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| 1 | Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage显示文摘Objective Intracerebral hemorrhage(ICH)refers to predominant,sporadic,and non-traumatic bleeding in the brain parenchyma.The PI3K/AKT/mTOR signaling pathway is an important signal transduction pathway regulated by enzyme-linked receptors and has many biological functions in mammals.It plays a key role in neuronal metabolism,gene expression regulation,and tissue homeostasis in the healthy and diseased brain.Methods In the present study,the role of the PI3K/AKT/mTOR pathway inhibitor chrysophanol(CPH)(10 mg/kg and 20 mg/kg,orally)in the improvement of ICH-associated neurological defects in rats was investigated.Autologous blood(20µL/5 min/unilateral/intracerebroventricular)mimics ICH-like defects involving cellular and molecular dysfunction and neurotransmitter imbalance.The current study also included various behavioral assessments to examine cognition,memory,and motor and neuromuscular coordination.The protein expression levels of PI3K,AKT,and mTOR as well as myelin basic protein and apoptotic markers,such as Bax,Bcl-2,and caspase-3,were examined using ELISA kits.Furthermore,the levels of various neuroinflammatory cytokines and oxidative stress markers were assessed.Additionally,the neurological severity score,brain water content,gross brain pathology,and hematoma size were used to indicate neurological function and brain edema.Results CPH was found to be neuroprotective by restoring neurobehavioral alterations and significantly reducing the elevated PI3K,AKT,and mTOR protein levels,and modulating the apoptotic markers such as Bax,Bcl-2,and caspase-3 in rat brain homogenate.CPH substantially reduced the inflammatory cytokines like interleukin(IL)-1β,IL-6,and tumor necrosis factor-α.CPH administration restored the neurotransmitters GABA,glutamate,acetylcholine,dopamine,and various oxidative stress markers.Conclusion Our results show that CPH may be a promising therapeutic approach for overcoming neuronal damage caused by the overexpression of the PI3K/AKT/mTOR signaling pathway in ICH-induced neurological dysfunctions in rats. | Kuldeep Singh JADAUN Sidharth MEHAN Aarti SHARMA Ehraz Mehmood SIDDIQUI Sumit KUMAR NaifALSUHAYMI | 2022 | Current Medical Science2022，42，2： | 5 |
| 2 | Crystallization Behavior of Li2O-ZnO-SiO2 Glass-ceramics System 显示文摘 | Madhumita C Qswami Sengupta P Kuldeep Sharma | 2007 | Ceramics International2007，33，： | 1 |
| 3 | Ex- ploring potential of micro-Raman spectroscopy for corre- lating graphitic distortion in carbon fibers with stresses in erosive wear studies of PEEK composites 显示文摘 | Mohit Sharma Jayashree Bijwe Kuldeep Singh | 2011 | Wear2011，270，11： | 1 |
| 4 | Crystallization behavior of Li2O-ZnO-SiO2 glass-ceramics system显示文摘 | Madhumita Goswami Sengupta P Kuldeep Sharma | 2007 | Ceramics International2007，33，： | 1 |
| 5 | Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum显示文摘 | Subash Chandra Mohapatra Hemandra Kumar Tiwari Manisha Singla Brijesh Rathi Arun Sharma Kuldeep Mahiya Mukesh Kumar Saket Sinha Shyam Singh Chauhan | 2010 | JBIC Journal of Biological Inorganic Chemistry2010，，3： | 1 |
| 6 | A study of finite size effects on cracked 2-D piezoelectric media using extended finite element method 显示文摘 | Bhargava R R Sharma Kuldeep | 2011 | Computational Materials Science2011，50，6： | 1 |
| 7 | X-FEM simulation for two-unequal-collinear cracks in 2-D finite piezoelectric specimen 显示文摘 | Bhargava R R Sharma Kuldeep | 2012 | International Journal of Mechanics and Materials Design2012，8，2： | 1 |
| 8 | Okhunov Z, Friedlander IJ, George AK, Duty BD, Moreira DM, Srinivasan AK, Hillelsohn J, Smith AD, and Okeke Z. S.T.O.N.E. Nephrolithometry: novel surgical Classification system for kidney calculi. Urology. 2013doi: 10.1016/j.urology. 2012.10.083显示文摘 | Kuldeep Sharma Apul Goel Saurabh Gupta | 2013 | Urology2013，，： | 1 |
