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您的检索式：作者名="Sharfman Mark"
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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Changing Institutional Roles:The Evolution of Philanthropy, 1883-1953 显示文摘 | Sharfman Mark | 1994 | Business and Society1994，33，3： | 1 |
| 3 | Does decision process matter? a study of strategic decision-making effectiveness显示文摘 | Dean James W Jr Mark P Sharfman | 1996 | Academy of Management Journal1996，39，2： | 1 |
| 4 | Antecedents of organizational slack 显示文摘 | } SHARFMAN MARK P | 1988 | A- cademy of Management Review1988，，13： | 1 |
| 5 | Visibility and the Antecedents of Corporate Social Performance: An Investigation of the Instrumental Perspective 显示文摘 | Shih - Chi Chiu and Mark Sharfman Legitimacy | 2011 | Journal o Management2011，37，6： | 1 |
| 6 | Legitimacy, visi- bility, and the antecedents of corporate social performance: an investigation of the instrumental perspective显示文摘 | SHIH-CHI CHIU MARK SHARFMAN | 2011 | Journal of Management2011，37，6： | 1 |
| 7 | The construct validity of the Kinder, Lydenberg & Domini social performance ratings data显示文摘 | Mark Sharfman | 1996 | Journal of Business Ethics1996，，3： | 1 |
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