3篇
您的检索式：作者名="Sheeba John"
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| 1 | Utrasensitive fluorecence-quenched chemosensor for Hg(II) in aqueous solution based on mercaptothiadiazole capped silver nano- particles 显示文摘 | Vasimalai N Sheeba G Abraham John S | 2012 | Journal of Hazadous Materials2012，，： | 1 |
| 2 | Primary carbohydrate metabolism genes participate in heat-stress memory at the shoot apical meristem of Arabidopsis thaliana显示文摘In plants, the shoot apical meristem (SAM) is essential for the growth of aboveground organs. However, little is known about its molecular responses to abiotic stresses. Here, we show that the SAM of Arabidopsis thaliana displays an autonomous heat-stress (HS) memory of a previous non-lethal HS, allowing the SAM to regain growth after exposure to an otherwise lethal HS several days later. Using RNA sequencing, we identified genes participating in establishing the SAM's HS transcriptional memory, including the stem cell (SC) regulators CLAVATA1 (CLV1) and CLV3, HEAT SHOCK PROTEIN 17.6A (HSP17.6A), and the primary carbohydrate metabolism gene FRUCTOSE-BISPHOSPHATE ALDOLASE 6 (FBA6). We demonstrate that sugar availability is essential for survival of plants at high temperature. HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2A) directly regulates the expression of HSP17.6A and FBA6 by binding to the heat-shock elements in their promoters, indicating that HSFA2 is required for transcriptional activation of SAM memory genes. Collectively, these findings indicate that plants have evolved a sophisticated protection mechanism to maintain SCs and, hence, their capacity to re-initiate shoot growth after stress release. | Justyna Jadwiga Olas Federico Apelt Maria Grazia Annunziata Sheeba John Sarah Isabel Richard Saurabh Gupta Friedrich Kragler Salma Balazadeh Bernd Mueller-Roeber | 2021 | Molecular Plant2021，14，9： | 1 |
| 3 | The role of cystatin A in breast cancer and its functional link with ERa显示文摘Aberrant expression of lysosomal cysteine proteinases(cathepsins)leads to abnormal proteolytic processing of extracellular matrix proteins.This in turn promotes invasion,migration and metastasis of tumor cells(Nomura and Katunuma,2005).Cystatins are natural inhibitors of cathepsins.Therefore,dysregulated expression of cystatins and the consequent alteration in the cathepsin:cystatin ratio are likely to play an important role in malignant progression of tumors.This notion is supported by | Dixcy Jaba Sheeba John Mary Mohan C.Manjegowda Ajay Kumar Sarbajeet Dutta Anil M.Limaye | 2017 | Journal of Genetics and Genomics2017，44，12： | 1 |
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