| 9 | Autonephrectomy due to urogenital tuberculosis显示文摘A 45-year-old male presented with history of left flank pain for 1 year,which was mild dull aching in nature.Plain X-ray film of the urinary tract(Fig.1)was suggestive of diffuse calcification in the left renal area(broad arrow)along with calcification in the ipsilateral ureter region(thin arrows).Chest X-ray was normal. | Rahul J.Sinha Ankur Jhanwar Vishwajeet Singh Kuldeep Sharma Gaurav Prakash C.N.Mehrotra | 2017 | Asian Journal of Urology2017，4，2： | 1 |
| 10 | LC‐MS/MS‐ESI method for simultaneous quantitation of metformin and repaglinidie in rat plasma and its application to pharmacokinetic study in rats显示文摘 | Kuldeep Sharma Gopal Pawar Swetha Yadam Sanjeev Giri Sriram Rajagopal Ramesh Mullangi | 2012 | Chromatogr2012，，3： | 1 |
| 11 | Altered gut microbiota patterns in COVID-19:Markers for inflammation and disease severity显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection leads to a severe respiratory illness and alters the gut microbiota,which dynamically interacts with the human immune system.Microbiota alterations include decreased levels of beneficial bacteria and augmentation of opportunistic pathogens.Here,we describe critical factors affecting the microbiota in coronavirus disease 2019(COVID-19)patients.These include,such as gut microbiota imbalance and gastrointestinal symptoms,the pattern of altered gut microbiota composition in COVID-19 patients,and crosstalk between the microbiome and the gut-lung axis/gut-brain-lung axis.Moreover,we have illustrated the hypoxia state in COVID-19 associated gut microbiota alteration.The role of ACE2 in the digestive system,and control of its expression using the gut microbiota is discussed,highlighting the interactions between the lungs,the gut,and the brain during COVID-19 infection.Similarly,we address the gut microbiota in elderly or co-morbid patients as well as gut microbiota dysbiosis of in severe COVID-19.Several clinical trials to understand the role of probiotics in COVID-19 patients are listed in this review.Augmented inflammation is one of the major driving forces for COVID-19 symptoms and gut microbiome disruption and is associated with disease severity.However,understanding the role of the gut microbiota in immune modulation during SARS-CoV-2 infection may help improve therapeutic strategies for COVID-19 treatment. | Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya Kuldeep Dhama Sang-Soo Lee | 2022 | World Journal of Gastroenterology2022，28，25： | 0 |
| 12 | Assessment of reproductive health service utilization in urban slums: Evidence from Western Rajasthan显示文摘Objective:To assess the utilization of reproductive health services in urban slum of Jodhpur city,India.Methods:A community based cross-sectional study was conducted in an urban slums of Jodhpur city amongst 300 married women of reproductive age between March and June 2021.Semi-structured questionnaire was used to gather demographic data and information about utilization of antenatal care(ANC)services,delivery and post-partum services.Results:The majority of females were aged less than 25 years(n=195;65.0%),married after 18 years(n=240;80%),living in extended families(n=265;88.3%)and with monthly family income less than 10000 rupees(n=182;60.7%).Statistically significant associations were found between≥4 ANC visits and educational level of secondary and above(OR 2.47,95%CI 1.03–6.28;P=0.04),older age(OR 15.70,95%CI 14.87–16.54 for women aged 26-35 years,OR 16.14,95%CI 12.12–20.01 for women aged≥36 years;P<0.01),and backward and general castes(OR 15.91,95%CI 13.57–17.85 for backward caste and OR 8.11,95%CI 8.07–8.26 for general category of caste;P<0.01).Seven percent of females had undergone parturition.Older age was associated with higher risks of postpartum complications(OR 1.06,95%CI 1.01–1.57 for women aged 26-35 years,OR 3.56,95%CI 1.29–4.69 