex, low GFR (<60 mL/min) and higher baseline mean BP as a poor predictors of successful outcome on BP response after PTRA and stenting. CONCLUSION: The PTRA and stenting can be considered as an effective therapeutic intervention for improving BP control with minimal effect on renal function. The male sex, higher baseline BP and low GFR are associated with poor BP response after successful PTRA and stenting. | Jayesh S Prajapati Sharad R Jain Hasit Joshi Shaurin Shah Kamal Sharma Sibasis Sahoo Kapil Virparia Ashok Thakkar | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 2 | Examining Transport Futures with Scenario Analysis and MCA显示文摘 | Robin H Sharad S | | 0，，： | 1 |
| 3 | Liquisolid corn- pact: a new technique for enhaneement of drug dissolution 显示文摘 | Sahil M G Sharad S P Shirish V S | 2011 | Int JRes Pharm Chem2011，1，3： | 1 |
| 4 | Synthesis and Characterization o{ Polyamides Con- taining Pendant Pentadecyl Chains显示文摘 | Arvind S More Sharad K Pasale Prakash P Wadga- onkar | 2010 | European Polymer Journal2010，46，： | 1 |
| 5 | Textural properties of ambient pressure dried water-glass based silica aerogel beads: One day synthesis显示文摘 | Sharad D B Kim Y H Ahn Y S | 2006 | Microporous and Mesoporous Materials2006，96，123： | 1 |
| 6 | Rapid synthesis of water-glass based aerogels by in situ surface modification of the hydrogels显示文摘 | Sharad D B Kim Y H Ahn Y S | 2007 | Applied Surface Science2007，253，6： | 1 |
| 7 | Destruction of phenol from wastewater by oxidation with sulfite-oxygen显示文摘 | Kulkarni Umesh S Dixit Sharad G | 1991 | Industrial&Engineering Chemistry Research1991，30，8： | 1 |
| 8 | Skin regenerativepotentials of cureumin 显示文摘 | Thangapazham RL Sharad S Maheshwari RK | 2013 | Biofactors2013，39，1： | 1 |
| 9 | Neglected lateral process of talus fracture presenting as a loose body in tarsal canal显示文摘如果误诊,距骨的侧面的过程破裂是有一个潜力的稀罕损害引起重要病态。这些破裂的适当管理仍然是争论的,仅仅一些报告在这个题目上是可得到的。我们在在损害的时候被误诊的距骨的侧面的过程上与忽视的骨折介绍了 37 岁的男性的一个案例。长期的脚关节疼痛地在错误诊断以后介绍给 7 个月的病人。我们的案例在它是在湾穴 tarsi 作为松开的身体介绍了的距骨的侧面的过程上的忽视的骨折的一个稀罕案例的意义是唯一的。然而,有松开的身体的切除的一个手术与 2 years’ 一起介绍了令人满意的结果后续。到我们的知识,它应该是在英语文学报导的第一个案例。通过这份案例报告,当评估损伤到脚关节的侧面的方面时,我们为如此的稀罕多骨的损害强调怀疑的高索引的重要性并且讨论这些破裂的管理的原则。 | Kamal Bail Sharad Prabhakar Nitesh Gahlot Mandeep S Dhillon | 2011 | Chinese Journal of Traumatology2011，14，6： | 1 |
| 10 | Constructing table-of- content for videos 显示文摘 | Rui Yong Huang Thomas S Mehrotra Sharad | 1999 | Multimedia Systems1999，7，5： | 1 |
| 11 | Content-Based Image Retrieval with Relevance Feedback in MARS显示文摘 | Thomas S Huang Sharad Mehrotra | 1997 | ICIP1997，，2： | 1 |
| 12 | Content-Based Image Retrieval with Relevance Feedback in MARS 显示文摘 | Yong Rui Thomas S Huang Sharad Mehrotra | 1997 | ICIP1997，，2： | 1 |
| 13 | Conceptual design of a high temperature supercon- ducting generator 显示文摘 | Sharad K Singh David W Scherbarth Ernest S Ortoli | 1999 | IEEE Transactions on Applied Superconductivity1999，9，2： | 1 |
| 14 | Disparity between neurophysiologic measurements and clinical reality following peripheral nerve transaction and microneuroaphy显示文摘 | Goldberg MD Sharad S Deshpande | 1984 | Surg Forum1984，35，： | 1 |
| 15 | Correlation of circulatory immunoglobulin levels with Mu opiate receptor allele 显示文摘 | Sharad S Gupta AK Singh RA | 2007 | Indian J Biochem Biophys2007，44，5： | 1 |
| 16 | Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly显示文摘Cytoskeletal networks play an important role in regulating nuclear morphology and ciliogenesis.However,the role of microtubule(MT)post-translational modifications in nuclear shape regulation and cilium disassembly has not been explored.Here we identified a novel regulator of the tubulin polyglutamylase complex(TPGC),C11ORF49/CSTPP1,that regulates cytoskeletal organization,nuclear shape,and cilium disassembly.Mechanistically,loss of C11ORF49/CSTPP1 impacts the assembly and stability of the TPGC,which modulates long-chain polyglutamylation levels on microtubules(MTs)and thereby balances the binding of MT-associated proteins and actin nucleators.As a result,loss of TPGC leads to aberrant,enhanced assembly of MTs that penetrate the nucleus,which in turn leads to defects in nuclear shape,and disorganization of cytoplasmic actin that disrupts the YAP/TAZ pathway and cilium disassembly.Further,we showed that C11ORF49/CSTPP1-TPGC plays mechanistically distinct roles in the regulation of nuclear shape and cilium disassembly.Remarkably,disruption of C11ORF49/CSTPP1-TPGC also leads to developmental defects in vivo.Our findings point to an unanticipated nexus that links tubulin polyglutamylation with nuclear shape and ciliogenesis. | Lei Wang Sharad C.Paudyal Yuchen Kang Mikito Owa Feng-Xia Liang Alexander Spektor Holger Knaut Irma Sánchez Brian D.Dynlacht | 2022 | Cell Research2022，32，2： | 1 |
| 17 | Lysoeomal degradability of poly(a- amino acids)显示文摘 | Chiu Hsinchong Pavla KoFekova Sharad S D | 1997 | J Biomed Mater Res1997，34，3： | 1 |
| 18 | Phospholipid diversi- ty: correlation with membrane-membrane fusion events 显示文摘 | Deeba F Tahseen H N Sharad K S | 2005 | BBA-Biomemhranes2005，1669，2： | 1 |
| 19 | Constructing Table- of- Content for Videos显示文摘 | Yong Rui Thomas S Huang Sharad Mehrotra | 1999 | Multimedia Systems1999，，7： | 1 |
| 20 | A118G polymorphism in mu opioid receptor gene (OPRM1):association with opiate addiction in subjects of Indian origin显示文摘 | Kapur S Sharad S Singh RA | 2007 | J Integr Neurosci2007，6，4： | 1 |
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