for women aged≥36 years;P<0.01).In addition,risks of postpartum complications were associated with backward and general castes(OR 1.69,95%CI 1.34–2.13 for backward classes and OR 5.01,95%CI 4.29–5.31 for general category castes;P<0.01),and more than 4 ANC visits(OR 0.20,95%CI 0.09–0.34;P<0.01).Conclusions:More frequent ANC visits are associated with a lower risk of postpartum complications.Furthermore,a high utilization of reproductive health services represents good implementation of reproductive and child health programme at the peripheral level resulting in a stark rise in maternal health indicators in the state of Rajasthan. | Jyoti Sharma Nitin Kumar Joshi Yogesh Kumar Jain Kuldeep Singh Pankaj Bhardwaj | 2023 | Asian pacific Journal of Reproduction2023，12，2： | 0 |
| 13 | Some recent studies on glass/glass-ceramics for use as sealants with special emphasis for high temperature applications显示文摘Glass-ceramics owing to a combination of useful properties such as tuneable thermal expansion coefficient(TEC),good mechanical durability and chemical inertness find widespread uses in a variety of applications including seals and coatings.Glass-ceramic-to-metal seals have been fabricated with various silicate,phosphate and borate based oxide glasses depending upon the intended application.In this article,we review our studies on various glass and glass-ceramics materials development with a view to understand bonding behaviour with metals/alloys at ambient and high temperatures through a comprehensive structure property correlation investigations.Detail studies on BaO-CaO-Al2O3-B2O3-SiO2(BCABS),barium strontium alumino-silicate,and strontium alumino-silicate with different additives(like Nd2O3,La2O3,NiO,TiO2,V2O5,ZrO2,Cr2O3,and P2O5)and barium/strontiun zinc silicate(B/SZS)glass-ceramics for high temperature sealing.We shall illustrate the role of various thermo-physical and structural characterization techniques that allowed optimum selection of materials and processing parameters.We particularly highlight the complementary role of NMR and XRD in studying the material at the short range and long range length scales. | G.P.Kothiyal Madhumita Goswami Babita Tiwari Kuldeep Sharma A.Ananthanarayanan Lionel Montagne | 2012 | Journal of Advanced Ceramics2012，1，2： | 0 |
| 14 | Technologies Behind the Smart Grid and Internet of Things: A System Survey显示文摘Electric smart grids enable a bidirectional flow of electricity and information among power system assets.For proper monitoring and con-trolling of power quality,reliability,scalability and flexibility,there is a need for an environmentally friendly system that is transparent,sustainable,cost-saving,energy-efficient,agile and secure.This paper provides an overview of the emerging technologies behind smart grids and the internet of things.The dependent variables are identified by analyzing the electricity consumption patterns for optimal utilization and planning preventive maintenance of their legacy assets like power distribution transformers with real-time parameters to ensure an uninterrupted and reliable power supply.In addition,the paper sorts out challenges in the traditional or legacy electricity grid,power generation,transmission,distribution,and revenue management challenges such as reduc-ing aggregate technical and commercial loss by reforming the existing manual or semi-automatic techniques to fully smart or automatic systems.This article represents a concise review of research works in creating components of the smart grid like smart metering infrastructure for postpaid as well as in prepaid mode,internal structure comparison of advanced metering methods in present scenarios,and communication systems. | Kuldeep Sharma Arun Malik Isha Batra A.S.M.Sanwar Hosen Md Abdul Latif Sarker Dong Seog Han | 2023 | Computers, Materials & Continua2023，，6： | 0 |
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